The food-associated resistome is shaped by processing and production environments
[EN] Food production systems may act as transmission routes for antimicrobial-resistant (AMR) bacteria and AMR genes (AMRGs) to humans. However, the food resistome remains poorly characterized. Here 1,780 raw-material (milk, brine, fresh meat and so on), end-product (cheese, fish, meat products and...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2025 |
| País: | España |
| Recursos: | Universidad de León |
| Repositorio: | BULERIA. Repositorio Institucional de la Universidad de León |
| OAI Identifier: | oai:buleria.unileon.es:10612/26275 |
| Acesso em linha: | https://www.nature.com/articles/s41564-025-02059-8 https://hdl.handle.net/10612/26275 |
| Access Level: | acceso abierto |
| Palavra-chave: | Tecnología de los alimentos Food-associated resistome Antimicrobial-resistant (AMR) Bacteria and AMR genes (AMRGs) Food production systems 3309.90 Microbiología de Alimentos 3309 Tecnología de Los Alimentos |
| id |
ES_e8ca84f8e7eac80d86af939e73d91ed1 |
|---|---|
| oai_identifier_str |
oai:buleria.unileon.es:10612/26275 |
| network_acronym_str |
ES |
| network_name_str |
España |
| repository_id_str |
|
| spelling |
The food-associated resistome is shaped by processing and production environmentsQuijada, Narciso M.Cobo Díaz, José FranciscoValentino, VincenzoBarcenilla Canduela, CoralDe Filippis, FrancescaCabrera Rubio, RaúlCarlino, NiccolòPinto, FedericaDzieciol, MonikaCalvete Torre, InésSabater, CarlosRubino, FrancescoKnobloch, StephenSkírnisdóttir, SigurlaugRuiz, LorenaLópez Fernández, María MercedesPrieto Maradona, MiguelMarteinsson, Viggó ThórMargolles, AbelardoSegata, NicolaCotter, Paul D.Wagner, MartinErcolini, DaniloÁlvarez Ordóñez, AvelinoTecnología de los alimentosFood-associated resistomeAntimicrobial-resistant (AMR)Bacteria and AMR genes (AMRGs)Food production systems3309.90 Microbiología de Alimentos3309 Tecnología de Los Alimentos[EN] Food production systems may act as transmission routes for antimicrobial-resistant (AMR) bacteria and AMR genes (AMRGs) to humans. However, the food resistome remains poorly characterized. Here 1,780 raw-material (milk, brine, fresh meat and so on), end-product (cheese, fish, meat products and vegetables) and surface (processing, cooling, smoking, ripening and packing rooms) samples from 113 food processing facilities were subjected to whole-metagenome sequencing. Assembly-free analyses demonstrated that >70% of all known AMRGs, including many predicted to confer resistance to critically important antibiotics, circulate throughout food production chains, with those conferring resistance to tetracyclines, β-lactams, aminoglycosides and macrolides being the most abundant overall. An assembly-based analysis highlighted that bacteria from the ESKAPEE group, together with Staphylococcus equorum and Acinetobacter johnsonii, were the main AMRG carriers. Further evaluation demonstrated that ~40% of the AMRGs were associated with mobile genetic elements, mainly plasmids. These findings will help guide the appropriate use of biocides and other antimicrobials in food production settings when designing efficient antimicrobial stewardship policiesSIThis work was funded by the European Commission under the European Union’s Horizon 2020 research and innovation programme under grant agreement no. 818368 (MASTER). N.M.Q. is currently funded under the Generation D initiative, promoted by Red.es, an organization attached to the Ministry for Digital Transformation and the Civil Service, for the attraction and retention of talent through grants and training contracts, financed by the Recovery, Transformation and Resilience Plan through the European Union’s Next Generation funds (ref. MMT24-IBFG-01). C.B. is grateful to Junta de Castilla y León and the European Social Fund for awarding her a predoctoral grant (grant no. BOCYL-D-07072020-6). The COMET-K1 competence centre FFoQSI (number 881882) is funded by the Austrian federal ministries BMK, BMDW and the Austrian provinces Lower Austria, Upper Austria and Vienna within the scope of COMET - Competence Centers for Excellent Technologies. The program COMET is handled by the Austrian Research Promotion Agency, FFGNature ResearchTecnologia de los AlimentosFacultad de Veterinaria2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://www.nature.com/articles/s41564-025-02059-8https://hdl.handle.net/10612/26275reponame:BULERIA. Repositorio Institucional de la Universidad de Leóninstname:Universidad de LeónIngléshttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:buleria.unileon.es:10612/262752026-06-24T12:43:27Z |
| dc.title.none.fl_str_mv |
The food-associated resistome is shaped by processing and production environments |
| title |
The food-associated resistome is shaped by processing and production environments |
| spellingShingle |
The food-associated resistome is shaped by processing and production environments Quijada, Narciso M. Tecnología de los alimentos Food-associated resistome Antimicrobial-resistant (AMR) Bacteria and AMR genes (AMRGs) Food production systems 3309.90 Microbiología de Alimentos 3309 Tecnología de Los Alimentos |
| title_short |
The food-associated resistome is shaped by processing and production environments |
| title_full |
The food-associated resistome is shaped by processing and production environments |
| title_fullStr |
The food-associated resistome is shaped by processing and production environments |
| title_full_unstemmed |
The food-associated resistome is shaped by processing and production environments |
| title_sort |
The food-associated resistome is shaped by processing and production environments |
| dc.creator.none.fl_str_mv |
Quijada, Narciso M. Cobo Díaz, José Francisco Valentino, Vincenzo Barcenilla Canduela, Coral De Filippis, Francesca Cabrera Rubio, Raúl Carlino, Niccolò Pinto, Federica Dzieciol, Monika Calvete Torre, Inés Sabater, Carlos Rubino, Francesco Knobloch, Stephen Skírnisdóttir, Sigurlaug Ruiz, Lorena López Fernández, María Mercedes Prieto Maradona, Miguel Marteinsson, Viggó Thór Margolles, Abelardo Segata, Nicola Cotter, Paul D. Wagner, Martin Ercolini, Danilo Álvarez Ordóñez, Avelino |
| author |
Quijada, Narciso M. |
| author_facet |
Quijada, Narciso M. Cobo Díaz, José Francisco Valentino, Vincenzo Barcenilla Canduela, Coral De Filippis, Francesca Cabrera Rubio, Raúl Carlino, Niccolò Pinto, Federica Dzieciol, Monika Calvete Torre, Inés Sabater, Carlos Rubino, Francesco Knobloch, Stephen Skírnisdóttir, Sigurlaug Ruiz, Lorena López Fernández, María Mercedes Prieto Maradona, Miguel Marteinsson, Viggó Thór Margolles, Abelardo Segata, Nicola Cotter, Paul D. Wagner, Martin Ercolini, Danilo Álvarez Ordóñez, Avelino |
| author_role |
author |
| author2 |
Cobo Díaz, José Francisco Valentino, Vincenzo Barcenilla Canduela, Coral De Filippis, Francesca Cabrera Rubio, Raúl Carlino, Niccolò Pinto, Federica Dzieciol, Monika Calvete Torre, Inés Sabater, Carlos Rubino, Francesco Knobloch, Stephen Skírnisdóttir, Sigurlaug Ruiz, Lorena López Fernández, María Mercedes Prieto Maradona, Miguel Marteinsson, Viggó Thór Margolles, Abelardo Segata, Nicola Cotter, Paul D. Wagner, Martin Ercolini, Danilo Álvarez Ordóñez, Avelino |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Tecnologia de los Alimentos Facultad de Veterinaria |
| dc.subject.none.fl_str_mv |
Tecnología de los alimentos Food-associated resistome Antimicrobial-resistant (AMR) Bacteria and AMR genes (AMRGs) Food production systems 3309.90 Microbiología de Alimentos 3309 Tecnología de Los Alimentos |
| topic |
Tecnología de los alimentos Food-associated resistome Antimicrobial-resistant (AMR) Bacteria and AMR genes (AMRGs) Food production systems 3309.90 Microbiología de Alimentos 3309 Tecnología de Los Alimentos |
| description |
[EN] Food production systems may act as transmission routes for antimicrobial-resistant (AMR) bacteria and AMR genes (AMRGs) to humans. However, the food resistome remains poorly characterized. Here 1,780 raw-material (milk, brine, fresh meat and so on), end-product (cheese, fish, meat products and vegetables) and surface (processing, cooling, smoking, ripening and packing rooms) samples from 113 food processing facilities were subjected to whole-metagenome sequencing. Assembly-free analyses demonstrated that >70% of all known AMRGs, including many predicted to confer resistance to critically important antibiotics, circulate throughout food production chains, with those conferring resistance to tetracyclines, β-lactams, aminoglycosides and macrolides being the most abundant overall. An assembly-based analysis highlighted that bacteria from the ESKAPEE group, together with Staphylococcus equorum and Acinetobacter johnsonii, were the main AMRG carriers. Further evaluation demonstrated that ~40% of the AMRGs were associated with mobile genetic elements, mainly plasmids. These findings will help guide the appropriate use of biocides and other antimicrobials in food production settings when designing efficient antimicrobial stewardship policies |
| publishDate |
2025 |
| dc.date.none.fl_str_mv |
2025 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://www.nature.com/articles/s41564-025-02059-8 https://hdl.handle.net/10612/26275 |
| url |
https://www.nature.com/articles/s41564-025-02059-8 https://hdl.handle.net/10612/26275 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.rights.none.fl_str_mv |
http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Nature Research |
| publisher.none.fl_str_mv |
Nature Research |
| dc.source.none.fl_str_mv |
reponame:BULERIA. Repositorio Institucional de la Universidad de León instname:Universidad de León |
| instname_str |
Universidad de León |
| reponame_str |
BULERIA. Repositorio Institucional de la Universidad de León |
| collection |
BULERIA. Repositorio Institucional de la Universidad de León |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
|
| _version_ |
1869422972363603968 |
| score |
15.811543 |