A Lower Baseline CD4/CD8 T-Cell Ratio Is Independently Associated with Immunodiscordant Response to Antiretroviral Therapy in HIV-Infected Subjects

We explored if baseline CD4/CD8 T-cell ratio is associated with immunodiscordant response to antiretroviral therapy in HIV-infected subjects. Comparing immunodiscordant and immunoconcordant subjects matched by pretreatment CD4 counts, we observed a lower pretreatment CD4/CD8 T-cell ratio in immunodi...

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Bibliographic Details
Authors: Rosado-Sánchez, Isaac, Herrero-Fernández, Inés, Álvarez-Ríos, Ana Isabel, Genebat, Miguel, Abad Carrillo, M. A., Ruiz-Mateos, Ezequiel, Pulido, Federico, González-García, Juan, Montero, M., Bernal-Morell, Enrique, Vidal, Francesc, Leal, Manuel, Pacheco, Yolanda M.
Format: article
Status:Versión aceptada para publicación
Publication Date:2017
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/182745
Online Access:http://hdl.handle.net/10261/182745
Access Level:Open access
Keyword:CD4/CD8 T-cell ratio
Delayed cART
Low CD4 recovery
T-cell turnover
Thymic function
CD4/CD8 ratio
Antiretroviral therapy
Human immunodeficiency virus
Immunodiscordant
Description
Summary:We explored if baseline CD4/CD8 T-cell ratio is associated with immunodiscordant response to antiretroviral therapy in HIV-infected subjects. Comparing immunodiscordant and immunoconcordant subjects matched by pretreatment CD4 counts, we observed a lower pretreatment CD4/CD8 T-cell ratio in immunodiscordant subjects. Furthermore, pretreatment CD4/CD8 T-cell ratio, but not CD4 counts, correlated with the main immunological alterations observed in immunodiscordants, including increased regulatory T-cell (Treg) frequency and T-cell turnover-related markers. Then, in a larger cohort, only baseline CD4/CD8 T-cell ratio was independently associated with immunodiscordance, after adjusting by the viral CXCR4-tropic HIV variants. Our results suggest that the CD4/CD8 T-cell ratio could be an accurate biomarker of the subjacent immunological damage triggering immunodiscordance.

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