Neuropsychiatric profiles and conversion to dementia in mild cognitive impairment, a latent class analysis

Neuropsychiatric symptoms (NPS) have been recently addressed as risk factors of conversion to Alzheimer's disease (AD) and other dementia types in patients diagnosed with Mild Cognitive Impairment (MCI). Our aim was to determine profiles based on the prominent NPS in MCI patients and to explore...

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Detalles Bibliográficos
Autores: Roberto Herrero, Natalia|||0000-0002-5391-2711, Portella Moll, Maria J., 1975-|||0000-0002-2007-9516, Marquié, Marta|||0000-0002-0660-0950, Alegret, Montserrat|||0000-0002-8164-9500, Hernández, Isabel|||0000-0001-8119-393X, Mauleón, Ana|||0000-0002-4218-2127, Rosende-Roca, Maitée|||0000-0003-1778-8175, Abdelnour, Carla|||0000-0002-7636-9758, Esteban de Antonio, Ester|||0000-0003-1965-6010, Gil-Navarro, Silvia|||0000-0001-9921-9042, Tartari, Juan P., Vargas, Liliana|||0000-0001-5685-5903, Espinosa, Ana|||0000-0001-7399-3267, Ortega Linares, Gemma|||0000-0002-7479-4072, Pérez-Cordón, Alba|||0000-0002-6028-0791, Sanabria, Ángela|||0000-0002-7501-9895, Orellana del Río, Adelina|||0000-0002-0204-1944, De Rojas, Itziar|||0000-0002-2148-381X, Moreno-Grau, Sonia, Montrreal Navarro, Laura|||0000-0002-0010-645X, Alarcón-Martín, Emilio|||0000-0002-0985-872X, Ruiz Laza, Agustín|||0000-0003-2633-2495, Tárraga, Lluís|||0000-0002-8423-946X, Boada, Mercè|||0000-0003-2617-3009, Valero, Sergi|||0000-0002-6599-948X
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:255367
Acceso en línea:https://ddd.uab.cat/record/255367
https://dx.doi.org/urn:doi:10.1038/s41598-021-83126-y
Access Level:acceso abierto
Palabra clave:Cognitive ageing
Neuroscience
Psychology
Risk factors
Signs and symptoms
Neurology
Dementia
Neurodegenerative diseases
Descripción
Sumario:Neuropsychiatric symptoms (NPS) have been recently addressed as risk factors of conversion to Alzheimer's disease (AD) and other dementia types in patients diagnosed with Mild Cognitive Impairment (MCI). Our aim was to determine profiles based on the prominent NPS in MCI patients and to explore the predictive value of these profiles on conversion to specific types of dementia. A total of 2137 MCI patients monitored in a memory clinic were included in the study. Four NPS profiles emerged (classes), which were defined by preeminent symptoms: Irritability, Apathy, Anxiety/Depression and Asymptomatic. Irritability and Apathy were predictors of conversion to dementia (HR = 1.43 and 1.56, respectively). Anxiety/depression class showed no risk effect of conversion when compared to Asymptomatic class. Irritability class appeared as the most discriminant neuropsychiatric condition to identify non-AD converters (i.e., frontotemporal dementia, vascular dementia, Parkinson's disease and dementia with Lewy Bodies). The findings revealed that consistent subgroups of MCI patients could be identified among comorbid basal NPS. The preeminent NPS showed to behave differentially on conversion to dementia, beyond AD. Therefore, NPS should be used as early diagnosis facilitators, and should also guide clinicians to detect patients with different illness trajectories in the progression of MCI.

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