Association Between Oxidative-Inflammation Biomarkers and Incident Chronic Kidney Disease in People with High Cardiovascular Risk: A Nested Case-Control Study.

: To assess oxidative-inflammatory biomarker prediction of incident CKD after 1-year follow-up in a population with overweight/obesity and metabolic syndrome. : Prospective nested case-control study comprising 117 CKD incident cases and 117 matched controls free of CKD after 1-year follow-up conduct...

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Detalles Bibliográficos
Autores: Quetglas-Llabrés, Maria Magdalena, Díaz-López, Andrés, Bouzas, Cristina, Monserrat Mesquida, Margalida, Salas-Salvadó, Jordi, Ruiz-Canela, Miguel, Martínez, J Alfredo, Santos-Lozano, José Manuel, García, Silvia, Estruch, Ramon, López-Miranda, José, Romaguera, Dora, Tinahones, Francisco J, García-Fernández, Marcos, Mas-Fontao, Sebastián, Matía-Martín, Pilar, Vioque, Jesús, Bueno, Aurora, Babio, Nancy, Tur, Josep A., Sureda, Antoni
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Conselleria de Salut i Consum del Govern de les Illes Balears
Repositorio:Docusalut
Idioma:inglés
OAI Identifier:oai:docusalut.com:20.500.13003/25897
Acceso en línea:https://hdl.handle.net/20.500.13003/25897
Access Level:acceso abierto
Palabra clave:Glomerular Filtration Rate
Glomerular Filtration Barrier
Inflammation
Kidney
Metabolic Syndrome
Oxidative Stress
Tasa de Filtración Glomerular
Barrera de Filtración Glomerular
Inflamación
Riñón
Síndrome Metabólico
Estrés Oxidativo
glomerular filtration
inflammation
kidney dysfunction
metabolic syndrome
oxidative stress
Descripción
Sumario:: To assess oxidative-inflammatory biomarker prediction of incident CKD after 1-year follow-up in a population with overweight/obesity and metabolic syndrome. : Prospective nested case-control study comprising 117 CKD incident cases and 117 matched controls free of CKD after 1-year follow-up conducted in 55-75-year-old participants. Controls were time-matched 1:1 to cases by intervention group, age (≤65 vs. >65 years), and sex. Serum creatinine (SCr), cystatin C (CyC), and urine albumin-to-creatinine ratio (UACR) were measured at baseline, and CKD Epidemiology Collaboration equations for Caucasians were used to assess SCr, CyC, and CyC-SCr-based estimated Glomerular Filtration Rate (eGFR). Baseline levels of malondialdehyde (MDA), carbonyls, tumour necrosis factor alpha (TNFα), interleukin (IL)-1β, IL-1ra, IL-6, monocyte chemoattractant protein 1 (MCP-1), and leptin were determined from fasting serum samples. An inflammatory-oxidative stress score based on these biomarkers was calculated. Incident CKD was defined by eGFR-SCr <60 mL/min/1.73 m, and/or UACR ≥30 mg/g in the absence of CKD at baseline. : UACR positively correlated with pro-inflammatory markers (IL-1β; TNFα) and oxidative damage marker (MDA); eGFR-cyC showed negative correlations with IL-1β and IL-1ra, and eGFR-SCr with leptin. The odds ratios (OR; 95% CI) for incident CKD in the highest vs. the lowest tertile of IL-1ra IL-6 and TNFα were (2.22; 1.22-4.04), (7.03; 2.88-17.14), and (3.79; 1.79-8.02), respectively. The inflammatory-oxidative stress score was associated with incident CKD (OR per 1-SD increment: 2.06; 1.49-2.83). : Inflammatory/oxidative stress is associated with CKD incidence in individuals with high cardiovascular risk, underscoring the importance in identify early inflammation to prevent this disease.

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