Peroxygenase-Catalysed Selective Oxidation of Silanes to Silanols

A peroxygenase-catalysed hydroxylation of organosilanes is reported. The recombinant peroxygenase from Agrocybe aegerita (AaeUPO) enabled efficient conversion of a broad range of silane starting materials in attractive productivities (up to 300 mM h−1), catalyst performance (up to 84 s−1 and more th...

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Detalles Bibliográficos
Autores: Xu, X., van Hengst, J.M.A., Mao, Y., Prieto-Martínez, M. Pilar, Roda, S., Floor, M., Guallar, Víctor, Paul, Caroline E., Alcalde Galeote, Miguel, Hollmann, F.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/357430
Acceso en línea:http://hdl.handle.net/10261/357430
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85156129295&doi=10.1002%2fanie.202302844&partnerID=40&md5=c60ef0e102d4c165e20eeb95034ca187
Access Level:acceso abierto
Palabra clave:Biocatalysis
Oxyfunctionalization
PELE Simulations
Peroxygenase
Silanols
Descripción
Sumario:A peroxygenase-catalysed hydroxylation of organosilanes is reported. The recombinant peroxygenase from Agrocybe aegerita (AaeUPO) enabled efficient conversion of a broad range of silane starting materials in attractive productivities (up to 300 mM h−1), catalyst performance (up to 84 s−1 and more than 120 000 catalytic turnovers). Molecular modelling of the enzyme-substrate interaction puts a basis for the mechanistic understanding of AaeUPO selectivity. © 2023 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.

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