Identifying comorbidities and lifestyle factors contributing to the cognitive profile of early Parkinson's disease

Background: Identifying modifiable risk factors for cognitive impairment in the early stages of Parkinson's disease (PD) and estimating their impact on cognitive status may help prevent dementia (PDD) and the design of cognitive trials. Methods: Using a standard approach for the assessment of g...

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Autores: Martínez-Horta, Saul|||0000-0003-0125-7249, Bejr-kasem, Helena|||0000-0001-8828-5976, Horta-Barba, Andrea|||0000-0003-0050-5466, Pascual Sedano, Berta María|||0000-0002-9298-8241, Santos García, Diego|||0000-0002-3126-5111, de Deus Fonticoba, Teresa, Jesús, Silvia, Aguilar Barberà, Miquel, Planellas, Lluis|||0000-0002-0769-6675, García-Caldentey, Juan, Caballol, Nuria|||0000-0003-3363-3077, Vives-Pastor, Bárbara, Hernández-Vara, Jorge|||0000-0002-9129-5224, Cabo-Lopez, Iria|||0000-0003-2436-6499, López Manzanares, Lydia|||0000-0003-4615-4542, Gonzalez-Aramburu, Isabel|||0000-0002-3696-4093, Ávila, Asunción|||0000-0001-8357-0751, Catalán Alonso, Maria José, López-Díaz, Luis Manuel, Puente, Victor, García Moreno, José Manuel, Borrué, Carmen, Solano Vila, Berta|||0009-0007-8945-0487, Álvarez Sauco, María, Vela, Lydia|||0000-0001-6663-395X, Escalante, Sonia|||0000-0001-8931-1400, Cubo, Esther|||0000-0003-0018-1182, Carrillo Padilla, Francisco, Martínez-Castrillo, Juan Carlos|||0000-0001-7744-6850, Sánchez Alonso, Pilar|||0000-0003-0496-4707, Alonso-Losada, Maria Gema, López-Ariztegui, Nuria, Gastón, Itziar, Blázquez Estrada, Marta|||0000-0003-3348-9992, Seijo-Martínez, Manuel, Rúiz-Martínez, Javier, Valero, Caridad, Kurtis, Mónica|||0000-0003-3037-9712, Fàbregues-Boixar i Nebot, Oriol de|||0000-0002-3518-5338, González-Ardura, Jessica, Prieto-Jurczynska, Cristina, Martinez-Martin, Pablo|||0000-0003-0837-5280, Mir, Pablo|||0000-0003-1656-302X, Kulisevsky, Jaime|||0000-0003-4870-1431
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:264465
Acceso en línea:https://ddd.uab.cat/record/264465
https://dx.doi.org/urn:doi:10.1186/s12883-021-02485-1
Access Level:acceso abierto
Palabra clave:Cognition
Coppadis
Lifestyle
PD-MCI
Parkinson's disease
Descripción
Sumario:Background: Identifying modifiable risk factors for cognitive impairment in the early stages of Parkinson's disease (PD) and estimating their impact on cognitive status may help prevent dementia (PDD) and the design of cognitive trials. Methods: Using a standard approach for the assessment of global cognition in PD and controlling for the effects of age, education and disease duration, we explored the associations between cognitive status, comorbidities, metabolic variables and lifestyle variables in 533 PD participants from the COPPADIS study. Results: Among the overall sample, 21% of participants were classified as PD-MCI (n = 114) and 4% as PDD (n = 26). The prevalence of hypertension, diabetes and dyslipidemia was significantly higher in cognitively impaired patients while no between-group differences were found for smoking, alcohol intake or use of supplementary vitamins. Better cognitive scores were significantly associated with regular physical exercise (p < 0.05) and cognitive stimulation (< 0.01). Cognitive performance was negatively associated with interleukin 2 (Il2) (p < 0.05), Il6 (p < 0.05), iron (p < 0.05), and homocysteine (p < 0.005) levels, and positively associated with vitamin B12 levels (p < 0.005). Conclusions: We extend previous findings regarding the positive and negative influence of various comorbidities and lifestyle factors on cognitive status in early PD patients, and reinforce the need to identify and treat potentially modifiable variables with the intention of exploring the possible improvement of the global cognitive status of patients with PD.

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