HoF3 and DyF3 nanoparticles as contrast agents for high-field magnetic resonance imaging

Clinical contrast agents (CAs) currently used in magnetic resonance imaging (MRI) at low fields are less effective at high magnetic fields. The development of new CAs is mandatory to improve diagnostic capabilities of the new generation of high field MRI scanners. The purpose of this study is to syn...

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Authors: González-Mancebo, Daniel, Becerro, Ana Isabel, Rojas, T. Cristina, García-Martín, María L., Fuente, Jesús M. de la, Ocaña, Manuel
Format: article
Status:Versión aceptada para publicación
Publication Date:2017
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/159239
Online Access:http://hdl.handle.net/10261/159239
Access Level:Open access
Keyword:Dysprosium fluoride
Relaxivity
Contrast agent
MRI
Holmium fluoride
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spelling HoF3 and DyF3 nanoparticles as contrast agents for high-field magnetic resonance imagingGonzález-Mancebo, DanielBecerro, Ana IsabelRojas, T. CristinaGarcía-Martín, María L.Fuente, Jesús M. de laOcaña, ManuelDysprosium fluorideRelaxivityContrast agentMRIHolmium fluorideClinical contrast agents (CAs) currently used in magnetic resonance imaging (MRI) at low fields are less effective at high magnetic fields. The development of new CAs is mandatory to improve diagnostic capabilities of the new generation of high field MRI scanners. The purpose of this study is to synthesize uniform, water dispersible LnF3 (Ln = Ho, Dy) nanoparticles (NPs) and to evaluate their relaxivity at high magnetic field (9.4 T) as a function of size and composition. Two different types of HoF3 NPs are obtained by homogeneous precipitation in ethylene glycol at 120 °C. The use of holmium acetate as holmium precursor leads to rhombus-like nanoparticles, while smaller, ellipsoid-like nanoparticles are obtained when nitrate is used as the holmium salt. To explain this behavior, the mechanism of formation of both kinds of particles is analyzed in detail. Likewise, rhombus-like DyF3 nanoparticles are prepared following the same method as for the rhombus-like HoF3 nanoparticles. We have found, to the best of knowledge, the highest transverse relaxivity values at 9.4 T described in the literature for this kind of CAs. Finally, the LnF3 NPs have shown negligible cytotoxicity for C6 rat glioma cells for concentrations up to 0.1 mg mL¿1.This work was supported by the Spanish Ministry of Economy and competitiveness (MINECO) (MAT2014‐54852‐R and SAF2014‐54763‐C2‐2‐R), the CSIC (PIE 201560E056 and PIE 201460E005), the Fondo Social Europeo (FSE; Gobierno de Aragón) and the CIBER‐BBN.Peer ReviewedJohn Wiley & SonsMinisterio de Economía y Competitividad (España)Consejo Superior de Investigaciones Científicas (España)European CommissionGobierno de AragónConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2018201820172018info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/159239reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/MAT2014‐54852‐Rinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2014‐54763‐C2‐2‐Rhttps://doi.org/10.1002/ppsc.201700116Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1592392026-05-22T06:33:51Z
dc.title.none.fl_str_mv HoF3 and DyF3 nanoparticles as contrast agents for high-field magnetic resonance imaging
title HoF3 and DyF3 nanoparticles as contrast agents for high-field magnetic resonance imaging
spellingShingle HoF3 and DyF3 nanoparticles as contrast agents for high-field magnetic resonance imaging
González-Mancebo, Daniel
Dysprosium fluoride
Relaxivity
Contrast agent
MRI
Holmium fluoride
title_short HoF3 and DyF3 nanoparticles as contrast agents for high-field magnetic resonance imaging
title_full HoF3 and DyF3 nanoparticles as contrast agents for high-field magnetic resonance imaging
title_fullStr HoF3 and DyF3 nanoparticles as contrast agents for high-field magnetic resonance imaging
title_full_unstemmed HoF3 and DyF3 nanoparticles as contrast agents for high-field magnetic resonance imaging
title_sort HoF3 and DyF3 nanoparticles as contrast agents for high-field magnetic resonance imaging
dc.creator.none.fl_str_mv González-Mancebo, Daniel
Becerro, Ana Isabel
Rojas, T. Cristina
García-Martín, María L.
Fuente, Jesús M. de la
Ocaña, Manuel
author González-Mancebo, Daniel
author_facet González-Mancebo, Daniel
Becerro, Ana Isabel
Rojas, T. Cristina
García-Martín, María L.
Fuente, Jesús M. de la
Ocaña, Manuel
author_role author
author2 Becerro, Ana Isabel
Rojas, T. Cristina
García-Martín, María L.
Fuente, Jesús M. de la
Ocaña, Manuel
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Consejo Superior de Investigaciones Científicas (España)
European Commission
Gobierno de Aragón
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Dysprosium fluoride
Relaxivity
Contrast agent
MRI
Holmium fluoride
topic Dysprosium fluoride
Relaxivity
Contrast agent
MRI
Holmium fluoride
description Clinical contrast agents (CAs) currently used in magnetic resonance imaging (MRI) at low fields are less effective at high magnetic fields. The development of new CAs is mandatory to improve diagnostic capabilities of the new generation of high field MRI scanners. The purpose of this study is to synthesize uniform, water dispersible LnF3 (Ln = Ho, Dy) nanoparticles (NPs) and to evaluate their relaxivity at high magnetic field (9.4 T) as a function of size and composition. Two different types of HoF3 NPs are obtained by homogeneous precipitation in ethylene glycol at 120 °C. The use of holmium acetate as holmium precursor leads to rhombus-like nanoparticles, while smaller, ellipsoid-like nanoparticles are obtained when nitrate is used as the holmium salt. To explain this behavior, the mechanism of formation of both kinds of particles is analyzed in detail. Likewise, rhombus-like DyF3 nanoparticles are prepared following the same method as for the rhombus-like HoF3 nanoparticles. We have found, to the best of knowledge, the highest transverse relaxivity values at 9.4 T described in the literature for this kind of CAs. Finally, the LnF3 NPs have shown negligible cytotoxicity for C6 rat glioma cells for concentrations up to 0.1 mg mL¿1.
publishDate 2017
dc.date.none.fl_str_mv 2017
2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/159239
url http://hdl.handle.net/10261/159239
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/MAT2014‐54852‐R
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2014‐54763‐C2‐2‐R
https://doi.org/10.1002/ppsc.201700116
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv John Wiley & Sons
publisher.none.fl_str_mv John Wiley & Sons
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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