Dataset - Sodium lanthanide tungstate-based nanoparticles as bimodal contrast agents for in vivo high-field MRI and CT imaging
Research on High-Field Magnetic Resonance Imaging (HF-MRI) has increased in recent years, aiming to improve diagnosis accuracy by increasing the signal-to-noise ratio and hence image quality. Conventional contrast agents (CAs) have important limitations for HF-MRI, with the consequent need for the d...
| Autores: | , , , , , , |
|---|---|
| Tipo de recurso: | conjunto de datos |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/366276 |
| Acceso en línea: | http://hdl.handle.net/10261/366276 https://doi.org/10.20350/digitalCSIC/16522 |
| Access Level: | acceso abierto |
| Palabra clave: | Bimodal EPR effect Sodium dysprosium tungstate Sodium holmium tungstate Computed tomography imaging High-field magnetic resonance imaging Contrast agents |
| Sumario: | Research on High-Field Magnetic Resonance Imaging (HF-MRI) has increased in recent years, aiming to improve diagnosis accuracy by increasing the signal-to-noise ratio and hence image quality. Conventional contrast agents (CAs) have important limitations for HF-MRI, with the consequent need for the development of new CAs. Among the most promising alternatives are those based on Dy3+ or Ho3+ compounds. Notably, the high atomic number of lanthanide cations would bestow a high capability for X-ray attenuation to such Dy or Ho-based compounds, which would allow them to be also employed as CAs for X-ray computed tomography (CT). In this work, we have prepared uniform NaDy(WO4)2 and NaHo(WO4)2 nanoparticles NPs, which were dispersible under conditions that mimic the physiological media and were nontoxic for cells, meeting the main requirements for their use in vivo. Both NPs exhibited satisfactory magnetic relaxivities at 9.4T, thus making them a promising alternative to clinical CAs for HF-MRI. Furthermore, after their intravenous administration in tumor-bearing mice, both NPs exhibited significant accumulation inside the tumor at 24 h, attributable to passive targeting by the Enhanced Permeability and Retention (EPR) effect. Therefore, our NPs are suitable for detection of tumors through HF-MRI. Finally, NaDy(WO4)2 NPs showed a superior X-ray attenuation capability than iohexol (commercial CT CA), which, along with their high r2 value, makes them suitable as dual-probe for dual HF-MRI and CT imaging, as demonstrated by in vivo experiments conducted using healthy mice. |
|---|