A simple score to predict early severe infections in patients with newly diagnosed multiple myeloma

Infections remain a common complication in patients with multiple myeloma (MM) and are associated with morbidity and mortality. A risk score to predict the probability of early severe infection could help to identify the patients that would benefit from preventive measures. We undertook a post hoc a...

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Detalles Bibliográficos
Autores: Encinas, Cristina, Hernandez Rivas, José Ángel, Oriol, Albert, Rosiñol Dachs, Laura, Blanchard, María Jesús, Bellón, José María, García Sanz, Ramón, Rubia, Javier de la, López de la Guía, Ana, Jímenez Ubieto, Ana, Jarque, Isidro, Iñigo, Belén, Dourdil, Victoria, Arriba, Felipe de, Cuéllar Pérez-Ávila, Clara, Gonzalez, Yolanda, Hernández, Miguel Teodoro, Bargay, Joan, Granell, Miguel, Rodríguez Otero, Paula, Silvent, Maialen, Cabrera, Carmen, Rios, Rafael, Alegre, Adrián, Gironella, Mercedes, Gonzalez, Marta Sonia, Sureda, Anna, Sampol, Antonia, Ocio, Enrique M., Krsnik, Isabel, García, Antonio, García Mateo, Aránzazu, Soler, Joan Alfons, Martín, Jesús, Arguiñano Pérez, José Mª, Mateos, María Victoria, Bladé, J. (Joan), San Miguel, Jesús F., Lahuerta, Juan José, Martínez López, Joaquín, Gem/pethema (Grupo Español de Mieloma/Programa para el estudio de la terapéutica en hemopatías malignas) Cooperative Study Group
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/185581
Acceso en línea:https://hdl.handle.net/2445/185581
Access Level:acceso abierto
Palabra clave:Mieloma múltiple
Antibiòtics
Multiple myeloma
Antibiotics
Descripción
Sumario:Infections remain a common complication in patients with multiple myeloma (MM) and are associated with morbidity and mortality. A risk score to predict the probability of early severe infection could help to identify the patients that would benefit from preventive measures. We undertook a post hoc analysis of infections in four clinical trials from the Spanish Myeloma Group, involving a total of 1347 patients (847 transplant candidates). Regarding the GEM2010 > 65 trial, antibiotic prophylaxis was mandatory, so we excluded it from the final analysis. The incidence of severe infection episodes within the first 6 months was 13.8%, and majority of the patients experiencing the first episode before 4 months (11.1%). 1.2% of patients died because of infections within the first 6 months (1% before 4 months). Variables associated with increased risk of severe infection in the first 4 months included serum albumin <= 30 g/L, ECOG > 1, male sex, and non-IgA type MM. A simple risk score with these variables facilitated the identification of three risk groups with different probabilities of severe infection within the first 4 months: low-risk (score 0-2) 8.2%; intermediate-risk (score 3) 19.2%; and high-risk (score 4) 28.3%. Patients with intermediate/high risk could be candidates for prophylactic antibiotic therapies.

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