Dietary vitamin D and gastric cancer risk within the stomach cancer pooling (stop) project

Purpose: The evidence regarding the role of vitamin D on gastric cancer (GC) is controversial. Within the Stomach cancer Pooling (StoP) Project, a global consortium of epidemiological studies on GC, we aimed to evaluate the relationship between dietary vitamin D and GC risk. Methods: Five case-contr...

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Detalles Bibliográficos
Autores: Santucci, Claudia, Natale, Arianna, Pelucchi, Claudio, Bonzi, Rossella, Lunet, Nuno, Morais, Samantha, Vioque, Jesus, González-Palacios, Sandra, Castaño Vinyals, Gemma, Malekzadeh, Reza, Pakseresht, Mohammadreza, Negri, Eva, Boffetta, Paolo, Camargo, M. Constanza, Curado, Maria Paula, Zhang, Zuo-Feng, Boccia, Stefania, La Vecchia, Carlo, Rossi, Marta
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:dnet:rdupf_______::c15827e6ebdfe6150fdf75b95e760aba
Acceso en línea:https://hdl.handle.net/10230/73441
http://dx.doi.org/10.1007/s00394-025-03768-w
Access Level:acceso abierto
Palabra clave:Dietary vitamin D
Epidemiology
Gastric cancer
Pooled analysis
Descripción
Sumario:Purpose: The evidence regarding the role of vitamin D on gastric cancer (GC) is controversial. Within the Stomach cancer Pooling (StoP) Project, a global consortium of epidemiological studies on GC, we aimed to evaluate the relationship between dietary vitamin D and GC risk. Methods: Five case-control studies were included in the analysis, accounting for 1875 cases and 5899 controls. Odds ratios (OR) of GC and the corresponding 95% confidence intervals (CI) for tertiles of vitamin D intake were computed using logistic regression models adjusted for relevant confounders, including energy intake. The pooled ORs were computed using random-effect models. Results: The pooled OR of GC for the highest compared to the lowest tertile of vitamin D intake was 1.06 (95% CI 0.80-1.39), with a p for heterogeneity of 0.019. No significant association was found across strata of sex, age, socioeconomic status, smoking status, alcohol intake, and vegetable and fruit consumption. Conclusions: Our pooled analysis indicates that there is no association between dietary vitamin D and the risk of GC.

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