Severity of respiratory syncytial virus compared with SARS-CoV-2 and influenza among hospitalised adults ≥65 years

Our aim was to estimate the risk of pneumonia, admission to intensive care unit (ICU) or death in individuals ≥65 years old admitted to hospital with RSV, compared to influenza or COVID-19. We included hospitalised patients from Severe Acute Respiratory Infection Surveillance in Spain between 2021-2...

Descripción completa

Detalles Bibliográficos
Autores: Vega-Piris, Lorena., Galindo Carretero, Silvia, Mayordomo, José Luis, Rumayor Zarzuelo, Mercedes Belén, Álvarez Río, Virginia, Gallardo García, Virtudes, García vázquez, Miriam, García Rodríguez, María del Carmen, Basile, Luca, López González-Coviella, Nieves, Barranco Boada, María Isabel, Pérez-Martínez, Olaia, Lameiras Azevedo, Ana, Quiñones Rubio, Carmen, Gimenez Duran, Jaume, Fernández Ibáñez, Ana, García Rivera, María Victoria, Ramos Marín, Violeta, Castrillejo, Daniel, Viloria Raymundo, Luis Javier, Larrauri, Amparo, Monge, Susana
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Conselleria de Salut i Consum del Govern de les Illes Balears
Repositorio:Docusalut
Idioma:inglés
OAI Identifier:oai:docusalut.com:20.500.13003/21142
Acceso en línea:https://hdl.handle.net/20.500.13003/21142
Access Level:acceso abierto
Palabra clave:Aged, 80 and over
Aged
SARS-CoV-2
Spain
Hospital Mortality
Humans
Hospitalization
Intensive Care Units
Male
Severity of Illness Index
Influenza, Human
Female
COVID-19
Respiratory Syncytial Virus, Human
Respiratory Syncytial Virus Infections
Infecciones por Virus Sincitial Respiratorio
Femenino
Hospitalización
Gripe Humana
Unidades de Cuidados Intensivos
Masculino
Humanos
Anciano
Mortalidad Hospitalaria
Índice de Severidad de la Enfermedad
Anciano de 80 o más Años
Virus Sincitial Respiratorio Humano
España
Descripción
Sumario:Our aim was to estimate the risk of pneumonia, admission to intensive care unit (ICU) or death in individuals ≥65 years old admitted to hospital with RSV, compared to influenza or COVID-19. We included hospitalised patients from Severe Acute Respiratory Infection Surveillance in Spain between 2021-2024, aged ≥65 years, laboratory confirmed for RSV, influenza or SARS-CoV-2. Using a binomial regression with logarithmic link, we estimated the relative risk (RR) of pneumonia, ICU admission and in-hospital mortality, in patients with RSV compared to influenza or SARS-CoV-2, adjusting for age, sex, season and comorbidities. We stratified the estimates by vaccination status for influenza or SARS-CoV2. Among patients unvaccinated for influenza or SARS-CoV-2, those with RSV had similar or lower risk of pneumonia [vs. influenza: RR= 0.91 (95% Confidence Interval: 0.72-1.16); vs. SARS-CoV-2: 0.81 (0.67-0.98)], ICU admission [vs. influenza: 0.93 (0.41-2.08); vs. SARS-CoV-2: 1.10 (0.61-1.99)] and mortality [vs. influenza: 0.64 (0.32-1.28); vs. SARS-CoV-2: 0.56 (0.30-1.04)]. Among the vaccinated, results were largely similar except for a higher risk of ICU admission with RSV [vs. influenza: 2.13(1.16-3.89); vs. SARS-CoV-2: 1.83 (1.02-3.28)] CONCLUSIONS: RSV presented similar or lower intrinsic severity than influenza or SARS-CoV2. Among vaccinated patients, RSV was associated to higher ICU-admission, suggesting the potential for preventive RSV vaccination.

Similares en LA Referencia