Association Between Oxidative-Inflammation Biomarkers and Incident Chronic Kidney Disease in People with High Cardiovascular Risk: A Nested Case-Control Study.

Quetglas-Llabrés, Maria Magdalena; Díaz-López, Andrés; Bouzas, Cristina; Monserrat Mesquida, Margalida; Salas-Salvadó, Jordi; Ruiz-Canela, Miguel; Martínez, J Alfredo; Santos-Lozano, José Manuel; García, Silvia; Estruch, Ramon; López-Miranda, José; Romaguera, Dora; Tinahones, Francisco J; García-Fernández, Marcos; Mas-Fontao, Sebastián; Matía-Martín, Pilar; Vioque, Jesús; Bueno, Aurora; Babio, Nancy; Tur, Josep A.; Sureda, Antoni

Association Between Oxidative-Inflammation Biomarkers and Incident Chronic Kidney Disease in People with High Cardiovascular Risk: A Nested Case-Control Study.

: To assess oxidative-inflammatory biomarker prediction of incident CKD after 1-year follow-up in a population with overweight/obesity and metabolic syndrome. : Prospective nested case-control study comprising 117 CKD incident cases and 117 matched controls free of CKD after 1-year follow-up conduct...

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Autores:	Quetglas-Llabrés, Maria Magdalena, Díaz-López, Andrés, Bouzas, Cristina, Monserrat Mesquida, Margalida, Salas-Salvadó, Jordi, Ruiz-Canela, Miguel, Martínez, J Alfredo, Santos-Lozano, José Manuel, García, Silvia, Estruch, Ramon, López-Miranda, José, Romaguera, Dora, Tinahones, Francisco J, García-Fernández, Marcos, Mas-Fontao, Sebastián, Matía-Martín, Pilar, Vioque, Jesús, Bueno, Aurora, Babio, Nancy, Tur, Josep A., Sureda, Antoni
Tipo de recurso:	artículo
Fecha de publicación:	2025
País:	España
Institución:	Conselleria de Salut i Consum del Govern de les Illes Balears
Repositorio:	Docusalut
Idioma:	inglés
OAI Identifier:	oai:docusalut.com:20.500.13003/25897
Acceso en línea:	https://hdl.handle.net/20.500.13003/25897
Access Level:	acceso abierto
Palabra clave:	Glomerular Filtration Rate Glomerular Filtration Barrier Inflammation Kidney Metabolic Syndrome Oxidative Stress Tasa de Filtración Glomerular Barrera de Filtración Glomerular Inflamación Riñón Síndrome Metabólico Estrés Oxidativo glomerular filtration inflammation kidney dysfunction metabolic syndrome oxidative stress

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spelling	Association Between Oxidative-Inflammation Biomarkers and Incident Chronic Kidney Disease in People with High Cardiovascular Risk: A Nested Case-Control Study.Quetglas-Llabrés, Maria MagdalenaDíaz-López, AndrésBouzas, CristinaMonserrat Mesquida, MargalidaSalas-Salvadó, JordiRuiz-Canela, MiguelMartínez, J AlfredoSantos-Lozano, José ManuelGarcía, SilviaEstruch, RamonLópez-Miranda, JoséRomaguera, DoraTinahones, Francisco JGarcía-Fernández, MarcosMas-Fontao, SebastiánMatía-Martín, PilarVioque, JesúsBueno, AuroraBabio, NancyTur, Josep A.Sureda, AntoniGlomerular Filtration RateGlomerular Filtration BarrierInflammationKidneyMetabolic SyndromeOxidative StressTasa de Filtración GlomerularBarrera de Filtración GlomerularInflamaciónRiñónSíndrome MetabólicoEstrés Oxidativoglomerular filtrationinflammationkidney dysfunctionmetabolic syndromeoxidative stress: To assess oxidative-inflammatory biomarker prediction of incident CKD after 1-year follow-up in a population with overweight/obesity and metabolic syndrome. : Prospective nested case-control study comprising 117 CKD incident cases and 117 matched controls free of CKD after 1-year follow-up conducted in 55-75-year-old participants. Controls were time-matched 1:1 to cases by intervention group, age (≤65 vs. >65 years), and sex. Serum creatinine (SCr), cystatin C (CyC), and urine albumin-to-creatinine ratio (UACR) were measured at baseline, and CKD Epidemiology Collaboration equations for Caucasians were used to assess SCr, CyC, and CyC-SCr-based estimated Glomerular Filtration Rate (eGFR). Baseline levels of malondialdehyde (MDA), carbonyls, tumour necrosis factor alpha (TNFα), interleukin (IL)-1β, IL-1ra, IL-6, monocyte chemoattractant protein 1 (MCP-1), and leptin were determined from fasting serum samples. An inflammatory-oxidative stress score based on these biomarkers was calculated. Incident CKD was defined by eGFR-SCr <60 mL/min/1.73 m, and/or UACR ≥30 mg/g in the absence of CKD at baseline. : UACR positively correlated with pro-inflammatory markers (IL-1β; TNFα) and oxidative damage marker (MDA); eGFR-cyC showed negative correlations with IL-1β and IL-1ra, and eGFR-SCr with leptin. The odds ratios (OR; 95% CI) for incident CKD in the highest vs. the lowest tertile of IL-1ra IL-6 and TNFα were (2.22; 1.22-4.04), (7.03; 2.88-17.14), and (3.79; 1.79-8.02), respectively. The inflammatory-oxidative stress score was associated with incident CKD (OR per 1-SD increment: 2.06; 1.49-2.83). : Inflammatory/oxidative stress is associated with CKD incidence in individuals with high cardiovascular risk, underscoring the importance in identify early inflammation to prevent this disease.MDPI20252025-01-0120252025-01-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.13003/25897reponame:Docusalutinstname:Conselleria de Salut i Consum del Govern de les Illes BalearsInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:docusalut.com:20.500.13003/258972026-06-22T12:44:07Z
dc.title.none.fl_str_mv	Association Between Oxidative-Inflammation Biomarkers and Incident Chronic Kidney Disease in People with High Cardiovascular Risk: A Nested Case-Control Study.
title	Association Between Oxidative-Inflammation Biomarkers and Incident Chronic Kidney Disease in People with High Cardiovascular Risk: A Nested Case-Control Study.
spellingShingle	Association Between Oxidative-Inflammation Biomarkers and Incident Chronic Kidney Disease in People with High Cardiovascular Risk: A Nested Case-Control Study. Quetglas-Llabrés, Maria Magdalena Glomerular Filtration Rate Glomerular Filtration Barrier Inflammation Kidney Metabolic Syndrome Oxidative Stress Tasa de Filtración Glomerular Barrera de Filtración Glomerular Inflamación Riñón Síndrome Metabólico Estrés Oxidativo glomerular filtration inflammation kidney dysfunction metabolic syndrome oxidative stress
title_short	Association Between Oxidative-Inflammation Biomarkers and Incident Chronic Kidney Disease in People with High Cardiovascular Risk: A Nested Case-Control Study.
title_full	Association Between Oxidative-Inflammation Biomarkers and Incident Chronic Kidney Disease in People with High Cardiovascular Risk: A Nested Case-Control Study.
title_fullStr	Association Between Oxidative-Inflammation Biomarkers and Incident Chronic Kidney Disease in People with High Cardiovascular Risk: A Nested Case-Control Study.
title_full_unstemmed	Association Between Oxidative-Inflammation Biomarkers and Incident Chronic Kidney Disease in People with High Cardiovascular Risk: A Nested Case-Control Study.
title_sort	Association Between Oxidative-Inflammation Biomarkers and Incident Chronic Kidney Disease in People with High Cardiovascular Risk: A Nested Case-Control Study.
dc.creator.none.fl_str_mv	Quetglas-Llabrés, Maria Magdalena Díaz-López, Andrés Bouzas, Cristina Monserrat Mesquida, Margalida Salas-Salvadó, Jordi Ruiz-Canela, Miguel Martínez, J Alfredo Santos-Lozano, José Manuel García, Silvia Estruch, Ramon López-Miranda, José Romaguera, Dora Tinahones, Francisco J García-Fernández, Marcos Mas-Fontao, Sebastián Matía-Martín, Pilar Vioque, Jesús Bueno, Aurora Babio, Nancy Tur, Josep A. Sureda, Antoni
author	Quetglas-Llabrés, Maria Magdalena
author_facet	Quetglas-Llabrés, Maria Magdalena Díaz-López, Andrés Bouzas, Cristina Monserrat Mesquida, Margalida Salas-Salvadó, Jordi Ruiz-Canela, Miguel Martínez, J Alfredo Santos-Lozano, José Manuel García, Silvia Estruch, Ramon López-Miranda, José Romaguera, Dora Tinahones, Francisco J García-Fernández, Marcos Mas-Fontao, Sebastián Matía-Martín, Pilar Vioque, Jesús Bueno, Aurora Babio, Nancy Tur, Josep A. Sureda, Antoni
author_role	author
author2	Díaz-López, Andrés Bouzas, Cristina Monserrat Mesquida, Margalida Salas-Salvadó, Jordi Ruiz-Canela, Miguel Martínez, J Alfredo Santos-Lozano, José Manuel García, Silvia Estruch, Ramon López-Miranda, José Romaguera, Dora Tinahones, Francisco J García-Fernández, Marcos Mas-Fontao, Sebastián Matía-Martín, Pilar Vioque, Jesús Bueno, Aurora Babio, Nancy Tur, Josep A. Sureda, Antoni
author2_role	author author author author author author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv	Glomerular Filtration Rate Glomerular Filtration Barrier Inflammation Kidney Metabolic Syndrome Oxidative Stress Tasa de Filtración Glomerular Barrera de Filtración Glomerular Inflamación Riñón Síndrome Metabólico Estrés Oxidativo glomerular filtration inflammation kidney dysfunction metabolic syndrome oxidative stress
topic	Glomerular Filtration Rate Glomerular Filtration Barrier Inflammation Kidney Metabolic Syndrome Oxidative Stress Tasa de Filtración Glomerular Barrera de Filtración Glomerular Inflamación Riñón Síndrome Metabólico Estrés Oxidativo glomerular filtration inflammation kidney dysfunction metabolic syndrome oxidative stress
description	: To assess oxidative-inflammatory biomarker prediction of incident CKD after 1-year follow-up in a population with overweight/obesity and metabolic syndrome. : Prospective nested case-control study comprising 117 CKD incident cases and 117 matched controls free of CKD after 1-year follow-up conducted in 55-75-year-old participants. Controls were time-matched 1:1 to cases by intervention group, age (≤65 vs. >65 years), and sex. Serum creatinine (SCr), cystatin C (CyC), and urine albumin-to-creatinine ratio (UACR) were measured at baseline, and CKD Epidemiology Collaboration equations for Caucasians were used to assess SCr, CyC, and CyC-SCr-based estimated Glomerular Filtration Rate (eGFR). Baseline levels of malondialdehyde (MDA), carbonyls, tumour necrosis factor alpha (TNFα), interleukin (IL)-1β, IL-1ra, IL-6, monocyte chemoattractant protein 1 (MCP-1), and leptin were determined from fasting serum samples. An inflammatory-oxidative stress score based on these biomarkers was calculated. Incident CKD was defined by eGFR-SCr <60 mL/min/1.73 m, and/or UACR ≥30 mg/g in the absence of CKD at baseline. : UACR positively correlated with pro-inflammatory markers (IL-1β; TNFα) and oxidative damage marker (MDA); eGFR-cyC showed negative correlations with IL-1β and IL-1ra, and eGFR-SCr with leptin. The odds ratios (OR; 95% CI) for incident CKD in the highest vs. the lowest tertile of IL-1ra IL-6 and TNFα were (2.22; 1.22-4.04), (7.03; 2.88-17.14), and (3.79; 1.79-8.02), respectively. The inflammatory-oxidative stress score was associated with incident CKD (OR per 1-SD increment: 2.06; 1.49-2.83). : Inflammatory/oxidative stress is associated with CKD incidence in individuals with high cardiovascular risk, underscoring the importance in identify early inflammation to prevent this disease.
publishDate	2025
dc.date.none.fl_str_mv	2025 2025-01-01 2025 2025-01-01
dc.type.none.fl_str_mv	research article http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://hdl.handle.net/20.500.13003/25897
url	https://hdl.handle.net/20.500.13003/25897
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	MDPI
publisher.none.fl_str_mv	MDPI
dc.source.none.fl_str_mv	reponame:Docusalut instname:Conselleria de Salut i Consum del Govern de les Illes Balears
instname_str	Conselleria de Salut i Consum del Govern de les Illes Balears
reponame_str	Docusalut
collection	Docusalut
repository.name.fl_str_mv
repository.mail.fl_str_mv
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Association Between Oxidative-Inflammation Biomarkers and Incident Chronic Kidney Disease in People with High Cardiovascular Risk: A Nested Case-Control Study.

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