Sustainable strategies to obtain bioactive compounds from citrus peels by supercritical fluid extraction, ultrasound-assisted extraction, and natural deep eutectic solvents
This work proposes a sustainable sequential extraction of bioactive terpenoids and phenolic compounds from grapefruit, lime, and lemon peels using supercritical CO2 extraction (SC-CO2) and ultrasound-assisted extraction (UAE) with natural deep eutectic solvents (NaDES). NaDES screening demonstrated...
| Autores: | , , , , |
|---|---|
| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2025 |
| País: | España |
| Recursos: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/390970 |
| Acesso em linha: | http://hdl.handle.net/10261/390970 |
| Access Level: | acceso abierto |
| Palavra-chave: | Bioactive compounds Citrus peels Cryogenic grinding Natural deep eutectic solvents Phenolic compounds Supercritical fluid extraction Terpenoids Ultrasound-assisted extraction |
| Resumo: | This work proposes a sustainable sequential extraction of bioactive terpenoids and phenolic compounds from grapefruit, lime, and lemon peels using supercritical CO2 extraction (SC-CO2) and ultrasound-assisted extraction (UAE) with natural deep eutectic solvents (NaDES). NaDES screening demonstrated that Choline Chloride:Tartaric acid (1:2) for grapefruit and lemon peels, and Choline Chloride:Glycerol (1:2) for lime peels with 50% water yielded the highest phenolic contents. Cryogenic grinding (CR) and SC-CO2 pretreatments before UAE-NaDES did not improve phenolic recovery compared to direct UAE-NaDES. Pretreatments reduced particle size and increased surface tension, lowering UAE-NaDES efficiency. The direct UAE-NaDES extracts showed the highest phenolic diversity, with naringin in grapefruit and hesperidin in lime and lemon peels as the major compounds identified by HPLC-QTOF-MS. However, SC-CO2 obtained before UAE-NaDES presented higher anticholinergic capacity and a rich terpenoid profile identified by GC-Q-MS. Results demonstrate the potential of this sequential strategy for a more holistic exploitation of citrus peels. |
|---|