Identifying comorbidities and lifestyle factors contributing to the cognitive profile of early Parkinson’s disease

Background: Identifying modifable risk factors for cognitive impairment in the early stages of Parkinson’s disease (PD) and estimating their impact on cognitive status may help prevent dementia (PDD) and the design of cognitive trials. Methods: Using a standard approach for the assessment of global...

Descripción completa

Detalles Bibliográficos
Autores: Martínez-Horta, Saul, Berj-Kasem, Helena, Horta-Barba, Andrea, Pascual Sedano, Berta, Santos García, Diego, Deus-Fonticoba, Teresa de, Jesús, Silvia, Aguilar, Miquel, Planellás, Lluis L., García Caldentey, Juan, Caballol, Núria, Vives Pastor, Bárbara, Hernández Vara, Jorge, Cabo López, Iria, López Manzanares, Lydia, González Aramburu, Isabel, Ávila Rivera, María A., Catalán, María José, López Díaz, Luis M., Puente, Víctor, García Moreno, José Manuel, Borrue, Carmen, Solano Vila, Berta, Álvarez Saúco, María, Vela Desojo, Lydia, Escalante Arroyo, Sonia, Cubo Delgado, Esther, Carrillo Padilla, Francisco, Martínez Castrillo, Juan Carlos, Sánchez Alonso, Pilar, Alonso Losada, María Gema, López Ariztegui, Nuria, Gastón, Itziar, Blázquez Estrada, Marta, Seijo, Manuel, Ruíz Martínez, Javier, Valero, Caridad, Kurtis, Mónica M., Fabregues, Oriol de, González Ardura, Jessica, Prieto Jurczynska, Cristina, Martínez Martín, Pablo, Mir, Pablo, Kulisevsky Bojarsky, Jaume, COPPADIS Study Group
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universidad de Burgos (UBU)
Repositorio:Repositorio Institucional de la Universidad de Burgos (RIUBU)
OAI Identifier:oai:riubu.ubu.es:10259/8809
Acceso en línea:http://hdl.handle.net/10259/8809
Access Level:acceso abierto
Palabra clave:Parkinson’s disease
PD-MCI
Cognition
Lifestyle
Coppadis
Sistema nervioso-Enfermedades
Medicina
Neurología
Nervous system-Diseases
Medicine
Neurology
Descripción
Sumario:Background: Identifying modifable risk factors for cognitive impairment in the early stages of Parkinson’s disease (PD) and estimating their impact on cognitive status may help prevent dementia (PDD) and the design of cognitive trials. Methods: Using a standard approach for the assessment of global cognition in PD and controlling for the efects of age, education and disease duration, we explored the associations between cognitive status, comorbidities, meta‑ bolic variables and lifestyle variables in 533 PD participants from the COPPADIS study. Results: Among the overall sample, 21% of participants were classifed as PD-MCI (n=114) and 4% as PDD (n=26). The prevalence of hypertension, diabetes and dyslipidemia was signifcantly higher in cognitively impaired patients while no between-group diferences were found for smoking, alcohol intake or use of supplementary vitamins. Bet‑ ter cognitive scores were signifcantly associated with regular physical exercise (p<0.05) and cognitive stimulation (<0.01). Cognitive performance was negatively associated with interleukin 2 (Il2) (p<0.05), Il6 (p<0.05), iron (p<0.05), and homocysteine (p<0.005) levels, and positively associated with vitamin B12 levels (p<0.005). Conclusions: We extend previous fndings regarding the positive and negative infuence of various comorbidities and lifestyle factors on cognitive status in early PD patients, and reinforce the need to identify and treat potentially

Similares en LA Referencia