Early surfactant replacement guided by lung ultrasound in preterm newborns with RDS: the ULTRASURF randomised controlled trial
This study aimed to investigate whether using lung ultrasound (LUS) scores in premature newborns with respiratory distress syndrome (RDS) allows for earlier surfactant therapy (within the first 3 h of life) than using FiO(2)criteria. This was a randomised, non-blinded clinical trial conducted in a n...
| Autores: | , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2020 |
| País: | España |
| Institución: | Fundació Sant Joan de Déu |
| Repositorio: | r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu |
| OAI Identifier: | oai:fsjd.fundanetsuite.com:p19509 |
| Acceso en línea: | https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19509 |
| Access Level: | acceso abierto |
| Palabra clave: | Lung ultrasound Respiratory distress syndrome Premature newborns Surfactant |
| Sumario: | This study aimed to investigate whether using lung ultrasound (LUS) scores in premature newborns with respiratory distress syndrome (RDS) allows for earlier surfactant therapy (within the first 3 h of life) than using FiO(2)criteria. This was a randomised, non-blinded clinical trial conducted in a neonatal intensive care unit. The inclusion criteria were newborns with a gestational age of <= 32 weeks and RDS. Patients meeting the inclusion criteria were randomly assigned to two groups: the ultrasound group, administered surfactant based on LUS score and/or FiO(2)threshold, and the control group, guided by FiO(2)only. Fifty-six patients were included. The ultrasound group received surfactant earlier (1 h of life vs. 6 h,p< 0.001), with lower FiO(2)(25% vs. 30%,p= 0.016) and lower CO2(48 vs. 54,p= 0.011). After surfactant treatment, newborns in the ultrasound group presented a greater SpO(2)(p= 0.001) and SpO(2)/FiO(2)ratio (p= 0.012). Conclusions: LUS score allowed an earlier surfactant therapy, reduced oxygen exposure early in life and a better oxygenation after the treatment. This early surfactant replacement may lead to reduced oxygen exposure.What is Known:center dot Lung ultrasound scores predict the need for surfactant therapy in premature newborns.What is New:center dot This study shows that using lung ultrasound scores improves the timeliness of surfactant replacement compared with using FiO(2)alone. |
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