Severity of respiratory syncytial virus compared with SARS-CoV-2 and influenza among hospitalised adults ≥65 years.

Vega-Piris, Lorena; Galindo Carretero, Silvia; Mayordomo, José Luis; Rumayor-Zarzuelo, Mercedes Belén; Álvarez Río, Virginia; Gallardo García, Virtudes; García Vázquez, Miriam; García Rodríguez, María Del Carmen; Basile, Luca; López González-Coviella, Nieves; Barranco Boada, Maria Isabel; Pérez-Martínez, Olaia; Lameiras Azevedo, Ana; Quiñones-Rubio, Carmen; Giménez Duran, Jaume; Fernández Ibáñez, Ana; García Rivera, María Victoria; Ramos Marín, Violeta; Castrillejo, Daniel; Voloria Raymundo, Luis Javier; Larrauri, Amparo; Monge Corella, Susana; SARI Sentinel Surveillance Group

Severity of respiratory syncytial virus compared with SARS-CoV-2 and influenza among hospitalised adults ≥65 years.

Introduction: Our aim was to estimate the risk of pneumonia, admission to intensive care unit (ICU) or death in individuals ≥65 years old admitted to hospital with RSV, compared to influenza or COVID-19. Methods: We included hospitalised patients from Severe Acute Respiratory Infection Surveillance...

Descripción completa

Detalles Bibliográficos
Autores:	Vega-Piris, Lorena, Galindo Carretero, Silvia, Mayordomo, José Luis, Rumayor-Zarzuelo, Mercedes Belén, Álvarez Río, Virginia, Gallardo García, Virtudes, García Vázquez, Miriam, García Rodríguez, María Del Carmen, Basile, Luca, López González-Coviella, Nieves, Barranco Boada, Maria Isabel, Pérez-Martínez, Olaia, Lameiras Azevedo, Ana, Quiñones-Rubio, Carmen, Giménez Duran, Jaume, Fernández Ibáñez, Ana, García Rivera, María Victoria, Ramos Marín, Violeta, Castrillejo, Daniel, Voloria Raymundo, Luis Javier, Larrauri, Amparo, Monge Corella, Susana, SARI Sentinel Surveillance Group
Tipo de recurso:	artículo
Fecha de publicación:	2024
País:	España
Institución:	Instituto de Salud Carlos III (ISCIII)
Repositorio:	Repisalud
Idioma:	inglés
OAI Identifier:	oai:repisalud.isciii.es:20.500.12105/25460
Acceso en línea:	https://hdl.handle.net/20.500.12105/25460
Access Level:	acceso abierto
Palabra clave:	ICU admission Influenza Mortality Pneumonia SARS-CoV2 Severe acute respiratory infection Syncytial respiratory virus Vaccination Aged Aged, 80 and over COVID-19 Female Hospital Mortality Hospitalization Humans Influenza, Human Intensive Care Units Male Respiratory Syncytial Virus Infections Respiratory Syncytial Virus, Human SARS-CoV-2 Severity of Illness Index Spain

id	ES_ed90fdf8731a2cf49fadf960aed44248
oai_identifier_str	oai:repisalud.isciii.es:20.500.12105/25460
network_acronym_str	ES
network_name_str	España
repository_id_str
spelling	Severity of respiratory syncytial virus compared with SARS-CoV-2 and influenza among hospitalised adults ≥65 years.Vega-Piris, LorenaGalindo Carretero, SilviaMayordomo, José LuisRumayor-Zarzuelo, Mercedes BelénÁlvarez Río, VirginiaGallardo García, VirtudesGarcía Vázquez, MiriamGarcía Rodríguez, María Del CarmenBasile, LucaLópez González-Coviella, NievesBarranco Boada, Maria IsabelPérez-Martínez, OlaiaLameiras Azevedo, AnaQuiñones-Rubio, CarmenGiménez Duran, JaumeFernández Ibáñez, AnaGarcía Rivera, María VictoriaRamos Marín, VioletaCastrillejo, DanielVoloria Raymundo, Luis JavierLarrauri, AmparoMonge Corella, SusanaSARI Sentinel Surveillance GroupICU admissionInfluenzaMortalityPneumoniaSARS-CoV2Severe acute respiratory infectionSyncytial respiratory virusVaccinationAgedAged, 80 and overCOVID-19FemaleHospital MortalityHospitalizationHumansInfluenza, HumanIntensive Care UnitsMaleRespiratory Syncytial Virus InfectionsRespiratory Syncytial Virus, HumanSARS-CoV-2Severity of Illness IndexSpainIntroduction: Our aim was to estimate the risk of pneumonia, admission to intensive care unit (ICU) or death in individuals ≥65 years old admitted to hospital with RSV, compared to influenza or COVID-19. Methods: We included hospitalised patients from Severe Acute Respiratory Infection Surveillance in Spain between 2021-2024, aged ≥65 years, laboratory confirmed for RSV, influenza or SARS-CoV-2. Using a binomial regression with logarithmic link, we estimated the relative risk (RR) of pneumonia, ICU admission and in-hospital mortality, in patients with RSV compared to influenza or SARS-CoV-2, adjusting for age, sex, season and comorbidities. We stratified the estimates by vaccination status for influenza or SARS-CoV2. Results: Among patients unvaccinated for influenza or SARS-CoV-2, those with RSV had similar or lower risk of pneumonia [vs. influenza: RR= 0.91 (95% Confidence Interval: 0.72-1.16); vs. SARS-CoV-2: 0.81 (0.67-0.98)], ICU admission [vs. influenza: 0.93 (0.41-2.08); vs. SARS-CoV-2: 1.10 (0.61-1.99)] and mortality [vs. influenza: 0.64 (0.32-1.28); vs. SARS-CoV-2: 0.56 (0.30-1.04)]. Among the vaccinated, results were largely similar except for a higher risk of ICU admission with RSV [vs. influenza: 2.13(1.16-3.89); vs. SARS-CoV-2: 1.83 (1.02-3.28)] CONCLUSIONS: RSV presented similar or lower intrinsic severity than influenza or SARS-CoV2. Among vaccinated patients, RSV was associated to higher ICU-admission, suggesting the potential for preventive RSV vaccination.Elsevier20242024-11-0820242024-11-0120242024-11-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfapplication/pdfapplication/pdfhttps://hdl.handle.net/20.500.12105/25460reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/254602026-06-12T12:43:37Z
dc.title.none.fl_str_mv	Severity of respiratory syncytial virus compared with SARS-CoV-2 and influenza among hospitalised adults ≥65 years.
title	Severity of respiratory syncytial virus compared with SARS-CoV-2 and influenza among hospitalised adults ≥65 years.
spellingShingle	Severity of respiratory syncytial virus compared with SARS-CoV-2 and influenza among hospitalised adults ≥65 years. Vega-Piris, Lorena ICU admission Influenza Mortality Pneumonia SARS-CoV2 Severe acute respiratory infection Syncytial respiratory virus Vaccination Aged Aged, 80 and over COVID-19 Female Hospital Mortality Hospitalization Humans Influenza, Human Intensive Care Units Male Respiratory Syncytial Virus Infections Respiratory Syncytial Virus, Human SARS-CoV-2 Severity of Illness Index Spain
title_short	Severity of respiratory syncytial virus compared with SARS-CoV-2 and influenza among hospitalised adults ≥65 years.
title_full	Severity of respiratory syncytial virus compared with SARS-CoV-2 and influenza among hospitalised adults ≥65 years.
title_fullStr	Severity of respiratory syncytial virus compared with SARS-CoV-2 and influenza among hospitalised adults ≥65 years.
title_full_unstemmed	Severity of respiratory syncytial virus compared with SARS-CoV-2 and influenza among hospitalised adults ≥65 years.
title_sort	Severity of respiratory syncytial virus compared with SARS-CoV-2 and influenza among hospitalised adults ≥65 years.
dc.creator.none.fl_str_mv	Vega-Piris, Lorena Galindo Carretero, Silvia Mayordomo, José Luis Rumayor-Zarzuelo, Mercedes Belén Álvarez Río, Virginia Gallardo García, Virtudes García Vázquez, Miriam García Rodríguez, María Del Carmen Basile, Luca López González-Coviella, Nieves Barranco Boada, Maria Isabel Pérez-Martínez, Olaia Lameiras Azevedo, Ana Quiñones-Rubio, Carmen Giménez Duran, Jaume Fernández Ibáñez, Ana García Rivera, María Victoria Ramos Marín, Violeta Castrillejo, Daniel Voloria Raymundo, Luis Javier Larrauri, Amparo Monge Corella, Susana SARI Sentinel Surveillance Group
author	Vega-Piris, Lorena
author_facet	Vega-Piris, Lorena Galindo Carretero, Silvia Mayordomo, José Luis Rumayor-Zarzuelo, Mercedes Belén Álvarez Río, Virginia Gallardo García, Virtudes García Vázquez, Miriam García Rodríguez, María Del Carmen Basile, Luca López González-Coviella, Nieves Barranco Boada, Maria Isabel Pérez-Martínez, Olaia Lameiras Azevedo, Ana Quiñones-Rubio, Carmen Giménez Duran, Jaume Fernández Ibáñez, Ana García Rivera, María Victoria Ramos Marín, Violeta Castrillejo, Daniel Voloria Raymundo, Luis Javier Larrauri, Amparo Monge Corella, Susana SARI Sentinel Surveillance Group
author_role	author
author2	Galindo Carretero, Silvia Mayordomo, José Luis Rumayor-Zarzuelo, Mercedes Belén Álvarez Río, Virginia Gallardo García, Virtudes García Vázquez, Miriam García Rodríguez, María Del Carmen Basile, Luca López González-Coviella, Nieves Barranco Boada, Maria Isabel Pérez-Martínez, Olaia Lameiras Azevedo, Ana Quiñones-Rubio, Carmen Giménez Duran, Jaume Fernández Ibáñez, Ana García Rivera, María Victoria Ramos Marín, Violeta Castrillejo, Daniel Voloria Raymundo, Luis Javier Larrauri, Amparo Monge Corella, Susana SARI Sentinel Surveillance Group
author2_role	author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv	ICU admission Influenza Mortality Pneumonia SARS-CoV2 Severe acute respiratory infection Syncytial respiratory virus Vaccination Aged Aged, 80 and over COVID-19 Female Hospital Mortality Hospitalization Humans Influenza, Human Intensive Care Units Male Respiratory Syncytial Virus Infections Respiratory Syncytial Virus, Human SARS-CoV-2 Severity of Illness Index Spain
topic	ICU admission Influenza Mortality Pneumonia SARS-CoV2 Severe acute respiratory infection Syncytial respiratory virus Vaccination Aged Aged, 80 and over COVID-19 Female Hospital Mortality Hospitalization Humans Influenza, Human Intensive Care Units Male Respiratory Syncytial Virus Infections Respiratory Syncytial Virus, Human SARS-CoV-2 Severity of Illness Index Spain
description	Introduction: Our aim was to estimate the risk of pneumonia, admission to intensive care unit (ICU) or death in individuals ≥65 years old admitted to hospital with RSV, compared to influenza or COVID-19. Methods: We included hospitalised patients from Severe Acute Respiratory Infection Surveillance in Spain between 2021-2024, aged ≥65 years, laboratory confirmed for RSV, influenza or SARS-CoV-2. Using a binomial regression with logarithmic link, we estimated the relative risk (RR) of pneumonia, ICU admission and in-hospital mortality, in patients with RSV compared to influenza or SARS-CoV-2, adjusting for age, sex, season and comorbidities. We stratified the estimates by vaccination status for influenza or SARS-CoV2. Results: Among patients unvaccinated for influenza or SARS-CoV-2, those with RSV had similar or lower risk of pneumonia [vs. influenza: RR= 0.91 (95% Confidence Interval: 0.72-1.16); vs. SARS-CoV-2: 0.81 (0.67-0.98)], ICU admission [vs. influenza: 0.93 (0.41-2.08); vs. SARS-CoV-2: 1.10 (0.61-1.99)] and mortality [vs. influenza: 0.64 (0.32-1.28); vs. SARS-CoV-2: 0.56 (0.30-1.04)]. Among the vaccinated, results were largely similar except for a higher risk of ICU admission with RSV [vs. influenza: 2.13(1.16-3.89); vs. SARS-CoV-2: 1.83 (1.02-3.28)] CONCLUSIONS: RSV presented similar or lower intrinsic severity than influenza or SARS-CoV2. Among vaccinated patients, RSV was associated to higher ICU-admission, suggesting the potential for preventive RSV vaccination.
publishDate	2024
dc.date.none.fl_str_mv	2024 2024-11-08 2024 2024-11-01 2024 2024-11-01
dc.type.none.fl_str_mv	research article http://purl.org/coar/resource_type/c_2df8fbb1 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://hdl.handle.net/20.500.12105/25460
url	https://hdl.handle.net/20.500.12105/25460
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf application/pdf application/pdf
dc.publisher.none.fl_str_mv	Elsevier
publisher.none.fl_str_mv	Elsevier
dc.source.none.fl_str_mv	reponame:Repisalud instname:Instituto de Salud Carlos III (ISCIII)
instname_str	Instituto de Salud Carlos III (ISCIII)
reponame_str	Repisalud
collection	Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_	1869423515620343808
score	15.811543

Severity of respiratory syncytial virus compared with SARS-CoV-2 and influenza among hospitalised adults ≥65 years.

Similares en LA Referencia