Dietary vitamin D and gastric cancer risk within the stomach cancer pooling (stop) project

PurposeThe evidence regarding the role of vitamin D on gastric cancer (GC) is controversial. Within the Stomach cancer Pooling (StoP) Project, a global consortium of epidemiological studies on GC, we aimed to evaluate the relationship between dietary vitamin D and GC risk.MethodsFive case-control st...

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Detalles Bibliográficos
Autores: Santucci, C, Natale, A, Pelucchi, C, Bonzi, R, Lunet, N, Morais, S, Vioque, J, González-Palacios, S, Aragonés, N, Castaño-Vinyals, G, Malekzadeh, R, Pakseresht, M, Negri, E, Boffetta, P, Camargo, MC, Curado, MP, Zhang, ZF, Boccia, S, La Vecchia, C, Rossi, M
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
Repositorio:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
OAI Identifier:oai:isabial.fundanetsuite.com:p11306
Acceso en línea:https://isabial.portalinvestigacion.com/publicaciones11306
https://doi.org/10.1007/s00394-025-03768-w
Access Level:acceso abierto
Palabra clave:Dietary vitamin D
Epidemiology
Gastric cancer
Pooled analysis
Descripción
Sumario:PurposeThe evidence regarding the role of vitamin D on gastric cancer (GC) is controversial. Within the Stomach cancer Pooling (StoP) Project, a global consortium of epidemiological studies on GC, we aimed to evaluate the relationship between dietary vitamin D and GC risk.MethodsFive case-control studies were included in the analysis, accounting for 1875 cases and 5899 controls. Odds ratios (OR) of GC and the corresponding 95% confidence intervals (CI) for tertiles of vitamin D intake were computed using logistic regression models adjusted for relevant confounders, including energy intake. The pooled ORs were computed using random-effect models.ResultsThe pooled OR of GC for the highest compared to the lowest tertile of vitamin D intake was 1.06 (95% CI 0.80-1.39), with a p for heterogeneity of 0.019. No significant association was found across strata of sex, age, socioeconomic status, smoking status, alcohol intake, and vegetable and fruit consumption.ConclusionsOur pooled analysis indicates that there is no association between dietary vitamin D and the risk of GC.

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