A Sustainable Approach for Extracting Non-Extractable Phenolic Compounds from Mangosteen Peel Using Ultrasound-Assisted Extraction and Natural Deep Eutectic Solvents

Mangosteen (Garcinia mangostana L.) peel is a potential source of phenolic compounds with beneficial properties. Natural deep eutectic solvents (NaDES) have been considered an environmentally friendly and cheap alternative to conventional organic solvents. In this work, a green extraction methodolog...

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Authors: Marina Alegre, María Luisa|||0000-0002-5583-1624, Plaza del Moral, Merichel|||0000-0002-9636-6458, Domínguez Rodríguez, Gloria|||0000-0002-4013-4201, Sahelices Garrido-Lestache, Cristina
Format: article
Publication Date:2021
Country:España
Institution:Universidad de Alcalá (UAH)
Repository:e_Buah Biblioteca Digital Universidad de Alcalá
Language:English
OAI Identifier:oai:ebuah.uah.es:10017/48667
Online Access:http://hdl.handle.net/10017/48667
https://dx.doi.org/10.3390/app11125625
Access Level:Open access
Keyword:natural deep eutectic solvent
sustainable extraction
non-extractable polyphenols
mangosteen peel
ultrasound-assisted extraction
response surface methodology
Química
Chemistry
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spelling A Sustainable Approach for Extracting Non-Extractable Phenolic Compounds from Mangosteen Peel Using Ultrasound-Assisted Extraction and Natural Deep Eutectic SolventsMarina Alegre, María Luisa|||0000-0002-5583-1624Plaza del Moral, Merichel|||0000-0002-9636-6458Domínguez Rodríguez, Gloria|||0000-0002-4013-4201Sahelices Garrido-Lestache, Cristinanatural deep eutectic solventsustainable extractionnon-extractable polyphenolsmangosteen peelultrasound-assisted extractionresponse surface methodologyQuímicaChemistryMangosteen (Garcinia mangostana L.) peel is a potential source of phenolic compounds with beneficial properties. Natural deep eutectic solvents (NaDES) have been considered an environmentally friendly and cheap alternative to conventional organic solvents. In this work, a green extraction methodology was developed using ultrasound-assisted extraction (UAE) and NaDES for the extraction of antioxidant non-extractable polyphenols (NEPs) from mangosteen peel. To select the best NaDES to extract NEPs from mangosteen peel, seven NaDES were studied. Antioxidant capacity and total phenolic and proanthocyanidin contents were determined for the extracts. The molecular weights for the NEPs present in those extracts were evaluated by size exclusion chromatography. Experimental results showed that choline chloride&-lactic acid (1:2) was the NaDES allowing the highest antioxidant proanthocyanidin content in the extracts. A Box&-Behnken experimental design was employed to optimize the main parameters in UAE with NaDES: water percentage, ultrasound amplitude, and extraction time. The optimal extraction conditions were 18.8% (v/v) water, 60% ultrasound amplitude, and 15 min as the extraction time. In addition, the cytotoxicity of the NEP extracts obtained under optimal extraction conditions was evaluated. Results indicated for the first time that the use of NaDES in combination with UAE could be a sustainable alternative for the extraction of antioxidant NEPs from mangosteen peel for important applications in the food, pharmaceutical, agrochemical, and cosmetic fields, as the extracts presented low cytotoxicity.Comunidad de MadridUniversidad de Alcalá20212021-06-18journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10017/48667https://dx.doi.org/10.3390/app11125625reponame:e_Buah Biblioteca Digital Universidad de Alcaláinstname:Universidad de Alcalá (UAH)InglésengUAH Not available CM%2FJIN%2F2019-033 SOSBIOComunidad de Madrid http://dx.doi.org/10.13039/100012818 Not available S2018%2FBAA-4393 Estrategias integradas para la mejora de la calidad, la seguridad y la funcionalidad de los alimentos: hacia una alimentación saludableopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-ShareAlike 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/openAccessoai:ebuah.uah.es:10017/486672026-06-18T11:13:07Z
dc.title.none.fl_str_mv A Sustainable Approach for Extracting Non-Extractable Phenolic Compounds from Mangosteen Peel Using Ultrasound-Assisted Extraction and Natural Deep Eutectic Solvents
title A Sustainable Approach for Extracting Non-Extractable Phenolic Compounds from Mangosteen Peel Using Ultrasound-Assisted Extraction and Natural Deep Eutectic Solvents
spellingShingle A Sustainable Approach for Extracting Non-Extractable Phenolic Compounds from Mangosteen Peel Using Ultrasound-Assisted Extraction and Natural Deep Eutectic Solvents
Marina Alegre, María Luisa|||0000-0002-5583-1624
natural deep eutectic solvent
sustainable extraction
non-extractable polyphenols
mangosteen peel
ultrasound-assisted extraction
response surface methodology
Química
Chemistry
title_short A Sustainable Approach for Extracting Non-Extractable Phenolic Compounds from Mangosteen Peel Using Ultrasound-Assisted Extraction and Natural Deep Eutectic Solvents
title_full A Sustainable Approach for Extracting Non-Extractable Phenolic Compounds from Mangosteen Peel Using Ultrasound-Assisted Extraction and Natural Deep Eutectic Solvents
title_fullStr A Sustainable Approach for Extracting Non-Extractable Phenolic Compounds from Mangosteen Peel Using Ultrasound-Assisted Extraction and Natural Deep Eutectic Solvents
title_full_unstemmed A Sustainable Approach for Extracting Non-Extractable Phenolic Compounds from Mangosteen Peel Using Ultrasound-Assisted Extraction and Natural Deep Eutectic Solvents
title_sort A Sustainable Approach for Extracting Non-Extractable Phenolic Compounds from Mangosteen Peel Using Ultrasound-Assisted Extraction and Natural Deep Eutectic Solvents
dc.creator.none.fl_str_mv Marina Alegre, María Luisa|||0000-0002-5583-1624
Plaza del Moral, Merichel|||0000-0002-9636-6458
Domínguez Rodríguez, Gloria|||0000-0002-4013-4201
Sahelices Garrido-Lestache, Cristina
author Marina Alegre, María Luisa|||0000-0002-5583-1624
author_facet Marina Alegre, María Luisa|||0000-0002-5583-1624
Plaza del Moral, Merichel|||0000-0002-9636-6458
Domínguez Rodríguez, Gloria|||0000-0002-4013-4201
Sahelices Garrido-Lestache, Cristina
author_role author
author2 Plaza del Moral, Merichel|||0000-0002-9636-6458
Domínguez Rodríguez, Gloria|||0000-0002-4013-4201
Sahelices Garrido-Lestache, Cristina
author2_role author
author
author
dc.subject.none.fl_str_mv natural deep eutectic solvent
sustainable extraction
non-extractable polyphenols
mangosteen peel
ultrasound-assisted extraction
response surface methodology
Química
Chemistry
topic natural deep eutectic solvent
sustainable extraction
non-extractable polyphenols
mangosteen peel
ultrasound-assisted extraction
response surface methodology
Química
Chemistry
description Mangosteen (Garcinia mangostana L.) peel is a potential source of phenolic compounds with beneficial properties. Natural deep eutectic solvents (NaDES) have been considered an environmentally friendly and cheap alternative to conventional organic solvents. In this work, a green extraction methodology was developed using ultrasound-assisted extraction (UAE) and NaDES for the extraction of antioxidant non-extractable polyphenols (NEPs) from mangosteen peel. To select the best NaDES to extract NEPs from mangosteen peel, seven NaDES were studied. Antioxidant capacity and total phenolic and proanthocyanidin contents were determined for the extracts. The molecular weights for the NEPs present in those extracts were evaluated by size exclusion chromatography. Experimental results showed that choline chloride&-lactic acid (1:2) was the NaDES allowing the highest antioxidant proanthocyanidin content in the extracts. A Box&-Behnken experimental design was employed to optimize the main parameters in UAE with NaDES: water percentage, ultrasound amplitude, and extraction time. The optimal extraction conditions were 18.8% (v/v) water, 60% ultrasound amplitude, and 15 min as the extraction time. In addition, the cytotoxicity of the NEP extracts obtained under optimal extraction conditions was evaluated. Results indicated for the first time that the use of NaDES in combination with UAE could be a sustainable alternative for the extraction of antioxidant NEPs from mangosteen peel for important applications in the food, pharmaceutical, agrochemical, and cosmetic fields, as the extracts presented low cytotoxicity.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-06-18
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10017/48667
https://dx.doi.org/10.3390/app11125625
url http://hdl.handle.net/10017/48667
https://dx.doi.org/10.3390/app11125625
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv UAH Not available CM%2FJIN%2F2019-033 SOSBIO
Comunidad de Madrid http://dx.doi.org/10.13039/100012818 Not available S2018%2FBAA-4393 Estrategias integradas para la mejora de la calidad, la seguridad y la funcionalidad de los alimentos: hacia una alimentación saludable
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-ShareAlike 4.0 International
http://creativecommons.org/licenses/by-nc-sa/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-ShareAlike 4.0 International
http://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:e_Buah Biblioteca Digital Universidad de Alcalá
instname:Universidad de Alcalá (UAH)
instname_str Universidad de Alcalá (UAH)
reponame_str e_Buah Biblioteca Digital Universidad de Alcalá
collection e_Buah Biblioteca Digital Universidad de Alcalá
repository.name.fl_str_mv
repository.mail.fl_str_mv
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