A simple score to predict early severe infections in patients with newly diagnosed multiple myeloma

Encinas, Cristina; Hernandez Rivas, José Ángel; Oriol, Albert; Rosiñol Dachs, Laura; Blanchard, María Jesús; Bellón, José María; García Sanz, Ramón; Rubia, Javier de la; López de la Guía, Ana; Jímenez Ubieto, Ana; Jarque, Isidro; Iñigo, Belén; Dourdil, Victoria; Arriba, Felipe de; Cuéllar Pérez-Ávila, Clara; Gonzalez, Yolanda; Hernández, Miguel Teodoro; Bargay, Joan; Granell, Miguel; Rodríguez Otero, Paula; Silvent, Maialen; Cabrera, Carmen; Rios, Rafael; Alegre, Adrián; Gironella, Mercedes; Gonzalez, Marta Sonia; Sureda, Anna; Sampol, Antonia; Ocio, Enrique M.; Krsnik, Isabel; García, Antonio; García Mateo, Aránzazu; Soler, Joan Alfons; Martín, Jesús; Arguiñano Pérez, José Mª; Mateos, María Victoria; Bladé, J. (Joan); San Miguel, Jesús F.; Lahuerta, Juan José; Martínez López, Joaquín; Gem/pethema (Grupo Español de Mieloma/Programa para el estudio de la terapéutica en hemopatías malignas) Cooperative Study Group

A simple score to predict early severe infections in patients with newly diagnosed multiple myeloma

Infections remain a common complication in patients with multiple myeloma (MM) and are associated with morbidity and mortality. A risk score to predict the probability of early severe infection could help to identify the patients that would benefit from preventive measures. We undertook a post hoc a...

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Autores:	Encinas, Cristina, Hernandez Rivas, José Ángel, Oriol, Albert, Rosiñol Dachs, Laura, Blanchard, María Jesús, Bellón, José María, García Sanz, Ramón, Rubia, Javier de la, López de la Guía, Ana, Jímenez Ubieto, Ana, Jarque, Isidro, Iñigo, Belén, Dourdil, Victoria, Arriba, Felipe de, Cuéllar Pérez-Ávila, Clara, Gonzalez, Yolanda, Hernández, Miguel Teodoro, Bargay, Joan, Granell, Miguel, Rodríguez Otero, Paula, Silvent, Maialen, Cabrera, Carmen, Rios, Rafael, Alegre, Adrián, Gironella, Mercedes, Gonzalez, Marta Sonia, Sureda, Anna, Sampol, Antonia, Ocio, Enrique M., Krsnik, Isabel, García, Antonio, García Mateo, Aránzazu, Soler, Joan Alfons, Martín, Jesús, Arguiñano Pérez, José Mª, Mateos, María Victoria, Bladé, J. (Joan), San Miguel, Jesús F., Lahuerta, Juan José, Martínez López, Joaquín, Gem/pethema (Grupo Español de Mieloma/Programa para el estudio de la terapéutica en hemopatías malignas) Cooperative Study Group
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2022
País:	España
Institución:	Universidad de Barcelona
Repositorio:	Dipòsit Digital de la UB
OAI Identifier:	oai:diposit.ub.edu:2445/185581
Acceso en línea:	https://hdl.handle.net/2445/185581
Access Level:	acceso abierto
Palabra clave:	Mieloma múltiple Antibiòtics Multiple myeloma Antibiotics

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spelling	A simple score to predict early severe infections in patients with newly diagnosed multiple myelomaEncinas, CristinaHernandez Rivas, José ÁngelOriol, AlbertRosiñol Dachs, LauraBlanchard, María JesúsBellón, José MaríaGarcía Sanz, RamónRubia, Javier de laLópez de la Guía, AnaJímenez Ubieto, AnaJarque, IsidroIñigo, BelénDourdil, VictoriaArriba, Felipe deCuéllar Pérez-Ávila, ClaraGonzalez, YolandaHernández, Miguel TeodoroBargay, JoanGranell, MiguelRodríguez Otero, PaulaSilvent, MaialenCabrera, CarmenRios, RafaelAlegre, AdriánGironella, MercedesGonzalez, Marta SoniaSureda, AnnaSampol, AntoniaOcio, Enrique M.Krsnik, IsabelGarcía, AntonioGarcía Mateo, AránzazuSoler, Joan AlfonsMartín, JesúsArguiñano Pérez, José MªMateos, María VictoriaBladé, J. (Joan)San Miguel, Jesús F.Lahuerta, Juan JoséMartínez López, JoaquínGem/pethema (Grupo Español de Mieloma/Programa para el estudio de la terapéutica en hemopatías malignas) Cooperative Study GroupMieloma múltipleAntibiòticsMultiple myelomaAntibioticsInfections remain a common complication in patients with multiple myeloma (MM) and are associated with morbidity and mortality. A risk score to predict the probability of early severe infection could help to identify the patients that would benefit from preventive measures. We undertook a post hoc analysis of infections in four clinical trials from the Spanish Myeloma Group, involving a total of 1347 patients (847 transplant candidates). Regarding the GEM2010 > 65 trial, antibiotic prophylaxis was mandatory, so we excluded it from the final analysis. The incidence of severe infection episodes within the first 6 months was 13.8%, and majority of the patients experiencing the first episode before 4 months (11.1%). 1.2% of patients died because of infections within the first 6 months (1% before 4 months). Variables associated with increased risk of severe infection in the first 4 months included serum albumin <= 30 g/L, ECOG > 1, male sex, and non-IgA type MM. A simple risk score with these variables facilitated the identification of three risk groups with different probabilities of severe infection within the first 4 months: low-risk (score 0-2) 8.2%; intermediate-risk (score 3) 19.2%; and high-risk (score 4) 28.3%. Patients with intermediate/high risk could be candidates for prophylactic antibiotic therapies.Springer Science and Business Media LLC2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/185581Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1038/s41408-022-00652-2Blood Cancer Journal, 2022, vol. 12, num. 4https://doi.org/10.1038/s41408-022-00652-2cc by (c) Encinas, Cristina et al, 2022http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1855812026-05-27T06:46:51Z
dc.title.none.fl_str_mv	A simple score to predict early severe infections in patients with newly diagnosed multiple myeloma
title	A simple score to predict early severe infections in patients with newly diagnosed multiple myeloma
spellingShingle	A simple score to predict early severe infections in patients with newly diagnosed multiple myeloma Encinas, Cristina Mieloma múltiple Antibiòtics Multiple myeloma Antibiotics
title_short	A simple score to predict early severe infections in patients with newly diagnosed multiple myeloma
title_full	A simple score to predict early severe infections in patients with newly diagnosed multiple myeloma
title_fullStr	A simple score to predict early severe infections in patients with newly diagnosed multiple myeloma
title_full_unstemmed	A simple score to predict early severe infections in patients with newly diagnosed multiple myeloma
title_sort	A simple score to predict early severe infections in patients with newly diagnosed multiple myeloma
dc.creator.none.fl_str_mv	Encinas, Cristina Hernandez Rivas, José Ángel Oriol, Albert Rosiñol Dachs, Laura Blanchard, María Jesús Bellón, José María García Sanz, Ramón Rubia, Javier de la López de la Guía, Ana Jímenez Ubieto, Ana Jarque, Isidro Iñigo, Belén Dourdil, Victoria Arriba, Felipe de Cuéllar Pérez-Ávila, Clara Gonzalez, Yolanda Hernández, Miguel Teodoro Bargay, Joan Granell, Miguel Rodríguez Otero, Paula Silvent, Maialen Cabrera, Carmen Rios, Rafael Alegre, Adrián Gironella, Mercedes Gonzalez, Marta Sonia Sureda, Anna Sampol, Antonia Ocio, Enrique M. Krsnik, Isabel García, Antonio García Mateo, Aránzazu Soler, Joan Alfons Martín, Jesús Arguiñano Pérez, José Mª Mateos, María Victoria Bladé, J. (Joan) San Miguel, Jesús F. Lahuerta, Juan José Martínez López, Joaquín Gem/pethema (Grupo Español de Mieloma/Programa para el estudio de la terapéutica en hemopatías malignas) Cooperative Study Group
author	Encinas, Cristina
author_facet	Encinas, Cristina Hernandez Rivas, José Ángel Oriol, Albert Rosiñol Dachs, Laura Blanchard, María Jesús Bellón, José María García Sanz, Ramón Rubia, Javier de la López de la Guía, Ana Jímenez Ubieto, Ana Jarque, Isidro Iñigo, Belén Dourdil, Victoria Arriba, Felipe de Cuéllar Pérez-Ávila, Clara Gonzalez, Yolanda Hernández, Miguel Teodoro Bargay, Joan Granell, Miguel Rodríguez Otero, Paula Silvent, Maialen Cabrera, Carmen Rios, Rafael Alegre, Adrián Gironella, Mercedes Gonzalez, Marta Sonia Sureda, Anna Sampol, Antonia Ocio, Enrique M. Krsnik, Isabel García, Antonio García Mateo, Aránzazu Soler, Joan Alfons Martín, Jesús Arguiñano Pérez, José Mª Mateos, María Victoria Bladé, J. (Joan) San Miguel, Jesús F. Lahuerta, Juan José Martínez López, Joaquín Gem/pethema (Grupo Español de Mieloma/Programa para el estudio de la terapéutica en hemopatías malignas) Cooperative Study Group
author_role	author
author2	Hernandez Rivas, José Ángel Oriol, Albert Rosiñol Dachs, Laura Blanchard, María Jesús Bellón, José María García Sanz, Ramón Rubia, Javier de la López de la Guía, Ana Jímenez Ubieto, Ana Jarque, Isidro Iñigo, Belén Dourdil, Victoria Arriba, Felipe de Cuéllar Pérez-Ávila, Clara Gonzalez, Yolanda Hernández, Miguel Teodoro Bargay, Joan Granell, Miguel Rodríguez Otero, Paula Silvent, Maialen Cabrera, Carmen Rios, Rafael Alegre, Adrián Gironella, Mercedes Gonzalez, Marta Sonia Sureda, Anna Sampol, Antonia Ocio, Enrique M. Krsnik, Isabel García, Antonio García Mateo, Aránzazu Soler, Joan Alfons Martín, Jesús Arguiñano Pérez, José Mª Mateos, María Victoria Bladé, J. (Joan) San Miguel, Jesús F. Lahuerta, Juan José Martínez López, Joaquín Gem/pethema (Grupo Español de Mieloma/Programa para el estudio de la terapéutica en hemopatías malignas) Cooperative Study Group
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Mieloma múltiple Antibiòtics Multiple myeloma Antibiotics
topic	Mieloma múltiple Antibiòtics Multiple myeloma Antibiotics
description	Infections remain a common complication in patients with multiple myeloma (MM) and are associated with morbidity and mortality. A risk score to predict the probability of early severe infection could help to identify the patients that would benefit from preventive measures. We undertook a post hoc analysis of infections in four clinical trials from the Spanish Myeloma Group, involving a total of 1347 patients (847 transplant candidates). Regarding the GEM2010 > 65 trial, antibiotic prophylaxis was mandatory, so we excluded it from the final analysis. The incidence of severe infection episodes within the first 6 months was 13.8%, and majority of the patients experiencing the first episode before 4 months (11.1%). 1.2% of patients died because of infections within the first 6 months (1% before 4 months). Variables associated with increased risk of severe infection in the first 4 months included serum albumin <= 30 g/L, ECOG > 1, male sex, and non-IgA type MM. A simple risk score with these variables facilitated the identification of three risk groups with different probabilities of severe infection within the first 4 months: low-risk (score 0-2) 8.2%; intermediate-risk (score 3) 19.2%; and high-risk (score 4) 28.3%. Patients with intermediate/high risk could be candidates for prophylactic antibiotic therapies.
publishDate	2022
dc.date.none.fl_str_mv	2022
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://hdl.handle.net/2445/185581
url	https://hdl.handle.net/2445/185581
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	Reproducció del document publicat a: https://doi.org/10.1038/s41408-022-00652-2 Blood Cancer Journal, 2022, vol. 12, num. 4 https://doi.org/10.1038/s41408-022-00652-2
dc.rights.none.fl_str_mv	cc by (c) Encinas, Cristina et al, 2022 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess
rights_invalid_str_mv	cc by (c) Encinas, Cristina et al, 2022 http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	Springer Science and Business Media LLC
publisher.none.fl_str_mv	Springer Science and Business Media LLC
dc.source.none.fl_str_mv	Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) reponame:Dipòsit Digital de la UB instname:Universidad de Barcelona
instname_str	Universidad de Barcelona
reponame_str	Dipòsit Digital de la UB
collection	Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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A simple score to predict early severe infections in patients with newly diagnosed multiple myeloma

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