Increased ex vivo cell death of central memory CD4 T cells in treated HIV infected individuals with unsatisfactory immune recovery

BACKGROUND: High levels of ex vivo CD4 T-cell death and the accumulation of highly differentiated and/or immunosenescent T cells have been associated with poor CD4 T-cell recovery in treated HIV-infected individuals. However, the relationship between cell death and T-cell differentiation is still un...

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Detalhes bibliográficos
Autores: Massanella Luna, Marta, 1983-, Gomez, Elisabet|||0000-0002-9779-5940, Carrillo, Jorge|||0000-0003-0221-5948, Curriu Martí, Marta, Ouchi, Dan|||0000-0002-8630-152X, Puig, Jordi|||0000-0002-4075-0346, Negredo Puigmal, Eugènia|||0000-0001-5298-1734, Cabrera Navarro, Cecilia|||0000-0002-9941-6828, Clotet Sala, Bonaventura|||0000-0003-3232-4598, Blanco, Julià|||0000-0002-2225-0217
Formato: artículo
Fecha de publicación:2015
País:España
Recursos:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:163153
Acesso em linha:https://ddd.uab.cat/record/163153
https://dx.doi.org/urn:doi:10.1186/s12967-015-0601-2
Access Level:acceso abierto
Palavra-chave:Immunodiscordant
Cell death
T-cell subsets
Immunosenescence
HAART
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Descrição
Resumo:BACKGROUND: High levels of ex vivo CD4 T-cell death and the accumulation of highly differentiated and/or immunosenescent T cells have been associated with poor CD4 T-cell recovery in treated HIV-infected individuals. However, the relationship between cell death and T-cell differentiation is still unclear. METHODS: We have analyzed cell death, immunosenescence and differentiation parameters in HAART-treated subjects (VL <50 copies/mL for more than 2 years) with CD4 T-cell count <350 cells/μL (immunodiscordant, n = 23) or.

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