Specific Susceptibility to COVID-19 in Adults with Down Syndrome

The current SARS-CoV-2 outbreak, which causes COVID-19, is particularly devastating for individuals with chronic medical conditions, in particular those with Down Syndrome (DS) who often exhibit a higher prevalence of respiratory tract infections, immune dysregulation and potential complications. Th...

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Autores: Illouz, Tomer, Biragyn, Arya, Frenkel-Morgenstern, Milana, Weissberg, Orly, Gorohovski, Alessandro, Merzon, Eugene, Green, Ilan, Iulita, M. Florencia|||0000-0002-3360-4498, Flores-Aguilar, Lisi, del Mar Dierssen Sotos, Maria, De Toma, Ilario, Lifshitz, Hefziba, Antonarakis, Stylianos E., Yu, Eugene, Herault, Yann|||0000-0001-7049-6900, Potier, Marie-Claude, Botté, Alexandra, Roper, Randall, Sredni, Benjamin, Sarid, Ronit, London, Jacqueline, Mobley, William, Strydom, Andre, Okun, Eitan|||0000-0001-8474-1487
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:237380
Acceso en línea:https://ddd.uab.cat/record/237380
https://dx.doi.org/urn:doi:10.1007/s12017-021-08651-5
Access Level:acceso abierto
Palabra clave:COVID-19
Down syndrome
Immune dysregulation
SARS-CoV-2
Vaccine
Descripción
Sumario:The current SARS-CoV-2 outbreak, which causes COVID-19, is particularly devastating for individuals with chronic medical conditions, in particular those with Down Syndrome (DS) who often exhibit a higher prevalence of respiratory tract infections, immune dysregulation and potential complications. The incidence of Alzheimer's disease (AD) is much higher in DS than in the general population, possibly increasing further the risk of COVID-19 infection and its complications. Here we provide a biological overview with regard to specific susceptibility of individuals with DS to SARS-CoV-2 infection as well as data from a recent survey on the prevalence of COVID-19 among them. We see an urgent need to protect people with DS, especially those with AD, from COVID-19 and future pandemics and focus on developing protective measures, which also include interventions by health systems worldwide for reducing the negative social effects of long-term isolation and increased periods of hospitalization.

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