Selective Peroxygenase-Catalysed Oxidation of Toluene Derivates to Benzaldehydes
Biocatalytic oxidation reactions of toluene derivates to the corresponding aldehydes are typically challenged by regio- and chemoselectivity issues. In this contribution we address both challenges by a combined reactant- and reaction engineering approach. We demonstrate that the peroxygenase-catalys...
| Autores: | , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/359632 |
| Acceso en línea: | http://hdl.handle.net/10261/359632 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85162015029&doi=10.1002%2fcctc.202300645&partnerID=40&md5=279cf58a5fd578e9379dd48a044145b9 |
| Access Level: | acceso abierto |
| Palabra clave: | Benzaldehydes Biocatalytic oxidation Peroxygenase Selective oxyfunctionalisation Solvent-free biocatalysis |
| Sumario: | Biocatalytic oxidation reactions of toluene derivates to the corresponding aldehydes are typically challenged by regio- and chemoselectivity issues. In this contribution we address both challenges by a combined reactant- and reaction engineering approach. We demonstrate that the peroxygenase-catalysed transformation of ring-substituted toluenes proceeds highly regioselectively in benzylic position. Furthermore, neat reaction conditions not only enable attractive product concentrations (up to 185 mM) but also result in highly chemoselective oxidations to the aldehyde level. © 2023 The Authors. ChemCatChem published by Wiley-VCH GmbH. |
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