The food-associated resistome is shaped by processing and production environments

[EN] Food production systems may act as transmission routes for antimicrobial-resistant (AMR) bacteria and AMR genes (AMRGs) to humans. However, the food resistome remains poorly characterized. Here 1,780 raw-material (milk, brine, fresh meat and so on), end-product (cheese, fish, meat products and...

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Detalles Bibliográficos
Autores: Quijada, Narciso M., Cobo Díaz, José Francisco, Valentino, Vincenzo, Barcenilla Canduela, Coral, De Filippis, Francesca, Cabrera Rubio, Raúl, Carlino, Niccolò, Pinto, Federica, Dzieciol, Monika, Calvete Torre, Inés, Sabater, Carlos, Rubino, Francesco, Knobloch, Stephen, Skírnisdóttir, Sigurlaug, Ruiz, Lorena, López Fernández, María Mercedes, Prieto Maradona, Miguel, Marteinsson, Viggó Thór, Margolles, Abelardo, Segata, Nicola, Cotter, Paul D., Wagner, Martin, Ercolini, Danilo, Álvarez Ordóñez, Avelino
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Universidad de León
Repositorio:BULERIA. Repositorio Institucional de la Universidad de León
OAI Identifier:oai:buleria.unileon.es:10612/26275
Acceso en línea:https://www.nature.com/articles/s41564-025-02059-8
https://hdl.handle.net/10612/26275
Access Level:acceso abierto
Palabra clave:Tecnología de los alimentos
Food-associated resistome
Antimicrobial-resistant (AMR)
Bacteria and AMR genes (AMRGs)
Food production systems
3309.90 Microbiología de Alimentos
3309 Tecnología de Los Alimentos
Descripción
Sumario:[EN] Food production systems may act as transmission routes for antimicrobial-resistant (AMR) bacteria and AMR genes (AMRGs) to humans. However, the food resistome remains poorly characterized. Here 1,780 raw-material (milk, brine, fresh meat and so on), end-product (cheese, fish, meat products and vegetables) and surface (processing, cooling, smoking, ripening and packing rooms) samples from 113 food processing facilities were subjected to whole-metagenome sequencing. Assembly-free analyses demonstrated that >70% of all known AMRGs, including many predicted to confer resistance to critically important antibiotics, circulate throughout food production chains, with those conferring resistance to tetracyclines, β-lactams, aminoglycosides and macrolides being the most abundant overall. An assembly-based analysis highlighted that bacteria from the ESKAPEE group, together with Staphylococcus equorum and Acinetobacter johnsonii, were the main AMRG carriers. Further evaluation demonstrated that ~40% of the AMRGs were associated with mobile genetic elements, mainly plasmids. These findings will help guide the appropriate use of biocides and other antimicrobials in food production settings when designing efficient antimicrobial stewardship policies

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