Association of adiposity and its changes over time with COVID-19 risk in older adults with overweight/obesity and metabolic syndrome: a longitudinal evaluation in the PREDIMED-Plus cohort

Background Cross-sectionally, older age and obesity are associated with increased coronavirus disease-2019 (COVID-19) risk. We assessed the longitudinal associations of baseline and changes in adiposity parameters with COVID-19 incidence in older adults at high cardiovascular risk.Methods This analy...

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Autores: Shyam, S, Garcia-Gavilan, JF, Paz-Graniel, I, Gaforio, JJ, Martinez-Gonzalez, MA, Corella, D, Martinez, JA, Alonso-Gomez, AM, Waernberg, J, Vioque, J, Romaguera, D, Lopez-Miranda, J, Estruch, R, Tinahones, FJ, Lapetra, J, Serra-Majem, JL, Bueno-Cavanillas, A, Tur, JA, Sanchez, VM, Pinto, X, Matia-Martin, P, Vidal, J, Vazquez, C, Daimiel, L, Ros, E, Fernandez-Aranda, F, Nishi, SK, Garcia-Regata, O, Toledo, E, Asensio, EM, Castaner, O, Garcia-Rios, A, Torres-Collado, L, Gomez-Gracia, E, Zulet, MA, Ruiz, NG, Casas, R, Cano-Ibanez, N, Tojal-Sierra, L, Gomez-Perez, AM, Sorli, JV, Cinza-Sanjurjo, S, Martin-Pelaez, S, Pena-Orihuela, PJ, Oncina-Canovas, A, Perez-Araluce, R, Zomeno, MD, Chaplin, A, Delgado-Rodriguez, M, Babio, N, Fito, M, Salas-Salvado, J
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
Repositorio:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
OAI Identifier:oai:isabial.fundanetsuite.com:p9902
Acceso en línea:https://isabial.portalinvestigacion.com/publicaciones9902
https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-023-03079-z
Access Level:acceso abierto
Palabra clave:Obesity
COVID-19
Older adults
Weight loss
Central obesity
Descripción
Sumario:Background Cross-sectionally, older age and obesity are associated with increased coronavirus disease-2019 (COVID-19) risk. We assessed the longitudinal associations of baseline and changes in adiposity parameters with COVID-19 incidence in older adults at high cardiovascular risk.Methods This analysis included 6874 men and women (aged 55-75 years) with overweight/obesity and metabolic syndrome in the PREDIMED-Plus lifestyle intervention trial for cardiovascular risk reduction. Body weight, body-mass-index (BMI), waist circumference, waist-to-height ratio (WHtR), and a body shape index (ABSI) were measured at baseline and annual follow-up visits. COVID-19 was ascertained by an independent Event Committee until 31 December 2021. Cox regression models were fitted to evaluate the risk of COVID-19 incidence based on baseline adiposity parameters measured 5-6 years before the pandemic and their changes at the visit prior to censoring.Results At the time of censoring, 653 incident COVID-19 cases occurred. Higher baseline body weight, BMI, waist circumference, and WHtR were associated with increased COVID-19 risk. During the follow-up, every unit increase in body weight (HRadj (95%CI): 1.01 (1.00, 1.03)) and BMI (HRadj: 1.04 (1.003, 1.08)) was associated with increased COVID-19 risk.Conclusions In older adults with overweight/obesity, clinically significant weight loss may protect against COVID-19.

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