Identifying comorbidities and lifestyle factors contributing to the cognitive profile of early Parkinson’s disease

Martínez-Horta, Saul; Berj-Kasem, Helena; Horta-Barba, Andrea; Pascual Sedano, Berta; Santos García, Diego; Deus-Fonticoba, Teresa de; Jesús, Silvia; Aguilar, Miquel; Planellás, Lluis L.; García Caldentey, Juan; Caballol, Núria; Vives Pastor, Bárbara; Hernández Vara, Jorge; Cabo López, Iria; López Manzanares, Lydia; González Aramburu, Isabel; Ávila Rivera, María A.; Catalán, María José; López Díaz, Luis M.; Puente, Víctor; García Moreno, José Manuel; Borrue, Carmen; Solano Vila, Berta; Álvarez Saúco, María; Vela Desojo, Lydia; Escalante Arroyo, Sonia; Cubo Delgado, Esther; Carrillo Padilla, Francisco; Martínez Castrillo, Juan Carlos; Sánchez Alonso, Pilar; Alonso Losada, María Gema; López Ariztegui, Nuria; Gastón, Itziar; Blázquez Estrada, Marta; Seijo, Manuel; Ruíz Martínez, Javier; Valero, Caridad; Kurtis, Mónica M.; Fabregues, Oriol de; González Ardura, Jessica; Prieto Jurczynska, Cristina; Martínez Martín, Pablo; Mir, Pablo; Kulisevsky Bojarsky, Jaume; COPPADIS Study Group

Identifying comorbidities and lifestyle factors contributing to the cognitive profile of early Parkinson’s disease

Background: Identifying modifable risk factors for cognitive impairment in the early stages of Parkinson’s disease (PD) and estimating their impact on cognitive status may help prevent dementia (PDD) and the design of cognitive trials. Methods: Using a standard approach for the assessment of global...

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Autores:	Martínez-Horta, Saul, Berj-Kasem, Helena, Horta-Barba, Andrea, Pascual Sedano, Berta, Santos García, Diego, Deus-Fonticoba, Teresa de, Jesús, Silvia, Aguilar, Miquel, Planellás, Lluis L., García Caldentey, Juan, Caballol, Núria, Vives Pastor, Bárbara, Hernández Vara, Jorge, Cabo López, Iria, López Manzanares, Lydia, González Aramburu, Isabel, Ávila Rivera, María A., Catalán, María José, López Díaz, Luis M., Puente, Víctor, García Moreno, José Manuel, Borrue, Carmen, Solano Vila, Berta, Álvarez Saúco, María, Vela Desojo, Lydia, Escalante Arroyo, Sonia, Cubo Delgado, Esther, Carrillo Padilla, Francisco, Martínez Castrillo, Juan Carlos, Sánchez Alonso, Pilar, Alonso Losada, María Gema, López Ariztegui, Nuria, Gastón, Itziar, Blázquez Estrada, Marta, Seijo, Manuel, Ruíz Martínez, Javier, Valero, Caridad, Kurtis, Mónica M., Fabregues, Oriol de, González Ardura, Jessica, Prieto Jurczynska, Cristina, Martínez Martín, Pablo, Mir, Pablo, Kulisevsky Bojarsky, Jaume, COPPADIS Study Group
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2021
País:	España
Institución:	Universidad de Burgos (UBU)
Repositorio:	Repositorio Institucional de la Universidad de Burgos (RIUBU)
OAI Identifier:	oai:riubu.ubu.es:10259/8809
Acceso en línea:	http://hdl.handle.net/10259/8809
Access Level:	acceso abierto
Palabra clave:	Parkinson’s disease PD-MCI Cognition Lifestyle Coppadis Sistema nervioso-Enfermedades Medicina Neurología Nervous system-Diseases Medicine Neurology

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spelling	Identifying comorbidities and lifestyle factors contributing to the cognitive profile of early Parkinson’s diseaseMartínez-Horta, SaulBerj-Kasem, HelenaHorta-Barba, AndreaPascual Sedano, BertaSantos García, DiegoDeus-Fonticoba, Teresa deJesús, SilviaAguilar, MiquelPlanellás, Lluis L.García Caldentey, JuanCaballol, NúriaVives Pastor, BárbaraHernández Vara, JorgeCabo López, IriaLópez Manzanares, LydiaGonzález Aramburu, IsabelÁvila Rivera, María A.Catalán, María JoséLópez Díaz, Luis M.Puente, VíctorGarcía Moreno, José ManuelBorrue, CarmenSolano Vila, BertaÁlvarez Saúco, MaríaVela Desojo, LydiaEscalante Arroyo, SoniaCubo Delgado, EstherCarrillo Padilla, FranciscoMartínez Castrillo, Juan CarlosSánchez Alonso, PilarAlonso Losada, María GemaLópez Ariztegui, NuriaGastón, ItziarBlázquez Estrada, MartaSeijo, ManuelRuíz Martínez, JavierValero, CaridadKurtis, Mónica M.Fabregues, Oriol deGonzález Ardura, JessicaPrieto Jurczynska, CristinaMartínez Martín, PabloMir, PabloKulisevsky Bojarsky, JaumeCOPPADIS Study GroupParkinson’s diseasePD-MCICognitionLifestyleCoppadisSistema nervioso-EnfermedadesMedicinaNeurologíaNervous system-DiseasesMedicineNeurologyBackground: Identifying modifable risk factors for cognitive impairment in the early stages of Parkinson’s disease (PD) and estimating their impact on cognitive status may help prevent dementia (PDD) and the design of cognitive trials. Methods: Using a standard approach for the assessment of global cognition in PD and controlling for the efects of age, education and disease duration, we explored the associations between cognitive status, comorbidities, meta‑ bolic variables and lifestyle variables in 533 PD participants from the COPPADIS study. Results: Among the overall sample, 21% of participants were classifed as PD-MCI (n=114) and 4% as PDD (n=26). The prevalence of hypertension, diabetes and dyslipidemia was signifcantly higher in cognitively impaired patients while no between-group diferences were found for smoking, alcohol intake or use of supplementary vitamins. Bet‑ ter cognitive scores were signifcantly associated with regular physical exercise (p<0.05) and cognitive stimulation (<0.01). Cognitive performance was negatively associated with interleukin 2 (Il2) (p<0.05), Il6 (p<0.05), iron (p<0.05), and homocysteine (p<0.005) levels, and positively associated with vitamin B12 levels (p<0.005). Conclusions: We extend previous fndings regarding the positive and negative infuence of various comorbidities and lifestyle factors on cognitive status in early PD patients, and reinforce the need to identify and treat potentiallySpringer Nature202420242021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10259/8809reponame:Repositorio Institucional de la Universidad de Burgos (RIUBU)instname:Universidad de Burgos (UBU)InglésBMC Neurology. 2021, V. 21, n. 1https://doi.org/10.1186/s12883-021-02485-1Atribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:riubu.ubu.es:10259/88092026-05-28T07:56:11Z
dc.title.none.fl_str_mv	Identifying comorbidities and lifestyle factors contributing to the cognitive profile of early Parkinson’s disease
title	Identifying comorbidities and lifestyle factors contributing to the cognitive profile of early Parkinson’s disease
spellingShingle	Identifying comorbidities and lifestyle factors contributing to the cognitive profile of early Parkinson’s disease Martínez-Horta, Saul Parkinson’s disease PD-MCI Cognition Lifestyle Coppadis Sistema nervioso-Enfermedades Medicina Neurología Nervous system-Diseases Medicine Neurology
title_short	Identifying comorbidities and lifestyle factors contributing to the cognitive profile of early Parkinson’s disease
title_full	Identifying comorbidities and lifestyle factors contributing to the cognitive profile of early Parkinson’s disease
title_fullStr	Identifying comorbidities and lifestyle factors contributing to the cognitive profile of early Parkinson’s disease
title_full_unstemmed	Identifying comorbidities and lifestyle factors contributing to the cognitive profile of early Parkinson’s disease
title_sort	Identifying comorbidities and lifestyle factors contributing to the cognitive profile of early Parkinson’s disease
dc.creator.none.fl_str_mv	Martínez-Horta, Saul Berj-Kasem, Helena Horta-Barba, Andrea Pascual Sedano, Berta Santos García, Diego Deus-Fonticoba, Teresa de Jesús, Silvia Aguilar, Miquel Planellás, Lluis L. García Caldentey, Juan Caballol, Núria Vives Pastor, Bárbara Hernández Vara, Jorge Cabo López, Iria López Manzanares, Lydia González Aramburu, Isabel Ávila Rivera, María A. Catalán, María José López Díaz, Luis M. Puente, Víctor García Moreno, José Manuel Borrue, Carmen Solano Vila, Berta Álvarez Saúco, María Vela Desojo, Lydia Escalante Arroyo, Sonia Cubo Delgado, Esther Carrillo Padilla, Francisco Martínez Castrillo, Juan Carlos Sánchez Alonso, Pilar Alonso Losada, María Gema López Ariztegui, Nuria Gastón, Itziar Blázquez Estrada, Marta Seijo, Manuel Ruíz Martínez, Javier Valero, Caridad Kurtis, Mónica M. Fabregues, Oriol de González Ardura, Jessica Prieto Jurczynska, Cristina Martínez Martín, Pablo Mir, Pablo Kulisevsky Bojarsky, Jaume COPPADIS Study Group
author	Martínez-Horta, Saul
author_facet	Martínez-Horta, Saul Berj-Kasem, Helena Horta-Barba, Andrea Pascual Sedano, Berta Santos García, Diego Deus-Fonticoba, Teresa de Jesús, Silvia Aguilar, Miquel Planellás, Lluis L. García Caldentey, Juan Caballol, Núria Vives Pastor, Bárbara Hernández Vara, Jorge Cabo López, Iria López Manzanares, Lydia González Aramburu, Isabel Ávila Rivera, María A. Catalán, María José López Díaz, Luis M. Puente, Víctor García Moreno, José Manuel Borrue, Carmen Solano Vila, Berta Álvarez Saúco, María Vela Desojo, Lydia Escalante Arroyo, Sonia Cubo Delgado, Esther Carrillo Padilla, Francisco Martínez Castrillo, Juan Carlos Sánchez Alonso, Pilar Alonso Losada, María Gema López Ariztegui, Nuria Gastón, Itziar Blázquez Estrada, Marta Seijo, Manuel Ruíz Martínez, Javier Valero, Caridad Kurtis, Mónica M. Fabregues, Oriol de González Ardura, Jessica Prieto Jurczynska, Cristina Martínez Martín, Pablo Mir, Pablo Kulisevsky Bojarsky, Jaume COPPADIS Study Group
author_role	author
author2	Berj-Kasem, Helena Horta-Barba, Andrea Pascual Sedano, Berta Santos García, Diego Deus-Fonticoba, Teresa de Jesús, Silvia Aguilar, Miquel Planellás, Lluis L. García Caldentey, Juan Caballol, Núria Vives Pastor, Bárbara Hernández Vara, Jorge Cabo López, Iria López Manzanares, Lydia González Aramburu, Isabel Ávila Rivera, María A. Catalán, María José López Díaz, Luis M. Puente, Víctor García Moreno, José Manuel Borrue, Carmen Solano Vila, Berta Álvarez Saúco, María Vela Desojo, Lydia Escalante Arroyo, Sonia Cubo Delgado, Esther Carrillo Padilla, Francisco Martínez Castrillo, Juan Carlos Sánchez Alonso, Pilar Alonso Losada, María Gema López Ariztegui, Nuria Gastón, Itziar Blázquez Estrada, Marta Seijo, Manuel Ruíz Martínez, Javier Valero, Caridad Kurtis, Mónica M. Fabregues, Oriol de González Ardura, Jessica Prieto Jurczynska, Cristina Martínez Martín, Pablo Mir, Pablo Kulisevsky Bojarsky, Jaume COPPADIS Study Group
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Parkinson’s disease PD-MCI Cognition Lifestyle Coppadis Sistema nervioso-Enfermedades Medicina Neurología Nervous system-Diseases Medicine Neurology
topic	Parkinson’s disease PD-MCI Cognition Lifestyle Coppadis Sistema nervioso-Enfermedades Medicina Neurología Nervous system-Diseases Medicine Neurology
description	Background: Identifying modifable risk factors for cognitive impairment in the early stages of Parkinson’s disease (PD) and estimating their impact on cognitive status may help prevent dementia (PDD) and the design of cognitive trials. Methods: Using a standard approach for the assessment of global cognition in PD and controlling for the efects of age, education and disease duration, we explored the associations between cognitive status, comorbidities, meta‑ bolic variables and lifestyle variables in 533 PD participants from the COPPADIS study. Results: Among the overall sample, 21% of participants were classifed as PD-MCI (n=114) and 4% as PDD (n=26). The prevalence of hypertension, diabetes and dyslipidemia was signifcantly higher in cognitively impaired patients while no between-group diferences were found for smoking, alcohol intake or use of supplementary vitamins. Bet‑ ter cognitive scores were signifcantly associated with regular physical exercise (p<0.05) and cognitive stimulation (<0.01). Cognitive performance was negatively associated with interleukin 2 (Il2) (p<0.05), Il6 (p<0.05), iron (p<0.05), and homocysteine (p<0.005) levels, and positively associated with vitamin B12 levels (p<0.005). Conclusions: We extend previous fndings regarding the positive and negative infuence of various comorbidities and lifestyle factors on cognitive status in early PD patients, and reinforce the need to identify and treat potentially
publishDate	2021
dc.date.none.fl_str_mv	2021 2024 2024
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	http://hdl.handle.net/10259/8809
url	http://hdl.handle.net/10259/8809
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	BMC Neurology. 2021, V. 21, n. 1 https://doi.org/10.1186/s12883-021-02485-1
dc.rights.none.fl_str_mv	Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess
rights_invalid_str_mv	Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	Springer Nature
publisher.none.fl_str_mv	Springer Nature
dc.source.none.fl_str_mv	reponame:Repositorio Institucional de la Universidad de Burgos (RIUBU) instname:Universidad de Burgos (UBU)
instname_str	Universidad de Burgos (UBU)
reponame_str	Repositorio Institucional de la Universidad de Burgos (RIUBU)
collection	Repositorio Institucional de la Universidad de Burgos (RIUBU)
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repository.mail.fl_str_mv
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Identifying comorbidities and lifestyle factors contributing to the cognitive profile of early Parkinson’s disease

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