Severity of respiratory syncytial virus compared with SARS-CoV-2 and influenza among hospitalised adults ≥65 years.

Introduction: Our aim was to estimate the risk of pneumonia, admission to intensive care unit (ICU) or death in individuals ≥65 years old admitted to hospital with RSV, compared to influenza or COVID-19. Methods: We included hospitalised patients from Severe Acute Respiratory Infection Surveillance...

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Detalles Bibliográficos
Autores: Vega-Piris, Lorena, Galindo Carretero, Silvia, Mayordomo, José Luis, Rumayor-Zarzuelo, Mercedes Belén, Álvarez Río, Virginia, Gallardo García, Virtudes, García Vázquez, Miriam, García Rodríguez, María Del Carmen, Basile, Luca, López González-Coviella, Nieves, Barranco Boada, Maria Isabel, Pérez-Martínez, Olaia, Lameiras Azevedo, Ana, Quiñones-Rubio, Carmen, Giménez Duran, Jaume, Fernández Ibáñez, Ana, García Rivera, María Victoria, Ramos Marín, Violeta, Castrillejo, Daniel, Voloria Raymundo, Luis Javier, Larrauri, Amparo, Monge Corella, Susana, SARI Sentinel Surveillance Group
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/25460
Acceso en línea:https://hdl.handle.net/20.500.12105/25460
Access Level:acceso abierto
Palabra clave:ICU admission
Influenza
Mortality
Pneumonia
SARS-CoV2
Severe acute respiratory infection
Syncytial respiratory virus
Vaccination
Aged
Aged, 80 and over
COVID-19
Female
Hospital Mortality
Hospitalization
Humans
Influenza, Human
Intensive Care Units
Male
Respiratory Syncytial Virus Infections
Respiratory Syncytial Virus, Human
SARS-CoV-2
Severity of Illness Index
Spain
Descripción
Sumario:Introduction: Our aim was to estimate the risk of pneumonia, admission to intensive care unit (ICU) or death in individuals ≥65 years old admitted to hospital with RSV, compared to influenza or COVID-19. Methods: We included hospitalised patients from Severe Acute Respiratory Infection Surveillance in Spain between 2021-2024, aged ≥65 years, laboratory confirmed for RSV, influenza or SARS-CoV-2. Using a binomial regression with logarithmic link, we estimated the relative risk (RR) of pneumonia, ICU admission and in-hospital mortality, in patients with RSV compared to influenza or SARS-CoV-2, adjusting for age, sex, season and comorbidities. We stratified the estimates by vaccination status for influenza or SARS-CoV2. Results: Among patients unvaccinated for influenza or SARS-CoV-2, those with RSV had similar or lower risk of pneumonia [vs. influenza: RR= 0.91 (95% Confidence Interval: 0.72-1.16); vs. SARS-CoV-2: 0.81 (0.67-0.98)], ICU admission [vs. influenza: 0.93 (0.41-2.08); vs. SARS-CoV-2: 1.10 (0.61-1.99)] and mortality [vs. influenza: 0.64 (0.32-1.28); vs. SARS-CoV-2: 0.56 (0.30-1.04)]. Among the vaccinated, results were largely similar except for a higher risk of ICU admission with RSV [vs. influenza: 2.13(1.16-3.89); vs. SARS-CoV-2: 1.83 (1.02-3.28)] CONCLUSIONS: RSV presented similar or lower intrinsic severity than influenza or SARS-CoV2. Among vaccinated patients, RSV was associated to higher ICU-admission, suggesting the potential for preventive RSV vaccination.

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