Dysprosium and holmium vanadate nanoprobes as high-performance contrast agents for high-field magnetic resonance and computed tomography imaging
A wet chemical method for the synthesis of uniform and well-dispersed dysprosium vanadate (DyVO4) and holmium vanadate (HoVO4) nanoparticles with almost spherical shape and a mean size of ⁓ 60 nm and their functionalization with polyacrylic acid is described. The transverse magnetic relaxivity of bo...
| Autores: | , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/229433 |
| Acceso en línea: | http://hdl.handle.net/10261/229433 |
| Access Level: | acceso abierto |
| Palabra clave: | Holmium vanadate Dysprosium vanadate Poliol Nanoparticles High field MRI Computed tomography |
| Sumario: | A wet chemical method for the synthesis of uniform and well-dispersed dysprosium vanadate (DyVO4) and holmium vanadate (HoVO4) nanoparticles with almost spherical shape and a mean size of ⁓ 60 nm and their functionalization with polyacrylic acid is described. The transverse magnetic relaxivity of both systems at 9.4 T is analyzed on the basis of magnetic susceptibility and magnetization measurements in order to evaluate their potential for applications as high field MRI contrast agent. In addition, the X-ray attenuation properties of these systems are also studied to determine their capability as computed tomography contrast agent. Finally, the colloidal stability under physiological pH conditions and the cytotoxicity of the functionalized NPs is also addressed to assess their suitability for bioimaging applications |
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