Neuropsychiatric Profile as a Predictor of Cognitive Decline in Mild Cognitive Impairment

Introduction: Mild cognitive impairment is often associated with affective and other neuropsychiatric symptoms (NPS). This co-occurrence might have a relevant impact on disease progression, from MCI to dementia. Objective: The aim of this study was to explore the trajectories of cognitive decline in...

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Detalles Bibliográficos
Autores: Roberto Herrero, Natalia|||0000-0002-5391-2711, Portella Moll, Maria J., 1975-|||0000-0002-2007-9516, Marquié, Marta|||0000-0002-0660-0950, Alegret, Montserrat|||0000-0002-8164-9500, Hernández, Isabel|||0000-0001-8119-393X, Mauleón, Ana|||0000-0002-4218-2127, Rosende-Roca, Maitée|||0000-0003-1778-8175, Abdelnour, Carla|||0000-0002-7636-9758, Esteban de Antonio, Ester|||0000-0003-1965-6010, Tartari, Juan P., Vargas, Liliana|||0000-0001-5685-5903, López-Cuevas, Rogelio, Bojaryn, Urszula, Espinosa, Ana|||0000-0001-7399-3267, Ortega Linares, Gemma|||0000-0002-7479-4072, Pérez-Cordón, Alba|||0000-0002-6028-0791, Sanabria, Ángela|||0000-0002-7501-9895, Orellana del Río, Adelina|||0000-0002-0204-1944, De Rojas, Itziar|||0000-0002-2148-381X, Moreno-Grau, Sonia, Montrreal Navarro, Laura|||0000-0002-0010-645X, Alarcón-Martín, Emilio|||0000-0002-0985-872X, Ruiz Laza, Agustín|||0000-0003-2633-2495, Tárraga, Lluís|||0000-0002-8423-946X, Boada, Mercè|||0000-0003-2617-3009, Valero, Sergi|||0000-0002-6599-948X
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:264459
Acceso en línea:https://ddd.uab.cat/record/264459
https://dx.doi.org/urn:doi:10.3389/fnagi.2021.718949
Access Level:acceso abierto
Palabra clave:Anxiety
Apathy
Cognitive decline
Depression
Irritability
Mild cognitive impairment
Neuropsychiatric symptoms
Descripción
Sumario:Introduction: Mild cognitive impairment is often associated with affective and other neuropsychiatric symptoms (NPS). This co-occurrence might have a relevant impact on disease progression, from MCI to dementia. Objective: The aim of this study was to explore the trajectories of cognitive decline in an MCI sample from a memory clinic, taking into consideration a perspective of isolated cognitive functions and based on NPS clusters, accounting for the different comorbid symptoms collected at their baseline visit. Methods: A total of 2,137 MCI patients were monitored over a 2.4-year period. Four clusters of NPS (i.e., Irritability, Apathy, Anxiety/Depression and Asymptomatic) were used to run linear mixed models to explore the interaction of cluster with time on cognitive trajectories using a comprehensive neuropsychological battery (NBACE) administered at baseline and at the three subsequent follow-ups. Results: A significant interaction between cluster and time in cognitive decline was found when verbal learning and cued-recall were explored (p = 0.002 for both memory functions). For verbal learning, the Irritability cluster had the largest effect size (0.69), whereas the Asymptomatic cluster showed the smallest effect size (0.22). For cued-recall, the Irritability cluster had the largest effect size among groups (0.64), and Anxiety/Depression had the smallest effect size (0.21). Conclusions: In MCI patients, the Irritability and Apathy NPS clusters shared similar patterns of worsening in memory functioning, which could point to these NPS as risk factors of a faster cognitive decline, acting as early prognostic markers and helping in the diagnostic process.

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