Dietary vitamin D and gastric cancer risk within the stomach cancer pooling (stop) project

Purpose: The evidence regarding the role of vitamin D on gastric cancer (GC) is controversial. Within the Stomach cancer Pooling (StoP) Project, a global consortium of epidemiological studies on GC, we aimed to evaluate the relationship between dietary vitamin D and GC risk. Methods: Five case-contr...

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Autores: Santucci, Claudia, Natale, Arianna, Pelucchi, Claudio, Bonzi, Rossella, Lunet, Nuno, Morais, Samantha, Vioque, Jesus, González-Palacios, Sandra, Castaño Vinyals, Gemma, Malekzadeh, Reza, Pakseresht, Mohammadreza, Negri, Eva, Boffetta, Paolo, Camargo, M. Constanza, Curado, Maria Paula, Zhang, Zuo-Feng, Boccia, Stefania, La Vecchia, Carlo, Rossi, Marta
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Recursos:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:dnet:rdupf_______::c15827e6ebdfe6150fdf75b95e760aba
Acesso em linha:https://hdl.handle.net/10230/73441
http://dx.doi.org/10.1007/s00394-025-03768-w
Access Level:acceso abierto
Palavra-chave:Dietary vitamin D
Epidemiology
Gastric cancer
Pooled analysis
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spelling Dietary vitamin D and gastric cancer risk within the stomach cancer pooling (stop) projectSantucci, ClaudiaNatale, AriannaPelucchi, ClaudioBonzi, RossellaLunet, NunoMorais, SamanthaVioque, JesusGonzález-Palacios, SandraCastaño Vinyals, GemmaMalekzadeh, RezaPakseresht, MohammadrezaNegri, EvaBoffetta, PaoloCamargo, M. ConstanzaCurado, Maria PaulaZhang, Zuo-FengBoccia, StefaniaLa Vecchia, CarloRossi, MartaDietary vitamin DEpidemiologyGastric cancerPooled analysisPurpose: The evidence regarding the role of vitamin D on gastric cancer (GC) is controversial. Within the Stomach cancer Pooling (StoP) Project, a global consortium of epidemiological studies on GC, we aimed to evaluate the relationship between dietary vitamin D and GC risk. Methods: Five case-control studies were included in the analysis, accounting for 1875 cases and 5899 controls. Odds ratios (OR) of GC and the corresponding 95% confidence intervals (CI) for tertiles of vitamin D intake were computed using logistic regression models adjusted for relevant confounders, including energy intake. The pooled ORs were computed using random-effect models. Results: The pooled OR of GC for the highest compared to the lowest tertile of vitamin D intake was 1.06 (95% CI 0.80-1.39), with a p for heterogeneity of 0.019. No significant association was found across strata of sex, age, socioeconomic status, smoking status, alcohol intake, and vegetable and fruit consumption. Conclusions: Our pooled analysis indicates that there is no association between dietary vitamin D and the risk of GC.Springer2026202620252026info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/10230/73441http://dx.doi.org/10.1007/s00394-025-03768-wreponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésEuropean Journal of Nutrition. 2025;64(6):269© The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:dnet:rdupf_______::c15827e6ebdfe6150fdf75b95e760aba2026-06-12T07:21:37Z
dc.title.none.fl_str_mv Dietary vitamin D and gastric cancer risk within the stomach cancer pooling (stop) project
title Dietary vitamin D and gastric cancer risk within the stomach cancer pooling (stop) project
spellingShingle Dietary vitamin D and gastric cancer risk within the stomach cancer pooling (stop) project
Santucci, Claudia
Dietary vitamin D
Epidemiology
Gastric cancer
Pooled analysis
title_short Dietary vitamin D and gastric cancer risk within the stomach cancer pooling (stop) project
title_full Dietary vitamin D and gastric cancer risk within the stomach cancer pooling (stop) project
title_fullStr Dietary vitamin D and gastric cancer risk within the stomach cancer pooling (stop) project
title_full_unstemmed Dietary vitamin D and gastric cancer risk within the stomach cancer pooling (stop) project
title_sort Dietary vitamin D and gastric cancer risk within the stomach cancer pooling (stop) project
dc.creator.none.fl_str_mv Santucci, Claudia
Natale, Arianna
Pelucchi, Claudio
Bonzi, Rossella
Lunet, Nuno
Morais, Samantha
Vioque, Jesus
González-Palacios, Sandra
Castaño Vinyals, Gemma
Malekzadeh, Reza
Pakseresht, Mohammadreza
Negri, Eva
Boffetta, Paolo
Camargo, M. Constanza
Curado, Maria Paula
Zhang, Zuo-Feng
Boccia, Stefania
La Vecchia, Carlo
Rossi, Marta
author Santucci, Claudia
author_facet Santucci, Claudia
Natale, Arianna
Pelucchi, Claudio
Bonzi, Rossella
Lunet, Nuno
Morais, Samantha
Vioque, Jesus
González-Palacios, Sandra
Castaño Vinyals, Gemma
Malekzadeh, Reza
Pakseresht, Mohammadreza
Negri, Eva
Boffetta, Paolo
Camargo, M. Constanza
Curado, Maria Paula
Zhang, Zuo-Feng
Boccia, Stefania
La Vecchia, Carlo
Rossi, Marta
author_role author
author2 Natale, Arianna
Pelucchi, Claudio
Bonzi, Rossella
Lunet, Nuno
Morais, Samantha
Vioque, Jesus
González-Palacios, Sandra
Castaño Vinyals, Gemma
Malekzadeh, Reza
Pakseresht, Mohammadreza
Negri, Eva
Boffetta, Paolo
Camargo, M. Constanza
Curado, Maria Paula
Zhang, Zuo-Feng
Boccia, Stefania
La Vecchia, Carlo
Rossi, Marta
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Dietary vitamin D
Epidemiology
Gastric cancer
Pooled analysis
topic Dietary vitamin D
Epidemiology
Gastric cancer
Pooled analysis
description Purpose: The evidence regarding the role of vitamin D on gastric cancer (GC) is controversial. Within the Stomach cancer Pooling (StoP) Project, a global consortium of epidemiological studies on GC, we aimed to evaluate the relationship between dietary vitamin D and GC risk. Methods: Five case-control studies were included in the analysis, accounting for 1875 cases and 5899 controls. Odds ratios (OR) of GC and the corresponding 95% confidence intervals (CI) for tertiles of vitamin D intake were computed using logistic regression models adjusted for relevant confounders, including energy intake. The pooled ORs were computed using random-effect models. Results: The pooled OR of GC for the highest compared to the lowest tertile of vitamin D intake was 1.06 (95% CI 0.80-1.39), with a p for heterogeneity of 0.019. No significant association was found across strata of sex, age, socioeconomic status, smoking status, alcohol intake, and vegetable and fruit consumption. Conclusions: Our pooled analysis indicates that there is no association between dietary vitamin D and the risk of GC.
publishDate 2025
dc.date.none.fl_str_mv 2025
2026
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/10230/73441
http://dx.doi.org/10.1007/s00394-025-03768-w
url https://hdl.handle.net/10230/73441
http://dx.doi.org/10.1007/s00394-025-03768-w
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv European Journal of Nutrition. 2025;64(6):269
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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