Chemoselective addition of grignard reagents to alkoxycarbonylalkyl-N-imidazolium-N-methyl amides: synthesis of 4-oxo and homologous esters
A method for the synthesis of 4-oxo and homologous esters is achieved by metalation of alkoxycarbonylalkyl-N-imidazolium-N-methyl amides with 1equiv of LDA followed by highly chemoselective addition of 1 equiv of a Grignard reagent.
| Autores: | , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 1997 |
| País: | España |
| Institución: | Universidad de Alcalá (UAH) |
| Repositorio: | e_Buah Biblioteca Digital Universidad de Alcalá |
| Idioma: | inglés |
| OAI Identifier: | oai:ebuah.uah.es:10017/2707 |
| Acceso en línea: | http://hdl.handle.net/10017/2707 https://dx.doi.org/10.1016/S0040-4039(97)00159-7 |
| Access Level: | acceso abierto |
| Palabra clave: | Addition reaction Grignard reagents role: RCT Amides role Chemoselective addn Carboxylic acids role Chemoselective ADDN Grignard Imidazoliomethyl Amide Oxo Ester Bioquímica Ciencia Biochemistry Science |
| Sumario: | A method for the synthesis of 4-oxo and homologous esters is achieved by metalation of alkoxycarbonylalkyl-N-imidazolium-N-methyl amides with 1equiv of LDA followed by highly chemoselective addition of 1 equiv of a Grignard reagent. |
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