Immune dysregulation and the increased risk of complications and mortality following respiratory tract infections in adults with Down dyndrome

The risk of severe outcomes following respiratory tract infections is significantly increased in individuals over 60 years, especially in those with chronic medical conditions, i.e., hypertension, diabetes, cardiovascular disease, dementia, chronic respiratory disease, and cancer. Down Syndrome (DS)...

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Detalles Bibliográficos
Autores: Illouz, Tomer, Biragyn, Arya, Iulita, Maria Florencia, Flores-Aguilar, Lisi, Dierssen, Mara, De Toma, Ilario, Antonarakis, Stylianos E., Yu, Eugene, Herault, Yann, Potier, Marie-Claude, Botté, Alexandra, Roper, Randall, Sredni, Benjamin, London, Jacqueline, Mobley, William, Strydom, Andre, Okun, Eitan
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/49092
Acceso en línea:http://hdl.handle.net/10230/49092
http://dx.doi.org/10.3389/fimmu.2021.621440
Access Level:acceso abierto
Palabra clave:COVID-19
Down syndrome
Hospitalization
Immune dysregulation
Interferon
Respiratory tract infections
Descripción
Sumario:The risk of severe outcomes following respiratory tract infections is significantly increased in individuals over 60 years, especially in those with chronic medical conditions, i.e., hypertension, diabetes, cardiovascular disease, dementia, chronic respiratory disease, and cancer. Down Syndrome (DS), the most prevalent intellectual disability, is caused by trisomy-21 in ~1:750 live births worldwide. Over the past few decades, a substantial body of evidence has accumulated, pointing at the occurrence of alterations, impairments, and subsequently dysfunction of the various components of the immune system in individuals with DS. This associates with increased vulnerability to respiratory tract infections in this population, such as the influenza virus, respiratory syncytial virus, SARS-CoV-2 (COVID-19), and bacterial pneumonias. To emphasize this link, here we comprehensively review the immunobiology of DS and its contribution to higher susceptibility to severe illness and mortality from respiratory tract infections.

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