Association of adiposity and its changes over time with COVID-19 risk in older adults with overweight/obesity and metabolic syndrome: a longitudinal evaluation in the PREDIMED-Plus cohort

Background: Cross-sectionally, older age and obesity are associated with increased coronavirus disease-2019 (COVID-19) risk. We assessed the longitudinal associations of baseline and changes in adiposity parameters with COVID-19 incidence in older adults at high cardiovascular risk. Methods: This an...

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Autores: Shyam, S., García-Gavilán, J.F., Paz-Graniel, I., Gaforio, J.J., Martínez-González, M.Á., Corella, D., Martínez, J.A., Alonso-Gómez, Á.M., Wärnberg, J., Vioque, J., Romaguera, D., López-Miranda, J., Estruch, R., Tinahones, F.J., Lapetra, J., Serra-Majem, J.L., Bueno-Cavanillas, A., Tur, J.A., Sánchez, V.M., Pintó, X., Matía-Martín, P., Vidal, J., Vázquez, C., Daimiel, L., Ros, E., Fernandez-Aranda, F., Nishi, S.K., Garcia-Regata, O., Toledo, E., Asensio, E.M., Castañer, O., Garcia-Rios, A., Torres-Collado, L., Gómez-Gracia, E., Zulet, M.A., Ruiz, N.G., Casas, R., Cano-Ibáñez, N., Tojal-Sierra, L., Gómez-Perez, A.M., Sorlí, J.V., Cinza Sanjurjo, Sergio, Martín-Peláez, S., Peña-Orihuela, P.J., Oncina-Canovas, A., Perez-Araluce, R., Zomeño, M.D., Chaplin, A., Delgado-Rodríguez, M., Babio, N., Fitó, M., Salas-Salvadó, J.
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Servizo Galego de Saúde (SERGAS)
Repositorio:RUNA. Repositorio da Consellería de Sanidade e Sergas
OAI Identifier:oai:runa.sergas.gal:20.500.11940/21118
Acceso en línea:https://portalcientifico.sergas.gal//documentos/6540bd3e2676d373b26fe12f
http://hdl.handle.net/20.500.11940/21118
Access Level:acceso abierto
Palabra clave:Aged
Female
Humans
Male
Adiposity
Body Mass Index
Body Weight
COVID-19
Metabolic Syndrome
Obesity
Overweight
Risk Factors
Waist Circumference
Middle Aged
AS Santiago
AS Santiago AP
Descripción
Sumario:Background: Cross-sectionally, older age and obesity are associated with increased coronavirus disease-2019 (COVID-19) risk. We assessed the longitudinal associations of baseline and changes in adiposity parameters with COVID-19 incidence in older adults at high cardiovascular risk. Methods: This analysis included 6874 men and women (aged 55-75 years) with overweight/obesity and metabolic syndrome in the PREDIMED-Plus lifestyle intervention trial for cardiovascular risk reduction. Body weight, body-mass-index (BMI), waist circumference, waist-to-height ratio (WHtR), and a body shape index (ABSI) were measured at baseline and annual follow-up visits. COVID-19 was ascertained by an independent Event Committee until 31 December 2021. Cox regression models were fitted to evaluate the risk of COVID-19 incidence based on baseline adiposity parameters measured 5-6 years before the pandemic and their changes at the visit prior to censoring. Results: At the time of censoring, 653 incident COVID-19 cases occurred. Higher baseline body weight, BMI, waist circumference, and WHtR were associated with increased COVID-19 risk. During the follow-up, every unit increase in body weight (HRadj (95%CI): 1.01 (1.00, 1.03)) and BMI (HRadj: 1.04 (1.003, 1.08)) was associated with increased COVID-19 risk. Conclusions: In older adults with overweight/obesity, clinically significant weight loss may protect against COVID-19. Trial registration: This study is registered at the International Standard Randomized Controlled Trial (ISRCT; http://www.isrctn.com/ISRCTN89898870).

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