Dataset: Blood DNA methylation of 1 month-old Assaf ewe lambs (F1) born from dams (F0) supplied methionine during the early life

Methionine supplementation during the suckling period of ewe lambs (F0) may modify DNA methylation in the germline (F0) during this critical window period for the neonate, hence promoting inter-generational transmission of epigenetic marks to the offspring (F1). This factor may alter the expression...

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Detalles Bibliográficos
Autores: Andrés, Sonia, Giráldez, Francisco Javier, Martín, Alba, Dehnavi, Mahsa
Tipo de recurso: conjunto de datos
Fecha de publicación:2025
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/389409
Acceso en línea:http://hdl.handle.net/10261/389409
https://doi.org/10.20350/digitalCSIC/17283
Access Level:acceso embargado
Palabra clave:Nutritional programming
Epigenetics
DNA methylation
Dairy sheep
Milk
Methionine
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
Ensure sustainable consumption and production patterns
epigenetics
dairy sheep
milk
methionine
id ES_f3e09c7ee72c7c59a7f00bb2bb2c1c6f
oai_identifier_str oai:digital.csic.es:10261/389409
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Dataset: Blood DNA methylation of 1 month-old Assaf ewe lambs (F1) born from dams (F0) supplied methionine during the early life
title Dataset: Blood DNA methylation of 1 month-old Assaf ewe lambs (F1) born from dams (F0) supplied methionine during the early life
spellingShingle Dataset: Blood DNA methylation of 1 month-old Assaf ewe lambs (F1) born from dams (F0) supplied methionine during the early life
Andrés, Sonia
Nutritional programming
Epigenetics
DNA methylation
Dairy sheep
Milk
Methionine
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
Ensure sustainable consumption and production patterns
epigenetics
dairy sheep
milk
methionine
Milk
title_short Dataset: Blood DNA methylation of 1 month-old Assaf ewe lambs (F1) born from dams (F0) supplied methionine during the early life
title_full Dataset: Blood DNA methylation of 1 month-old Assaf ewe lambs (F1) born from dams (F0) supplied methionine during the early life
title_fullStr Dataset: Blood DNA methylation of 1 month-old Assaf ewe lambs (F1) born from dams (F0) supplied methionine during the early life
title_full_unstemmed Dataset: Blood DNA methylation of 1 month-old Assaf ewe lambs (F1) born from dams (F0) supplied methionine during the early life
title_sort Dataset: Blood DNA methylation of 1 month-old Assaf ewe lambs (F1) born from dams (F0) supplied methionine during the early life
dc.creator.none.fl_str_mv Andrés, Sonia
Giráldez, Francisco Javier
Martín, Alba
Dehnavi, Mahsa
author Andrés, Sonia
author_facet Andrés, Sonia
Giráldez, Francisco Javier
Martín, Alba
Dehnavi, Mahsa
author_role author
author2 Giráldez, Francisco Javier
Martín, Alba
Dehnavi, Mahsa
author2_role author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia e Innovación (España)
European Commission
Consejo Superior de Investigaciones Científicas (España)
Andrés, Sonia [0000-0001-5255-1582]
Giráldez, Francisco Javier [0000-0002-0680-1541]
Martín González, Alba [0000-0002-2531-5047]
Dehnavi, Mahsa [0000-0003-3972-7293]
sonia.andres@eae.csic.es
Andrés, Sonia
Giráldez, Francisco Javier
Andrés, Sonia
Andrés, Sonia
Giráldez, Francisco Javier
Martín, Alba
Dehnavi, Mahsa
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Nutritional programming
Epigenetics
DNA methylation
Dairy sheep
Milk
Methionine
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
Ensure sustainable consumption and production patterns
epigenetics
dairy sheep
milk
methionine
Milk
topic Nutritional programming
Epigenetics
DNA methylation
Dairy sheep
Milk
Methionine
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
Ensure sustainable consumption and production patterns
epigenetics
dairy sheep
milk
methionine
Milk
description Methionine supplementation during the suckling period of ewe lambs (F0) may modify DNA methylation in the germline (F0) during this critical window period for the neonate, hence promoting inter-generational transmission of epigenetic marks to the offspring (F1). This factor may alter the expression of specific genes and physiological traits throughout life of the offspring (F1). The results of the present study revealed that methionine supplementation during the suckling period of ewe lambs (F0) caused the transmission of epigenetic marks to the offspring (DNA obtained from the blood of 1-month old Assaf ewe lambs, F1), so genes involved in Developmental process and Anatomical structure development were differentially methylated in F1-MET when compared to F1-CTRL ewe lambs. Therefore, although the effects on feed efficiency during adulthood were limited, F1-MET dairy sheep showed a reduced live body weight during the whole life.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/dataset
http://purl.org/coar/resource_type/c_ddb1
format dataset
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/389409
https://doi.org/10.20350/digitalCSIC/17283
url http://hdl.handle.net/10261/389409
https://doi.org/10.20350/digitalCSIC/17283
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-126489OB-I00
info:eu-repo/grantAgreement/MICINN//PRE2019-089288
Dehnavi, Mahsa; Martín, Alba; Mateo, Javier; Giráldez, Francisco Javier; Ceciliani, Fabrizio; Biscarini, Filippo; Cremonesi, Paola; Faré, Fiorenza; Santos, Nuria; López, Secundino; Andrés, Sonia; 2026; Methionine supplementation during early post-natal life of ewe lambs: Developmental programming of the female offspring and effects on the first lactation; https://doi.org/10.1016/j.anifeedsci.2026.116640 . http://hdl.handle.net/10261/419969
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/embargoedAccess
eu_rights_str_mv embargoedAccess
dc.format.none.fl_str_mv fastq
dc.publisher.none.fl_str_mv DIGITAL.CSIC
publisher.none.fl_str_mv DIGITAL.CSIC
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869424418619392000
spelling Dataset: Blood DNA methylation of 1 month-old Assaf ewe lambs (F1) born from dams (F0) supplied methionine during the early lifeAndrés, SoniaGiráldez, Francisco JavierMartín, AlbaDehnavi, MahsaNutritional programmingEpigeneticsDNA methylationDairy sheepMilkMethioninehttp://metadata.un.org/sdg/3Ensure healthy lives and promote well-being for all at all agesEnsure sustainable consumption and production patternsepigeneticsdairy sheepmilkmethionineMilkMethionine supplementation during the suckling period of ewe lambs (F0) may modify DNA methylation in the germline (F0) during this critical window period for the neonate, hence promoting inter-generational transmission of epigenetic marks to the offspring (F1). This factor may alter the expression of specific genes and physiological traits throughout life of the offspring (F1). The results of the present study revealed that methionine supplementation during the suckling period of ewe lambs (F0) caused the transmission of epigenetic marks to the offspring (DNA obtained from the blood of 1-month old Assaf ewe lambs, F1), so genes involved in Developmental process and Anatomical structure development were differentially methylated in F1-MET when compared to F1-CTRL ewe lambs. Therefore, although the effects on feed efficiency during adulthood were limited, F1-MET dairy sheep showed a reduced live body weight during the whole life.This work was funded by Ministerio de Ciencia e Innovación (PID2021-126489OB-I00, MCIN/AEI/10.13039/501100011033, “FEDER, Una manera de hacer Europa”); ACRONYM: NUPROVI Alba Martín gratefully acknowledges receipt of a pre-doctoral grant (PRE2019-089288) from Ministerio de Ciencia e Innovación (MCIN/AEI/10.13039/501100011033, “El FSE invierte en tu futuro”); CSIC is acknowledged for supporting Open Access publication.Relationship between files, if important: S_1018_1.fastq (control group, F1-CTRL) S_1018_2.fastq (control group, F1-CTRL) S_1020_1.fastq (control group, F1-CTRL) S_1020_2.fastq (control group, F1-CTRL) S_1022_1.fastq (control group, F1-CTRL) S_1022_2.fastq (control group, F1-CTRL) S_1025_1.fastq (control group, F1-CTRL) S_1025_2.fastq (control group, F1-CTRL) S_1026_1.fastq (control group, F1-CTRL) S_1026_2.fastq (control group, F1-CTRL) S_1033_1.fastq (methionine group, F1-MET) S_1033_2.fastq (methionine group, F1-MET) S_1038_1.fastq (methionine group, F1-MET) S_1038_2.fastq (methionine group, F1-MET) S_1042_1.fastq (methionine group, F1-MET) S_1042_2.fastq (methionine group, F1-MET) S_1043_1.fastq (methionine group, F1-MET) S_1043_2.fastq (methionine group, F1-MET) S_1045_1.fastq (methionine group, F1-MET) S_1045_2.fastq (methionine group, F1-MET)Peer reviewedDIGITAL.CSICMinisterio de Ciencia e Innovación (España)European CommissionConsejo Superior de Investigaciones Científicas (España)Andrés, Sonia [0000-0001-5255-1582]Giráldez, Francisco Javier [0000-0002-0680-1541]Martín González, Alba [0000-0002-2531-5047]Dehnavi, Mahsa [0000-0003-3972-7293]sonia.andres@eae.csic.esAndrés, SoniaGiráldez, Francisco JavierAndrés, SoniaAndrés, SoniaGiráldez, Francisco JavierMartín, AlbaDehnavi, MahsaConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202520252025info:eu-repo/semantics/datasethttp://purl.org/coar/resource_type/c_ddb1fastqhttp://hdl.handle.net/10261/389409https://doi.org/10.20350/digitalCSIC/17283reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-126489OB-I00info:eu-repo/grantAgreement/MICINN//PRE2019-089288Dehnavi, Mahsa; Martín, Alba; Mateo, Javier; Giráldez, Francisco Javier; Ceciliani, Fabrizio; Biscarini, Filippo; Cremonesi, Paola; Faré, Fiorenza; Santos, Nuria; López, Secundino; Andrés, Sonia; 2026; Methionine supplementation during early post-natal life of ewe lambs: Developmental programming of the female offspring and effects on the first lactation; https://doi.org/10.1016/j.anifeedsci.2026.116640 . http://hdl.handle.net/10261/419969Síinfo:eu-repo/semantics/embargoedAccessoai:digital.csic.es:10261/3894092026-05-22T06:33:51Z
score 15,81155

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