Spatial distribution of calcium sparks determines their ability to induce afterdepolarizations in human atrial myocytes

Tarifa Lora, Carmen; Vallmitjana Lees, Alexander; Jiménez Sábado, Verónica; Marchena Angos, Miquel; Llach, Anna; Herraiz Martínez, Adela; Nolla Colomer, Carme; Ginel Iglesias, Antonino; Montiel Dacosta, José Antonio; Ciruela, Francisco; Echebarría Domínguez, Blas|||0000-0003-0503-1781; Benítez Iglesias, Raúl|||0000-0002-8782-9406; Cinca Cuscullola, Juan Maria; Hove-Madsen, Leif|||0000-0001-5493-3998

Spatial distribution of calcium sparks determines their ability to induce afterdepolarizations in human atrial myocytes

Analysis of the spatio-temporal distribution of calcium sparks showed a preferential increase in sparks near the sarcolemma in atrial myocytes from patients with atrial fibrillation (AF), linked to higher ryanodine receptor (RyR2) phosphorylation at s2808 and lower calsequestrin-2 levels. Mathematic...

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Autores:	Tarifa Lora, Carmen, Vallmitjana Lees, Alexander, Jiménez Sábado, Verónica, Marchena Angos, Miquel, Llach, Anna, Herraiz Martínez, Adela, Nolla Colomer, Carme, Ginel Iglesias, Antonino, Montiel Dacosta, José Antonio, Ciruela, Francisco, Echebarría Domínguez, Blas\|\|\|0000-0003-0503-1781, Benítez Iglesias, Raúl\|\|\|0000-0002-8782-9406, Cinca Cuscullola, Juan Maria, Hove-Madsen, Leif\|\|\|0000-0001-5493-3998
Tipo de recurso:	artículo
Fecha de publicación:	2023
País:	España
Institución:	Universitat Politècnica de Catalunya (UPC)
Repositorio:	UPCommons. Portal del coneixement obert de la UPC
Idioma:	inglés
OAI Identifier:	oai:upcommons.upc.edu:2117/401668
Acceso en línea:	https://hdl.handle.net/2117/401668 https://dx.doi.org/10.1016/j.jacbts.2022.07.013
Access Level:	acceso abierto
Palabra clave:	Atrial fibrillation Ryanodine--Receptors Human atrial myocyte Ryanodine receptor Sarcoplasmic reticulum Transient inward currents Fibril·lació auricular Rianodina--Receptors Àrees temàtiques de la UPC::Física

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spelling	Spatial distribution of calcium sparks determines their ability to induce afterdepolarizations in human atrial myocytesTarifa Lora, CarmenVallmitjana Lees, AlexanderJiménez Sábado, VerónicaMarchena Angos, MiquelLlach, AnnaHerraiz Martínez, AdelaNolla Colomer, CarmeGinel Iglesias, AntoninoMontiel Dacosta, José AntonioCiruela, FranciscoEchebarría Domínguez, Blas\|\|\|0000-0003-0503-1781Benítez Iglesias, Raúl\|\|\|0000-0002-8782-9406Cinca Cuscullola, Juan MariaHove-Madsen, Leif\|\|\|0000-0001-5493-3998Atrial fibrillationRyanodine--ReceptorsAtrial fibrillationHuman atrial myocyteRyanodine receptorSarcoplasmic reticulumTransient inward currentsFibril·lació auricularRianodina--ReceptorsÀrees temàtiques de la UPC::FísicaAnalysis of the spatio-temporal distribution of calcium sparks showed a preferential increase in sparks near the sarcolemma in atrial myocytes from patients with atrial fibrillation (AF), linked to higher ryanodine receptor (RyR2) phosphorylation at s2808 and lower calsequestrin-2 levels. Mathematical modeling, incorporating modulation of RyR2 gating, showed that only the observed combinations of RyR2 phosphorylation and calsequestrin-2 levels can account for the spatio-temporal distribution of sparks in patients with and without AF. Furthermore, we demonstrate that preferential calcium release near the sarcolemma is key to a higher incidence and amplitude of afterdepolarizations in atrial myocytes from patients with AF.Elsevier20232023-01-0120242024-02-09journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/401668https://dx.doi.org/10.1016/j.jacbts.2022.07.013reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/4016682026-05-27T15:37:01Z
dc.title.none.fl_str_mv	Spatial distribution of calcium sparks determines their ability to induce afterdepolarizations in human atrial myocytes
title	Spatial distribution of calcium sparks determines their ability to induce afterdepolarizations in human atrial myocytes
spellingShingle	Spatial distribution of calcium sparks determines their ability to induce afterdepolarizations in human atrial myocytes Tarifa Lora, Carmen Atrial fibrillation Ryanodine--Receptors Atrial fibrillation Human atrial myocyte Ryanodine receptor Sarcoplasmic reticulum Transient inward currents Fibril·lació auricular Rianodina--Receptors Àrees temàtiques de la UPC::Física
title_short	Spatial distribution of calcium sparks determines their ability to induce afterdepolarizations in human atrial myocytes
title_full	Spatial distribution of calcium sparks determines their ability to induce afterdepolarizations in human atrial myocytes
title_fullStr	Spatial distribution of calcium sparks determines their ability to induce afterdepolarizations in human atrial myocytes
title_full_unstemmed	Spatial distribution of calcium sparks determines their ability to induce afterdepolarizations in human atrial myocytes
title_sort	Spatial distribution of calcium sparks determines their ability to induce afterdepolarizations in human atrial myocytes
dc.creator.none.fl_str_mv	Tarifa Lora, Carmen Vallmitjana Lees, Alexander Jiménez Sábado, Verónica Marchena Angos, Miquel Llach, Anna Herraiz Martínez, Adela Nolla Colomer, Carme Ginel Iglesias, Antonino Montiel Dacosta, José Antonio Ciruela, Francisco Echebarría Domínguez, Blas\|\|\|0000-0003-0503-1781 Benítez Iglesias, Raúl\|\|\|0000-0002-8782-9406 Cinca Cuscullola, Juan Maria Hove-Madsen, Leif\|\|\|0000-0001-5493-3998
author	Tarifa Lora, Carmen
author_facet	Tarifa Lora, Carmen Vallmitjana Lees, Alexander Jiménez Sábado, Verónica Marchena Angos, Miquel Llach, Anna Herraiz Martínez, Adela Nolla Colomer, Carme Ginel Iglesias, Antonino Montiel Dacosta, José Antonio Ciruela, Francisco Echebarría Domínguez, Blas\|\|\|0000-0003-0503-1781 Benítez Iglesias, Raúl\|\|\|0000-0002-8782-9406 Cinca Cuscullola, Juan Maria Hove-Madsen, Leif\|\|\|0000-0001-5493-3998
author_role	author
author2	Vallmitjana Lees, Alexander Jiménez Sábado, Verónica Marchena Angos, Miquel Llach, Anna Herraiz Martínez, Adela Nolla Colomer, Carme Ginel Iglesias, Antonino Montiel Dacosta, José Antonio Ciruela, Francisco Echebarría Domínguez, Blas\|\|\|0000-0003-0503-1781 Benítez Iglesias, Raúl\|\|\|0000-0002-8782-9406 Cinca Cuscullola, Juan Maria Hove-Madsen, Leif\|\|\|0000-0001-5493-3998
author2_role	author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Atrial fibrillation Ryanodine--Receptors Atrial fibrillation Human atrial myocyte Ryanodine receptor Sarcoplasmic reticulum Transient inward currents Fibril·lació auricular Rianodina--Receptors Àrees temàtiques de la UPC::Física
topic	Atrial fibrillation Ryanodine--Receptors Atrial fibrillation Human atrial myocyte Ryanodine receptor Sarcoplasmic reticulum Transient inward currents Fibril·lació auricular Rianodina--Receptors Àrees temàtiques de la UPC::Física
description	Analysis of the spatio-temporal distribution of calcium sparks showed a preferential increase in sparks near the sarcolemma in atrial myocytes from patients with atrial fibrillation (AF), linked to higher ryanodine receptor (RyR2) phosphorylation at s2808 and lower calsequestrin-2 levels. Mathematical modeling, incorporating modulation of RyR2 gating, showed that only the observed combinations of RyR2 phosphorylation and calsequestrin-2 levels can account for the spatio-temporal distribution of sparks in patients with and without AF. Furthermore, we demonstrate that preferential calcium release near the sarcolemma is key to a higher incidence and amplitude of afterdepolarizations in atrial myocytes from patients with AF.
publishDate	2023
dc.date.none.fl_str_mv	2023 2023-01-01 2024 2024-02-09
dc.type.none.fl_str_mv	journal article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://hdl.handle.net/2117/401668 https://dx.doi.org/10.1016/j.jacbts.2022.07.013
url	https://hdl.handle.net/2117/401668 https://dx.doi.org/10.1016/j.jacbts.2022.07.013
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	Elsevier
publisher.none.fl_str_mv	Elsevier
dc.source.none.fl_str_mv	reponame:UPCommons. Portal del coneixement obert de la UPC instname:Universitat Politècnica de Catalunya (UPC)
instname_str	Universitat Politècnica de Catalunya (UPC)
reponame_str	UPCommons. Portal del coneixement obert de la UPC
collection	UPCommons. Portal del coneixement obert de la UPC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15,301629

Spatial distribution of calcium sparks determines their ability to induce afterdepolarizations in human atrial myocytes

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