Immune Dysregulation and the Increased Risk of Complications and Mortality Following Respiratory Tract Infections in Adults With Down Syndrome

The risk of severe outcomes following respiratory tract infections is significantly increased in individuals over 60 years, especially in those with chronic medical conditions, i.e., hypertension, diabetes, cardiovascular disease, dementia, chronic respiratory disease, and cancer. Down Syndrome (DS)...

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Detalhes bibliográficos
Autores: Illouz, Tomer, Biragyn, Arya, Iulita, M. Florencia|||0000-0002-3360-4498, Flores-Aguilar, Lisi, Dierssen, Mara|||0000-0003-0853-6865, De Toma, Ilario, Antonarakis, Stylianos E., Yu, Eugene, Herault, Yann|||0000-0001-7049-6900, Potier, Marie-Claude, Botté, Alexandra, Roper, Randall, Sredni, Benjamin, London, Jacqueline, Mobley, William, Strydom, Andre, Okun, Eitan|||0000-0001-8474-1487
Formato: artículo
Fecha de publicación:2021
País:España
Recursos:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:256498
Acesso em linha:https://ddd.uab.cat/record/256498
https://dx.doi.org/urn:doi:10.3389/fimmu.2021.621440
Access Level:acceso abierto
Palavra-chave:Down syndrome
Immune dysregulation
Hospitalization
Respiratory tract infections
Interferon
COVID-19
Descrição
Resumo:The risk of severe outcomes following respiratory tract infections is significantly increased in individuals over 60 years, especially in those with chronic medical conditions, i.e., hypertension, diabetes, cardiovascular disease, dementia, chronic respiratory disease, and cancer. Down Syndrome (DS), the most prevalent intellectual disability, is caused by trisomy-21 in ~1:750 live births worldwide. Over the past few decades, a substantial body of evidence has accumulated, pointing at the occurrence of alterations, impairments, and subsequently dysfunction of the various components of the immune system in individuals with DS. This associates with increased vulnerability to respiratory tract infections in this population, such as the influenza virus, respiratory syncytial virus, SARS-CoV-2 (COVID-19), and bacterial pneumonias. To emphasize this link, here we comprehensively review the immunobiology of DS and its contribution to higher susceptibility to severe illness and mortality from respiratory tract infections.

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