Spatial distribution of calcium sparks determines their ability to induce afterdepolarizations in human atrial myocytes

Analysis of the spatio-temporal distribution of calcium sparks showed a preferential increase in sparks near the sarcolemma in atrial myocytes from patients with atrial fibrillation (AF), linked to higher ryanodine receptor (RyR2) phosphorylation at s2808 and lower calsequestrin-2 levels. Mathematic...

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Detalles Bibliográficos
Autores: Tarifa Lora, Carmen, Vallmitjana Lees, Alexander, Jiménez Sábado, Verónica, Marchena Angos, Miquel, Llach, Anna, Herraiz Martínez, Adela, Nolla Colomer, Carme, Ginel Iglesias, Antonino, Montiel Dacosta, José Antonio, Ciruela, Francisco, Echebarría Domínguez, Blas|||0000-0003-0503-1781, Benítez Iglesias, Raúl|||0000-0002-8782-9406, Cinca Cuscullola, Juan Maria, Hove-Madsen, Leif|||0000-0001-5493-3998
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universitat Politècnica de Catalunya (UPC)
Repositorio:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglés
OAI Identifier:oai:upcommons.upc.edu:2117/401668
Acceso en línea:https://hdl.handle.net/2117/401668
https://dx.doi.org/10.1016/j.jacbts.2022.07.013
Access Level:acceso abierto
Palabra clave:Atrial fibrillation
Ryanodine--Receptors
Human atrial myocyte
Ryanodine receptor
Sarcoplasmic reticulum
Transient inward currents
Fibril·lació auricular
Rianodina--Receptors
Àrees temàtiques de la UPC::Física
Descripción
Sumario:Analysis of the spatio-temporal distribution of calcium sparks showed a preferential increase in sparks near the sarcolemma in atrial myocytes from patients with atrial fibrillation (AF), linked to higher ryanodine receptor (RyR2) phosphorylation at s2808 and lower calsequestrin-2 levels. Mathematical modeling, incorporating modulation of RyR2 gating, showed that only the observed combinations of RyR2 phosphorylation and calsequestrin-2 levels can account for the spatio-temporal distribution of sparks in patients with and without AF. Furthermore, we demonstrate that preferential calcium release near the sarcolemma is key to a higher incidence and amplitude of afterdepolarizations in atrial myocytes from patients with AF.