Neuropsychiatric profiles and conversion to dementia in mild cognitive impairment, a latent class analysis

Roberto Herrero, Natalia|||0000-0002-5391-2711; Portella Moll, Maria J., 1975-|||0000-0002-2007-9516; Marquié, Marta|||0000-0002-0660-0950; Alegret, Montserrat|||0000-0002-8164-9500; Hernández, Isabel|||0000-0001-8119-393X; Mauleón, Ana|||0000-0002-4218-2127; Rosende-Roca, Maitée|||0000-0003-1778-8175; Abdelnour, Carla|||0000-0002-7636-9758; Esteban de Antonio, Ester|||0000-0003-1965-6010; Gil-Navarro, Silvia|||0000-0001-9921-9042; Tartari, Juan P.; Vargas, Liliana|||0000-0001-5685-5903; Espinosa, Ana|||0000-0001-7399-3267; Ortega Linares, Gemma|||0000-0002-7479-4072; Pérez-Cordón, Alba|||0000-0002-6028-0791; Sanabria, Ángela|||0000-0002-7501-9895; Orellana del Río, Adelina|||0000-0002-0204-1944; De Rojas, Itziar|||0000-0002-2148-381X; Moreno-Grau, Sonia; Montrreal Navarro, Laura|||0000-0002-0010-645X; Alarcón-Martín, Emilio|||0000-0002-0985-872X; Ruiz Laza, Agustín|||0000-0003-2633-2495; Tárraga, Lluís|||0000-0002-8423-946X; Boada, Mercè|||0000-0003-2617-3009; Valero, Sergi|||0000-0002-6599-948X

Neuropsychiatric profiles and conversion to dementia in mild cognitive impairment, a latent class analysis

Neuropsychiatric symptoms (NPS) have been recently addressed as risk factors of conversion to Alzheimer's disease (AD) and other dementia types in patients diagnosed with Mild Cognitive Impairment (MCI). Our aim was to determine profiles based on the prominent NPS in MCI patients and to explore...

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Autores:	Roberto Herrero, Natalia\|\|\|0000-0002-5391-2711, Portella Moll, Maria J., 1975-\|\|\|0000-0002-2007-9516, Marquié, Marta\|\|\|0000-0002-0660-0950, Alegret, Montserrat\|\|\|0000-0002-8164-9500, Hernández, Isabel\|\|\|0000-0001-8119-393X, Mauleón, Ana\|\|\|0000-0002-4218-2127, Rosende-Roca, Maitée\|\|\|0000-0003-1778-8175, Abdelnour, Carla\|\|\|0000-0002-7636-9758, Esteban de Antonio, Ester\|\|\|0000-0003-1965-6010, Gil-Navarro, Silvia\|\|\|0000-0001-9921-9042, Tartari, Juan P., Vargas, Liliana\|\|\|0000-0001-5685-5903, Espinosa, Ana\|\|\|0000-0001-7399-3267, Ortega Linares, Gemma\|\|\|0000-0002-7479-4072, Pérez-Cordón, Alba\|\|\|0000-0002-6028-0791, Sanabria, Ángela\|\|\|0000-0002-7501-9895, Orellana del Río, Adelina\|\|\|0000-0002-0204-1944, De Rojas, Itziar\|\|\|0000-0002-2148-381X, Moreno-Grau, Sonia, Montrreal Navarro, Laura\|\|\|0000-0002-0010-645X, Alarcón-Martín, Emilio\|\|\|0000-0002-0985-872X, Ruiz Laza, Agustín\|\|\|0000-0003-2633-2495, Tárraga, Lluís\|\|\|0000-0002-8423-946X, Boada, Mercè\|\|\|0000-0003-2617-3009, Valero, Sergi\|\|\|0000-0002-6599-948X
Tipo de recurso:	artículo
Fecha de publicación:	2021
País:	España
Institución:	Universitat Autònoma de Barcelona
Repositorio:	Dipòsit Digital de Documents de la UAB
Idioma:	inglés
OAI Identifier:	oai:ddd.uab.cat:255367
Acceso en línea:	https://ddd.uab.cat/record/255367 https://dx.doi.org/urn:doi:10.1038/s41598-021-83126-y
Access Level:	acceso abierto
Palabra clave:	Cognitive ageing Neuroscience Psychology Risk factors Signs and symptoms Neurology Dementia Neurodegenerative diseases

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spelling	Neuropsychiatric profiles and conversion to dementia in mild cognitive impairment, a latent class analysisRoberto Herrero, Natalia\|\|\|0000-0002-5391-2711Portella Moll, Maria J., 1975-\|\|\|0000-0002-2007-9516Marquié, Marta\|\|\|0000-0002-0660-0950Alegret, Montserrat\|\|\|0000-0002-8164-9500Hernández, Isabel\|\|\|0000-0001-8119-393XMauleón, Ana\|\|\|0000-0002-4218-2127Rosende-Roca, Maitée\|\|\|0000-0003-1778-8175Abdelnour, Carla\|\|\|0000-0002-7636-9758Esteban de Antonio, Ester\|\|\|0000-0003-1965-6010Gil-Navarro, Silvia\|\|\|0000-0001-9921-9042Tartari, Juan P.Vargas, Liliana\|\|\|0000-0001-5685-5903Espinosa, Ana\|\|\|0000-0001-7399-3267Ortega Linares, Gemma\|\|\|0000-0002-7479-4072Pérez-Cordón, Alba\|\|\|0000-0002-6028-0791Sanabria, Ángela\|\|\|0000-0002-7501-9895Orellana del Río, Adelina\|\|\|0000-0002-0204-1944De Rojas, Itziar\|\|\|0000-0002-2148-381XMoreno-Grau, SoniaMontrreal Navarro, Laura\|\|\|0000-0002-0010-645XAlarcón-Martín, Emilio\|\|\|0000-0002-0985-872XRuiz Laza, Agustín\|\|\|0000-0003-2633-2495Tárraga, Lluís\|\|\|0000-0002-8423-946XBoada, Mercè\|\|\|0000-0003-2617-3009Valero, Sergi\|\|\|0000-0002-6599-948XCognitive ageingNeurosciencePsychologyRisk factorsSigns and symptomsNeurologyDementiaNeurodegenerative diseasesNeuropsychiatric symptoms (NPS) have been recently addressed as risk factors of conversion to Alzheimer's disease (AD) and other dementia types in patients diagnosed with Mild Cognitive Impairment (MCI). Our aim was to determine profiles based on the prominent NPS in MCI patients and to explore the predictive value of these profiles on conversion to specific types of dementia. A total of 2137 MCI patients monitored in a memory clinic were included in the study. Four NPS profiles emerged (classes), which were defined by preeminent symptoms: Irritability, Apathy, Anxiety/Depression and Asymptomatic. Irritability and Apathy were predictors of conversion to dementia (HR = 1.43 and 1.56, respectively). Anxiety/depression class showed no risk effect of conversion when compared to Asymptomatic class. Irritability class appeared as the most discriminant neuropsychiatric condition to identify non-AD converters (i.e., frontotemporal dementia, vascular dementia, Parkinson's disease and dementia with Lewy Bodies). The findings revealed that consistent subgroups of MCI patients could be identified among comorbid basal NPS. The preeminent NPS showed to behave differentially on conversion to dementia, beyond AD. Therefore, NPS should be used as early diagnosis facilitators, and should also guide clinicians to detect patients with different illness trajectories in the progression of MCI.Universitat Autònoma de Barcelona 22021-01-0120212021-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/255367https://dx.doi.org/urn:doi:10.1038/s41598-021-83126-yreponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengInstituto de Salud Carlos III https://doi.org/10.13039/501100004587 CPII16-0020Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI13/02434Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI16/01861Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 BA19/00020Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI19/01301European Commission https://doi.org/10.13039/501100000780 796706European Commission https://doi.org/10.13039/501100000780 115975open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2553672026-06-06T12:50:31Z
dc.title.none.fl_str_mv	Neuropsychiatric profiles and conversion to dementia in mild cognitive impairment, a latent class analysis
title	Neuropsychiatric profiles and conversion to dementia in mild cognitive impairment, a latent class analysis
spellingShingle	Neuropsychiatric profiles and conversion to dementia in mild cognitive impairment, a latent class analysis Roberto Herrero, Natalia\|\|\|0000-0002-5391-2711 Cognitive ageing Neuroscience Psychology Risk factors Signs and symptoms Neurology Dementia Neurodegenerative diseases
title_short	Neuropsychiatric profiles and conversion to dementia in mild cognitive impairment, a latent class analysis
title_full	Neuropsychiatric profiles and conversion to dementia in mild cognitive impairment, a latent class analysis
title_fullStr	Neuropsychiatric profiles and conversion to dementia in mild cognitive impairment, a latent class analysis
title_full_unstemmed	Neuropsychiatric profiles and conversion to dementia in mild cognitive impairment, a latent class analysis
title_sort	Neuropsychiatric profiles and conversion to dementia in mild cognitive impairment, a latent class analysis
dc.creator.none.fl_str_mv	Roberto Herrero, Natalia\|\|\|0000-0002-5391-2711 Portella Moll, Maria J., 1975-\|\|\|0000-0002-2007-9516 Marquié, Marta\|\|\|0000-0002-0660-0950 Alegret, Montserrat\|\|\|0000-0002-8164-9500 Hernández, Isabel\|\|\|0000-0001-8119-393X Mauleón, Ana\|\|\|0000-0002-4218-2127 Rosende-Roca, Maitée\|\|\|0000-0003-1778-8175 Abdelnour, Carla\|\|\|0000-0002-7636-9758 Esteban de Antonio, Ester\|\|\|0000-0003-1965-6010 Gil-Navarro, Silvia\|\|\|0000-0001-9921-9042 Tartari, Juan P. Vargas, Liliana\|\|\|0000-0001-5685-5903 Espinosa, Ana\|\|\|0000-0001-7399-3267 Ortega Linares, Gemma\|\|\|0000-0002-7479-4072 Pérez-Cordón, Alba\|\|\|0000-0002-6028-0791 Sanabria, Ángela\|\|\|0000-0002-7501-9895 Orellana del Río, Adelina\|\|\|0000-0002-0204-1944 De Rojas, Itziar\|\|\|0000-0002-2148-381X Moreno-Grau, Sonia Montrreal Navarro, Laura\|\|\|0000-0002-0010-645X Alarcón-Martín, Emilio\|\|\|0000-0002-0985-872X Ruiz Laza, Agustín\|\|\|0000-0003-2633-2495 Tárraga, Lluís\|\|\|0000-0002-8423-946X Boada, Mercè\|\|\|0000-0003-2617-3009 Valero, Sergi\|\|\|0000-0002-6599-948X
author	Roberto Herrero, Natalia\|\|\|0000-0002-5391-2711
author_facet	Roberto Herrero, Natalia\|\|\|0000-0002-5391-2711 Portella Moll, Maria J., 1975-\|\|\|0000-0002-2007-9516 Marquié, Marta\|\|\|0000-0002-0660-0950 Alegret, Montserrat\|\|\|0000-0002-8164-9500 Hernández, Isabel\|\|\|0000-0001-8119-393X Mauleón, Ana\|\|\|0000-0002-4218-2127 Rosende-Roca, Maitée\|\|\|0000-0003-1778-8175 Abdelnour, Carla\|\|\|0000-0002-7636-9758 Esteban de Antonio, Ester\|\|\|0000-0003-1965-6010 Gil-Navarro, Silvia\|\|\|0000-0001-9921-9042 Tartari, Juan P. Vargas, Liliana\|\|\|0000-0001-5685-5903 Espinosa, Ana\|\|\|0000-0001-7399-3267 Ortega Linares, Gemma\|\|\|0000-0002-7479-4072 Pérez-Cordón, Alba\|\|\|0000-0002-6028-0791 Sanabria, Ángela\|\|\|0000-0002-7501-9895 Orellana del Río, Adelina\|\|\|0000-0002-0204-1944 De Rojas, Itziar\|\|\|0000-0002-2148-381X Moreno-Grau, Sonia Montrreal Navarro, Laura\|\|\|0000-0002-0010-645X Alarcón-Martín, Emilio\|\|\|0000-0002-0985-872X Ruiz Laza, Agustín\|\|\|0000-0003-2633-2495 Tárraga, Lluís\|\|\|0000-0002-8423-946X Boada, Mercè\|\|\|0000-0003-2617-3009 Valero, Sergi\|\|\|0000-0002-6599-948X
author_role	author
author2	Portella Moll, Maria J., 1975-\|\|\|0000-0002-2007-9516 Marquié, Marta\|\|\|0000-0002-0660-0950 Alegret, Montserrat\|\|\|0000-0002-8164-9500 Hernández, Isabel\|\|\|0000-0001-8119-393X Mauleón, Ana\|\|\|0000-0002-4218-2127 Rosende-Roca, Maitée\|\|\|0000-0003-1778-8175 Abdelnour, Carla\|\|\|0000-0002-7636-9758 Esteban de Antonio, Ester\|\|\|0000-0003-1965-6010 Gil-Navarro, Silvia\|\|\|0000-0001-9921-9042 Tartari, Juan P. Vargas, Liliana\|\|\|0000-0001-5685-5903 Espinosa, Ana\|\|\|0000-0001-7399-3267 Ortega Linares, Gemma\|\|\|0000-0002-7479-4072 Pérez-Cordón, Alba\|\|\|0000-0002-6028-0791 Sanabria, Ángela\|\|\|0000-0002-7501-9895 Orellana del Río, Adelina\|\|\|0000-0002-0204-1944 De Rojas, Itziar\|\|\|0000-0002-2148-381X Moreno-Grau, Sonia Montrreal Navarro, Laura\|\|\|0000-0002-0010-645X Alarcón-Martín, Emilio\|\|\|0000-0002-0985-872X Ruiz Laza, Agustín\|\|\|0000-0003-2633-2495 Tárraga, Lluís\|\|\|0000-0002-8423-946X Boada, Mercè\|\|\|0000-0003-2617-3009 Valero, Sergi\|\|\|0000-0002-6599-948X
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv	Cognitive ageing Neuroscience Psychology Risk factors Signs and symptoms Neurology Dementia Neurodegenerative diseases
topic	Cognitive ageing Neuroscience Psychology Risk factors Signs and symptoms Neurology Dementia Neurodegenerative diseases
description	Neuropsychiatric symptoms (NPS) have been recently addressed as risk factors of conversion to Alzheimer's disease (AD) and other dementia types in patients diagnosed with Mild Cognitive Impairment (MCI). Our aim was to determine profiles based on the prominent NPS in MCI patients and to explore the predictive value of these profiles on conversion to specific types of dementia. A total of 2137 MCI patients monitored in a memory clinic were included in the study. Four NPS profiles emerged (classes), which were defined by preeminent symptoms: Irritability, Apathy, Anxiety/Depression and Asymptomatic. Irritability and Apathy were predictors of conversion to dementia (HR = 1.43 and 1.56, respectively). Anxiety/depression class showed no risk effect of conversion when compared to Asymptomatic class. Irritability class appeared as the most discriminant neuropsychiatric condition to identify non-AD converters (i.e., frontotemporal dementia, vascular dementia, Parkinson's disease and dementia with Lewy Bodies). The findings revealed that consistent subgroups of MCI patients could be identified among comorbid basal NPS. The preeminent NPS showed to behave differentially on conversion to dementia, beyond AD. Therefore, NPS should be used as early diagnosis facilitators, and should also guide clinicians to detect patients with different illness trajectories in the progression of MCI.
publishDate	2021
dc.date.none.fl_str_mv	2 2021-01-01 2021 2021-01-01
dc.type.none.fl_str_mv	Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://ddd.uab.cat/record/255367 https://dx.doi.org/urn:doi:10.1038/s41598-021-83126-y
url	https://ddd.uab.cat/record/255367 https://dx.doi.org/urn:doi:10.1038/s41598-021-83126-y
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.relation.none.fl_str_mv	Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 CPII16-0020 Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI13/02434 Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI16/01861 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 BA19/00020 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI19/01301 European Commission https://doi.org/10.13039/501100000780 796706 European Commission https://doi.org/10.13039/501100000780 115975
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.source.none.fl_str_mv	reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona
instname_str	Universitat Autònoma de Barcelona
reponame_str	Dipòsit Digital de Documents de la UAB
collection	Dipòsit Digital de Documents de la UAB
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repository.mail.fl_str_mv
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Neuropsychiatric profiles and conversion to dementia in mild cognitive impairment, a latent class analysis

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