Sustainable strategies to obtain bioactive compounds from citrus peels by supercritical fluid extraction, ultrasound-assisted extraction, and naturaldeep eutectic solvents
This work proposes a sustainable sequential extraction of bioactive terpenoids and phenolic compounds from grapefruit, lime, and lemon peels using supercritical CO2 extraction (SC-CO2) and ultrasound-assisted extraction (UAE) with natural deep eutectic solvents (NaDES). NaDES screening demonstrated...
| Autores: | , , , , |
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| Formato: | artículo |
| Fecha de publicación: | 2025 |
| País: | España |
| Recursos: | Universidad de Alcalá (UAH) |
| Repositorio: | e_Buah Biblioteca Digital Universidad de Alcalá |
| Idioma: | inglés |
| OAI Identifier: | oai:ebuah.uah.es:10017/65813 |
| Acesso em linha: | http://hdl.handle.net/10017/65813 https://dx.doi.org/10.1016/j.foodres.2025.115713 |
| Access Level: | acceso abierto |
| Palavra-chave: | Bioactive compounds Phenolic compounds Terpenoids Citrus peels Ultrasound-assisted extraction Natural deep eutectic solvents Supercritical fluid extraction Cryogenic grinding Química Chemistry |
| Resumo: | This work proposes a sustainable sequential extraction of bioactive terpenoids and phenolic compounds from grapefruit, lime, and lemon peels using supercritical CO2 extraction (SC-CO2) and ultrasound-assisted extraction (UAE) with natural deep eutectic solvents (NaDES). NaDES screening demonstrated that Choline Chloride:Tartaric acid (1:2) for grapefruit and lemon peels, and Choline Chloride:Glycerol (1:2) for lime peels with 50% water yielded the highest phenolic contents. Cryogenic grinding (CR) and SC-CO2 pretreatments before UAE-NaDES did not improve phenolic recovery compared to direct UAE-NaDES. Pretreatments reduced particle size and increased surface tension, lowering UAE-NaDES efficiency. The direct UAE-NaDES extracts showed the highest phenolic diversity, with naringin in grapefruit and hesperidin in lime and lemon peels as the major compounds identified by HPLC-QTOF-MS. However, SC-CO2 obtained before UAE-NaDES presented higher anticholinergic capacity and a rich terpenoid profile identified by GC-Q-MS. Results demonstrate the potential of this sequential strategy for a more holistic exploitation of citrus peels. |
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