Spatial distribution of calcium sparks determines their ability to induce afterdepolarizations in human atrial myocytes
Analysis of the spatio-temporal distribution of calcium sparks showed a preferential increase in sparks near the sarcolemma in atrial myocytes from patients with atrial fibrillation (AF), linked to higher ryanodine receptor (RyR2) phosphorylation at s2808 and lower calsequestrin-2 levels. Mathematic...
| Autores: | , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Universitat Politècnica de Catalunya (UPC) |
| Repositorio: | UPCommons. Portal del coneixement obert de la UPC |
| Idioma: | inglés |
| OAI Identifier: | oai:upcommons.upc.edu:2117/401668 |
| Acceso en línea: | https://hdl.handle.net/2117/401668 https://dx.doi.org/10.1016/j.jacbts.2022.07.013 |
| Access Level: | acceso abierto |
| Palabra clave: | Atrial fibrillation Ryanodine--Receptors Human atrial myocyte Ryanodine receptor Sarcoplasmic reticulum Transient inward currents Fibril·lació auricular Rianodina--Receptors Àrees temàtiques de la UPC::Física |
| Sumario: | Analysis of the spatio-temporal distribution of calcium sparks showed a preferential increase in sparks near the sarcolemma in atrial myocytes from patients with atrial fibrillation (AF), linked to higher ryanodine receptor (RyR2) phosphorylation at s2808 and lower calsequestrin-2 levels. Mathematical modeling, incorporating modulation of RyR2 gating, showed that only the observed combinations of RyR2 phosphorylation and calsequestrin-2 levels can account for the spatio-temporal distribution of sparks in patients with and without AF. Furthermore, we demonstrate that preferential calcium release near the sarcolemma is key to a higher incidence and amplitude of afterdepolarizations in atrial myocytes from patients with AF. |
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