Medically Biodegradable Hydrogenated Amorphous Silicon Microspheres

[EN] Hydrogenated amorphous silicon colloids of low surface area (<5 m(2)/g) are shown to exhibit complete in-vitro biodegradation into orthosilicic acid within 10-15 days at 37 degrees C. When converted into polycrystalline silicon colloids, by high temperature annealing in an inert atmosphe...

Descripción completa

Detalles Bibliográficos
Autores: Shabir, Q., Pokale, A., Loni, A., Johnson, D. R., Canham, L.T., Tymczenko, Michal Konrad, Rodríguez, Marie-Isabelle, Cros, Ana, Cantarero, Andrés, Fenollosa Esteve, Roberto|||0000-0003-2758-9823, MESEGUER RICO, FRANCISCO JAVIER|||0000-0002-5541-9912
Tipo de recurso: artículo
Fecha de publicación:2011
País:España
Institución:Universitat Politècnica de València (UPV)
Repositorio:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
Idioma:inglés
OAI Identifier:oai:riunet.upv.es:10251/84338
Acceso en línea:https://riunet.upv.es/handle/10251/84338
Access Level:acceso abierto
Palabra clave:Silicon
Amorphous.
Biodegradable
Medical
id ES_d6ff94fb33e2fdca7b4b6c392cf7be1b
oai_identifier_str oai:riunet.upv.es:10251/84338
network_acronym_str ES
network_name_str España
repository_id_str
spelling Medically Biodegradable Hydrogenated Amorphous Silicon MicrospheresShabir, Q.Pokale, A.Loni, A.Johnson, D. R.Canham, L.T.Tymczenko, Michal KonradRodríguez, Marie-IsabelleCros, AnaCantarero, AndrésFenollosa Esteve, Roberto|||0000-0003-2758-9823MESEGUER RICO, FRANCISCO JAVIER|||0000-0002-5541-9912SiliconAmorphous.BiodegradableMedical[EN] Hydrogenated amorphous silicon colloids of low surface area (<5 m(2)/g) are shown to exhibit complete in-vitro biodegradation into orthosilicic acid within 10-15 days at 37 degrees C. When converted into polycrystalline silicon colloids, by high temperature annealing in an inert atmosphere, microparticle solubility is dramatically reduced. The data suggests that amorphous silicon does not require nanoscale porosification for full in-vivo biodegradability. This has significant implications for using a-Si:H coatings for medical implants in general, and orthopedic implants in particular. The high sphericity and biodegradability of submicron particles may also confer advantages with regards to contrast agents for medical imaging.This work has been partially supported by the Spanish CICyT projects, FIS2009-07812, Consolider CSD2007-046, MAT2009-010350 and PROMETEO/2010/043.Springer Verlag (Germany)Instituto Universitario Mixto de Tecnología QuímicaGeneralitat ValencianaRepositorio Institucional de la Universitat Politècnica de València Riunet20112011-10-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://riunet.upv.es/handle/10251/84338reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valénciainstname:Universitat Politècnica de València (UPV)InglésengMinisterio de Ciencia e Innovación http://dx.doi.org/10.13039/501100004837 FIS2009-07812 Coloides De Silicio. Sintesis, Caracterizacion Y Aplicaciones Tecnologicas.Generalitat Valenciana https://doi.org/10.13039/501100003359 PROMETEO%2F2010%2F043 TRANSMISIÓN Y LOCALIZACIÓN DE ONDAS EN METAMATERIALESMinisterio de Educación y Ciencia https://doi.org/10.13039/501100008743 CSD2007-00046 NanoLight.es - Light Control on the NanoscaleMinisterio de Ciencia e Innovación http://dx.doi.org/10.13039/501100004837 MAT2009-10350 Confinamiento Y Efectos De Superficie En Heteroestructuras De Nanohilos Semiconducores Axiales Y Radiales: Del Agregado Al Nanohilo Individualopen accesshttp://purl.org/coar/access_right/c_abf2Reserva de todos los derechoshttp://rightsstatements.org/vocab/InC/1.0/info:eu-repo/semantics/openAccessoai:riunet.upv.es:10251/843382026-06-13T07:49:27Z
dc.title.none.fl_str_mv Medically Biodegradable Hydrogenated Amorphous Silicon Microspheres
title Medically Biodegradable Hydrogenated Amorphous Silicon Microspheres
spellingShingle Medically Biodegradable Hydrogenated Amorphous Silicon Microspheres
Shabir, Q.
Silicon
Amorphous.
Biodegradable
Medical
title_short Medically Biodegradable Hydrogenated Amorphous Silicon Microspheres
title_full Medically Biodegradable Hydrogenated Amorphous Silicon Microspheres
title_fullStr Medically Biodegradable Hydrogenated Amorphous Silicon Microspheres
title_full_unstemmed Medically Biodegradable Hydrogenated Amorphous Silicon Microspheres
title_sort Medically Biodegradable Hydrogenated Amorphous Silicon Microspheres
dc.creator.none.fl_str_mv Shabir, Q.
Pokale, A.
Loni, A.
Johnson, D. R.
Canham, L.T.
Tymczenko, Michal Konrad
Rodríguez, Marie-Isabelle
Cros, Ana
Cantarero, Andrés
Fenollosa Esteve, Roberto|||0000-0003-2758-9823
MESEGUER RICO, FRANCISCO JAVIER|||0000-0002-5541-9912
author Shabir, Q.
author_facet Shabir, Q.
Pokale, A.
Loni, A.
Johnson, D. R.
Canham, L.T.
Tymczenko, Michal Konrad
Rodríguez, Marie-Isabelle
Cros, Ana
Cantarero, Andrés
Fenollosa Esteve, Roberto|||0000-0003-2758-9823
MESEGUER RICO, FRANCISCO JAVIER|||0000-0002-5541-9912
author_role author
author2 Pokale, A.
Loni, A.
Johnson, D. R.
Canham, L.T.
Tymczenko, Michal Konrad
Rodríguez, Marie-Isabelle
Cros, Ana
Cantarero, Andrés
Fenollosa Esteve, Roberto|||0000-0003-2758-9823
MESEGUER RICO, FRANCISCO JAVIER|||0000-0002-5541-9912
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Instituto Universitario Mixto de Tecnología Química
Generalitat Valenciana
Repositorio Institucional de la Universitat Politècnica de València Riunet
dc.subject.none.fl_str_mv Silicon
Amorphous.
Biodegradable
Medical
topic Silicon
Amorphous.
Biodegradable
Medical
description [EN] Hydrogenated amorphous silicon colloids of low surface area (<5 m(2)/g) are shown to exhibit complete in-vitro biodegradation into orthosilicic acid within 10-15 days at 37 degrees C. When converted into polycrystalline silicon colloids, by high temperature annealing in an inert atmosphere, microparticle solubility is dramatically reduced. The data suggests that amorphous silicon does not require nanoscale porosification for full in-vivo biodegradability. This has significant implications for using a-Si:H coatings for medical implants in general, and orthopedic implants in particular. The high sphericity and biodegradability of submicron particles may also confer advantages with regards to contrast agents for medical imaging.
publishDate 2011
dc.date.none.fl_str_mv 2011
2011-10-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://riunet.upv.es/handle/10251/84338
url https://riunet.upv.es/handle/10251/84338
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Ciencia e Innovación http://dx.doi.org/10.13039/501100004837 FIS2009-07812 Coloides De Silicio. Sintesis, Caracterizacion Y Aplicaciones Tecnologicas.
Generalitat Valenciana https://doi.org/10.13039/501100003359 PROMETEO%2F2010%2F043 TRANSMISIÓN Y LOCALIZACIÓN DE ONDAS EN METAMATERIALES
Ministerio de Educación y Ciencia https://doi.org/10.13039/501100008743 CSD2007-00046 NanoLight.es - Light Control on the Nanoscale
Ministerio de Ciencia e Innovación http://dx.doi.org/10.13039/501100004837 MAT2009-10350 Confinamiento Y Efectos De Superficie En Heteroestructuras De Nanohilos Semiconducores Axiales Y Radiales: Del Agregado Al Nanohilo Individual
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reserva de todos los derechos
http://rightsstatements.org/vocab/InC/1.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reserva de todos los derechos
http://rightsstatements.org/vocab/InC/1.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer Verlag (Germany)
publisher.none.fl_str_mv Springer Verlag (Germany)
dc.source.none.fl_str_mv reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname:Universitat Politècnica de València (UPV)
instname_str Universitat Politècnica de València (UPV)
reponame_str RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
collection RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869420959257067520
score 15,300724

Similares en LA Referencia