Copper-catalysed cross-coupling of alkyl Grignard reagents and propargylic ammonium salts: Stereospecific synthesis of allenes
Herein we describe a robust and practical method to prepare enantiomerically enriched trisubstituted allenes using alkyl Grignard reagents and bench stable propargylic ammonium salts. Excellent yields as well as regio- and stereoselectivities are observed. Our conditions provide a solution to the al...
| Autores: | , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2018 |
| País: | España |
| Institución: | Universidad Autónoma de Madrid |
| Repositorio: | Biblos-e Archivo. Repositorio Institucional de la UAM |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.uam.es:10486/685378 |
| Acceso en línea: | http://hdl.handle.net/10486/685378 https://dx.doi.org/10.1039/c8cc03760d |
| Access Level: | acceso abierto |
| Palabra clave: | Grignard reagents Ammonium salts Racemization Allenes Copper-catalysed Química |
| Sumario: | Herein we describe a robust and practical method to prepare enantiomerically enriched trisubstituted allenes using alkyl Grignard reagents and bench stable propargylic ammonium salts. Excellent yields as well as regio- and stereoselectivities are observed. Our conditions provide a solution to the allene racemization, which has been a long-standing problem when using Grignard reagents |
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