Differences in the peripheral blood immune landscape between early-onset and late-onset colorectal cancer

This study aims to discover novel immune biomarkers specific to EOCRC that may permit the development of a non-invasive, peripheral blood-based “liquid Immunoscore” that may integrate specific quantitative measurements. By contrasting the immune landscapes of EOCRC and LOCRC based on key immune cell...

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Bibliographic Details
Authors: Sánchez-Menéndez, Clara, Rodríguez-Pérez, Jaime, Fuertes, Daniel, Leguizamon, Valentina, González-Sanmartin, María, Mateos, Elena, Cervero, Miguel, San José Martínez, Esther, Sanz, Gonzalo, Álvaro, Edurne, Et. al.
Format: article
Publication Date:2025
Country:España
Institution:Universidad Europea (UEM)
Repository:ABACUS. Repositorio de Producción Científica
Language:English
OAI Identifier:oai:abacus.universidadeuropea.com:11268/16617
Online Access:https://hdl.handle.net/11268/16617
Access Level:Open access
Keyword:Neoplasias colorrectales
Diagnóstico precoz
Inmunidad
Cáncer
Medicina preventiva
Investigación médica
Goal 3: Ensure healthy lives and promote well-being for all at all ages
Description
Summary:This study aims to discover novel immune biomarkers specific to EOCRC that may permit the development of a non-invasive, peripheral blood-based “liquid Immunoscore” that may integrate specific quantitative measurements. By contrasting the immune landscapes of EOCRC and LOCRC based on key immune cell subsets, exhaustion markers, soluble cytokines, and metabolic capacity, we seek to improve early detection, enable more timely and personalized treatment, and ultimately identify individuals under 50 at high risk for EOCRC before tumors become clinically detectable.

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