Chemoselective addition of grignard reagents to alkoxycarbonylalkyl-N-imidazolium-N-methyl amides: synthesis of 4-oxo and homologous esters

A method for the synthesis of 4-oxo and homologous esters is achieved by metalation of alkoxycarbonylalkyl-N-imidazolium-N-methyl amides with 1equiv of LDA followed by highly chemoselective addition of 1 equiv of a Grignard reagent.

Detalles Bibliográficos
Autores: Heras Muñoz, María Amor de las, Vaquero López, Juan José|||0000-0002-3820-9673, García Navío, José Luis, Álvarez-Builla Gómez, Julio
Tipo de recurso: artículo
Fecha de publicación:1997
País:España
Institución:Universidad de Alcalá (UAH)
Repositorio:e_Buah Biblioteca Digital Universidad de Alcalá
Idioma:inglés
OAI Identifier:oai:ebuah.uah.es:10017/2707
Acceso en línea:http://hdl.handle.net/10017/2707
https://dx.doi.org/10.1016/S0040-4039(97)00159-7
Access Level:acceso abierto
Palabra clave:Addition reaction
Grignard reagents role: RCT
Amides role
Chemoselective addn
Carboxylic acids role
Chemoselective
ADDN
Grignard
Imidazoliomethyl
Amide
Oxo
Ester
Bioquímica
Ciencia
Biochemistry
Science
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spelling Chemoselective addition of grignard reagents to alkoxycarbonylalkyl-N-imidazolium-N-methyl amides: synthesis of 4-oxo and homologous estersHeras Muñoz, María Amor de lasVaquero López, Juan José|||0000-0002-3820-9673García Navío, José LuisÁlvarez-Builla Gómez, JulioAddition reactionGrignard reagents role: RCTAmides roleChemoselective addnCarboxylic acids roleChemoselectiveADDNGrignardImidazoliomethylAmideOxoEsterBioquímicaCienciaBiochemistryScienceA method for the synthesis of 4-oxo and homologous esters is achieved by metalation of alkoxycarbonylalkyl-N-imidazolium-N-methyl amides with 1equiv of LDA followed by highly chemoselective addition of 1 equiv of a Grignard reagent.Ministerio de Educación y CienciaComisió Interdepartamental de Recerça i Innovació TécnologicaPergamon19971997-01-01journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10017/2707https://dx.doi.org/10.1016/S0040-4039(97)00159-7reponame:e_Buah Biblioteca Digital Universidad de Alcaláinstname:Universidad de Alcalá (UAH)InglésengCIRIT Not available QFN94-4619open accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ebuah.uah.es:10017/27072026-06-18T11:13:07Z
dc.title.none.fl_str_mv Chemoselective addition of grignard reagents to alkoxycarbonylalkyl-N-imidazolium-N-methyl amides: synthesis of 4-oxo and homologous esters
title Chemoselective addition of grignard reagents to alkoxycarbonylalkyl-N-imidazolium-N-methyl amides: synthesis of 4-oxo and homologous esters
spellingShingle Chemoselective addition of grignard reagents to alkoxycarbonylalkyl-N-imidazolium-N-methyl amides: synthesis of 4-oxo and homologous esters
Heras Muñoz, María Amor de las
Addition reaction
Grignard reagents role: RCT
Amides role
Chemoselective addn
Carboxylic acids role
Chemoselective
ADDN
Grignard
Imidazoliomethyl
Amide
Oxo
Ester
Bioquímica
Ciencia
Biochemistry
Science
title_short Chemoselective addition of grignard reagents to alkoxycarbonylalkyl-N-imidazolium-N-methyl amides: synthesis of 4-oxo and homologous esters
title_full Chemoselective addition of grignard reagents to alkoxycarbonylalkyl-N-imidazolium-N-methyl amides: synthesis of 4-oxo and homologous esters
title_fullStr Chemoselective addition of grignard reagents to alkoxycarbonylalkyl-N-imidazolium-N-methyl amides: synthesis of 4-oxo and homologous esters
title_full_unstemmed Chemoselective addition of grignard reagents to alkoxycarbonylalkyl-N-imidazolium-N-methyl amides: synthesis of 4-oxo and homologous esters
title_sort Chemoselective addition of grignard reagents to alkoxycarbonylalkyl-N-imidazolium-N-methyl amides: synthesis of 4-oxo and homologous esters
dc.creator.none.fl_str_mv Heras Muñoz, María Amor de las
Vaquero López, Juan José|||0000-0002-3820-9673
García Navío, José Luis
Álvarez-Builla Gómez, Julio
author Heras Muñoz, María Amor de las
author_facet Heras Muñoz, María Amor de las
Vaquero López, Juan José|||0000-0002-3820-9673
García Navío, José Luis
Álvarez-Builla Gómez, Julio
author_role author
author2 Vaquero López, Juan José|||0000-0002-3820-9673
García Navío, José Luis
Álvarez-Builla Gómez, Julio
author2_role author
author
author
dc.subject.none.fl_str_mv Addition reaction
Grignard reagents role: RCT
Amides role
Chemoselective addn
Carboxylic acids role
Chemoselective
ADDN
Grignard
Imidazoliomethyl
Amide
Oxo
Ester
Bioquímica
Ciencia
Biochemistry
Science
topic Addition reaction
Grignard reagents role: RCT
Amides role
Chemoselective addn
Carboxylic acids role
Chemoselective
ADDN
Grignard
Imidazoliomethyl
Amide
Oxo
Ester
Bioquímica
Ciencia
Biochemistry
Science
description A method for the synthesis of 4-oxo and homologous esters is achieved by metalation of alkoxycarbonylalkyl-N-imidazolium-N-methyl amides with 1equiv of LDA followed by highly chemoselective addition of 1 equiv of a Grignard reagent.
publishDate 1997
dc.date.none.fl_str_mv 1997
1997-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10017/2707
https://dx.doi.org/10.1016/S0040-4039(97)00159-7
url http://hdl.handle.net/10017/2707
https://dx.doi.org/10.1016/S0040-4039(97)00159-7
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv CIRIT Not available QFN94-4619
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Pergamon
publisher.none.fl_str_mv Pergamon
dc.source.none.fl_str_mv reponame:e_Buah Biblioteca Digital Universidad de Alcalá
instname:Universidad de Alcalá (UAH)
instname_str Universidad de Alcalá (UAH)
reponame_str e_Buah Biblioteca Digital Universidad de Alcalá
collection e_Buah Biblioteca Digital Universidad de Alcalá
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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