Incidence and prognosis of colorectal cancer after heart transplantation: data from the Spanish Post-Heart Transplant Tumor Registry

In this observational and multicenter study, that included all patients who underwent a heart transplantation (HT) in Spain from 1984 to 2018, we analyzed the incidence, management, and prognosis of colorectal cancer (CRC) after HT. Of 6,244 patients with a HT and a median follow-up of 8.8 years sin...

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Autores: Sagastagoitia-Fornie, M. (Marta)|||/items/e16f1195-34ee-40ef-8869-f5f529b6b644, Morán, L. (Laura)|||/items/49f32dd3-11ac-4cb8-8d32-7b947e92392e, Blázquez-Bermejo, Z. (Zorba)|||/items/b6109d7e-1922-4f83-9f1d-e10922bfe57b, Díaz-Molina, B. (Beatriz)|||/items/9890606d-1ced-4170-8a08-940b15711896, Gómez, M. (Manuel)|||/items/a1bd4797-b9fa-4b84-86a7-8ac366c09361, Almenar-Bonet, L. (Luis)|||/items/6765048f-6853-4171-a4b5-8f7716363496, López-Granados, A. (Amador)|||/items/9a23ef10-e287-4889-8644-ff1e0b5021fa, González-Vílchez, F. (Francisco)|||/items/249a0d79-0ff3-4ba7-a883-821f7768714f, Mirabet-Pérez, S. (Sonia)|||/items/15e70d7f-6876-49e4-abac-283869182f71, García-Romero, E. (Elena)|||/items/f69c951f-35ea-4372-b40f-435f3d003013, Sobrino-Márquez, J.M. (Jose M.)|||/items/9e5ed089-3c9d-4c0c-9a3d-0b8ba5156970, Rabago, G. (Gregorio)|||/items/80ea8921-99e9-46db-b2f0-5bf236e53534, Castel-Lavilla, M.A. (Maria Angels)|||/items/68e6f321-81c9-4d5a-b70c-1ac945e11436, Blasco-Peiro, T. (Teresa)|||/items/fa72c1ed-841f-4ec4-a899-dc8896e9cb89, Garrido-Bravo, I. (Iris)|||/items/f99f6b0d-34a8-4e39-a63e-cab053759ab4, Fuente-Galán, L. (Luis) de la|||/items/f781b2f3-d500-4136-ad24-d88a655d72ea, Muñiz, J. (Javier)|||/items/60f6652b-7953-4242-8be0-fdfc9fd54559, Crespo-Leiro, M.G. (María G.)|||/items/3e705363-dd05-4837-9ae7-ff8d8c21b34d
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/67271
Acceso en línea:https://hdl.handle.net/10171/67271
Access Level:acceso abierto
Palabra clave:Heart transplantation
Prognosis
Incidence
Colorectal cancer
Management
Descripción
Sumario:In this observational and multicenter study, that included all patients who underwent a heart transplantation (HT) in Spain from 1984 to 2018, we analyzed the incidence, management, and prognosis of colorectal cancer (CRC) after HT. Of 6,244 patients with a HT and a median follow-up of 8.8 years since the procedure, 116 CRC cases (11.5% of noncutaneous solid cancers other than lymphoma registered) were diagnosed, mainly adenocarcinomas, after a mean of 9.3 years post-HT. The incidence of CRC increased with age at HT from 56.6 per 100,000 person-years among under 45 year olds to 436.4 per 100,000 person-years among over 64 year olds. The incidence rates for age-at-diagnosis groups were significantly greater than those estimated for the general Spanish population. Curative surgery, performed for 62 of 74 operable tumors, increased the probability of patient survival since a diagnosis of CRC, from 31.6% to 75.7% at 2 years, and from 15.8% to 48.6% at 5 years, compared to patients with inoperable tumors. Our results suggest that the incidence of CRC among HT patients is greater than in the general population, increasing with age at HT.

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