Update of the risk assessment of mineral oil hydrocarbons in food
143 p.-21 fig.- 41 tab.
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de documento: | artigo |
| Estado: | Versão publicada |
| Data de publicação: | 2023 |
| País: | España |
| Recursos: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositório: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/335541 |
| Acesso em linha: | http://hdl.handle.net/10261/335541 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Mineral oil hydrocarbons (MOH) MOSH MOAH Alkanes Aromatic hydrocarbons Human dietary exposure Toxicity |
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Update of the risk assessment of mineral oil hydrocarbons in foodEFSA CONTAM PanelSchrenk, DieterBignami, MargheritaBodin, LaurentDel Mazo, JesúsGrasl-Kraupp, BettinaHogstrand, ChristerHoogenboom, Laurentius (Ron)Leblanc, Jean-CharlesNebbia, Carlo StefanoNielsen, ElsaNtzani, EvangeliaPetersen, AnnetteSand, SalomonSchwerdtle, TanjaVleminckx, ChristianeWallace, HeatherAlexander, JanGoldbeck, ChristopheGrob, KonradGómez-Ruiz, José ÁngelMosbach-Schulz, OlafBinaglia, MarcoChipman, James KevinMineral oil hydrocarbons (MOH)MOSHMOAHAlkanesAromatic hydrocarbonsHuman dietary exposureToxicity143 p.-21 fig.- 41 tab.Mineral oil hydrocarbons (MOH) are composed of saturated hydrocarbons (MOSH) and aromatic hydrocarbons (MOAH). Due to the complexity of the MOH composition, their complete chemical characterisation is not possible. MOSH accumulation is observed in various tissues, with species-specific differences. Formation of liver epithelioid lipogranulomas and inflammation, as well as increased liver and spleen weights, are observed in Fischer 344 (F344) rats, but not in Sprague–Dawley (SD) rats. These effects are related to specific accumulation of wax components in the liver of F344 rats, which is not observed in SD rats or humans. The CONTAM Panel concluded that F344 rats are not an appropriate model for effects of MOSH with wax components. A NOAEL of 236 mg/kg body weight (bw) per day, corresponding to the highest tested dose in F344 rats of a white mineral oil product virtually free of wax components, was selected as relevant reference point (RP). The highest dietary exposure to MOSH was estimated for the young population, with lower bound–upper bound (LB–UB) means and 95th percentiles of 0.085–0.126 and 0.157–0.212 mg/kg bw per day, respectively.Considering a margin of exposure approach, the Panel concluded that the present dietary exposure to MOSH does not raise concern for human health for all age classes. Genotoxicity and carcinogenicity are associated with MOAH with three or more aromatic rings. For this subfraction, a surrogate RP of 0.49 mg/kg bw per day, calculated from data on eight polycyclic aromatic hydrocarbons, was considered. The highest dietary exposure to MOAH was also in the young population, with LB–UB mean and 95th percentile estimations of 0.003–0.031 and 0.011–0.059 mg/kg bw per day,respectively. Based on two scenarios on three or more ring MOAH contents in the diet and lacking toxicological information on effects of 1 and 2 ring MOAH, a possible concern for human health was raised.Peer reviewedWiley-VCHEuropean Food Safety AuthoritySchrenk, Dieter [0000-0002-7717-5533]Bignami, Margherita [0000-0002-1525-6864]Bodin, Laurent [0000-0001-5671-3139]Del Mazo, Jesús [0000-0003-3269-3895]Grasl-Kraupp, Bettina [0000-0003-4889-6531]Hogstrand, Christer [0000-0001-7545-6975]Hoogenboom, Laurentius (Ron) [0000-0002-8913-5328]Leblanc, Jean-Charles [0000-0003-2872-3414]Nielsen, Elsa [0000-0002-6874-2575]Ntzani, Evangelia [0000-0003-3712-4181]Petersen, Annette [0000-0003-3996-2701]Sand, Salomon [0000-0002-3360-0534]Schwerdtle, Tanja [0000-0002-4873-7488]Vleminckx, Christiane [0000-0002-9928-1601]Goldbeck, Christophe [0000-0003-1539-464X]Gómez-Ruiz, José Ángel [0000-0001-9386-6185]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202320232023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/335541reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.2903/j.efsa.2023.8215Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3355412026-05-22T06:33:51Z |
| dc.title.none.fl_str_mv |
Update of the risk assessment of mineral oil hydrocarbons in food |
| title |
Update of the risk assessment of mineral oil hydrocarbons in food |
| spellingShingle |
Update of the risk assessment of mineral oil hydrocarbons in food EFSA CONTAM Panel Mineral oil hydrocarbons (MOH) MOSH MOAH Alkanes Aromatic hydrocarbons Human dietary exposure Toxicity |
| title_short |
Update of the risk assessment of mineral oil hydrocarbons in food |
| title_full |
Update of the risk assessment of mineral oil hydrocarbons in food |
| title_fullStr |
Update of the risk assessment of mineral oil hydrocarbons in food |
| title_full_unstemmed |
Update of the risk assessment of mineral oil hydrocarbons in food |
| title_sort |
Update of the risk assessment of mineral oil hydrocarbons in food |
| dc.creator.none.fl_str_mv |
EFSA CONTAM Panel Schrenk, Dieter Bignami, Margherita Bodin, Laurent Del Mazo, Jesús Grasl-Kraupp, Bettina Hogstrand, Christer Hoogenboom, Laurentius (Ron) Leblanc, Jean-Charles Nebbia, Carlo Stefano Nielsen, Elsa Ntzani, Evangelia Petersen, Annette Sand, Salomon Schwerdtle, Tanja Vleminckx, Christiane Wallace, Heather Alexander, Jan Goldbeck, Christophe Grob, Konrad Gómez-Ruiz, José Ángel Mosbach-Schulz, Olaf Binaglia, Marco Chipman, James Kevin |
| author |
EFSA CONTAM Panel |
| author_facet |
EFSA CONTAM Panel Schrenk, Dieter Bignami, Margherita Bodin, Laurent Del Mazo, Jesús Grasl-Kraupp, Bettina Hogstrand, Christer Hoogenboom, Laurentius (Ron) Leblanc, Jean-Charles Nebbia, Carlo Stefano Nielsen, Elsa Ntzani, Evangelia Petersen, Annette Sand, Salomon Schwerdtle, Tanja Vleminckx, Christiane Wallace, Heather Alexander, Jan Goldbeck, Christophe Grob, Konrad Gómez-Ruiz, José Ángel Mosbach-Schulz, Olaf Binaglia, Marco Chipman, James Kevin |
| author_role |
author |
| author2 |
Schrenk, Dieter Bignami, Margherita Bodin, Laurent Del Mazo, Jesús Grasl-Kraupp, Bettina Hogstrand, Christer Hoogenboom, Laurentius (Ron) Leblanc, Jean-Charles Nebbia, Carlo Stefano Nielsen, Elsa Ntzani, Evangelia Petersen, Annette Sand, Salomon Schwerdtle, Tanja Vleminckx, Christiane Wallace, Heather Alexander, Jan Goldbeck, Christophe Grob, Konrad Gómez-Ruiz, José Ángel Mosbach-Schulz, Olaf Binaglia, Marco Chipman, James Kevin |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
European Food Safety Authority Schrenk, Dieter [0000-0002-7717-5533] Bignami, Margherita [0000-0002-1525-6864] Bodin, Laurent [0000-0001-5671-3139] Del Mazo, Jesús [0000-0003-3269-3895] Grasl-Kraupp, Bettina [0000-0003-4889-6531] Hogstrand, Christer [0000-0001-7545-6975] Hoogenboom, Laurentius (Ron) [0000-0002-8913-5328] Leblanc, Jean-Charles [0000-0003-2872-3414] Nielsen, Elsa [0000-0002-6874-2575] Ntzani, Evangelia [0000-0003-3712-4181] Petersen, Annette [0000-0003-3996-2701] Sand, Salomon [0000-0002-3360-0534] Schwerdtle, Tanja [0000-0002-4873-7488] Vleminckx, Christiane [0000-0002-9928-1601] Goldbeck, Christophe [0000-0003-1539-464X] Gómez-Ruiz, José Ángel [0000-0001-9386-6185] Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72] |
| dc.subject.none.fl_str_mv |
Mineral oil hydrocarbons (MOH) MOSH MOAH Alkanes Aromatic hydrocarbons Human dietary exposure Toxicity |
| topic |
Mineral oil hydrocarbons (MOH) MOSH MOAH Alkanes Aromatic hydrocarbons Human dietary exposure Toxicity |
| description |
143 p.-21 fig.- 41 tab. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023 2023 2023 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_6501 Publisher's version info:eu-repo/semantics/publishedVersion |
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article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10261/335541 |
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http://hdl.handle.net/10261/335541 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
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https://doi.org/10.2903/j.efsa.2023.8215 Sí |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Wiley-VCH |
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Wiley-VCH |
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reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC instname:Consejo Superior de Investigaciones Científicas (CSIC) |
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Consejo Superior de Investigaciones Científicas (CSIC) |
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DIGITAL.CSIC. Repositorio Institucional del CSIC |
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DIGITAL.CSIC. Repositorio Institucional del CSIC |
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