Incidence and Prognosis of Colorectal Cancer After Heart Transplantation: Data From the Spanish Post-Heart Transplant Tumor Registry

In this observational and multicenter study, that included all patients who underwent a heart transplantation (HT) in Spain from 1984 to 2018, we analyzed the incidence, management, and prognosis of colorectal cancer (CRC) after HT. Of 6,244 patients with a HT and a median follow-up of 8.8 years sin...

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Detalhes bibliográficos
Autores: Sagastagoitia-Fornie M., Morán-Fernández L., Blázquez-Bermejo Z., Díaz-Molina B., Gómez-Bueno M., Almenar-Bonet L., López-Granados A., González-Vílchez F., Mirabet-Pérez S., García-Romero E., Jose, MSM, Juan-Aracil, GR, Castel-Lavilla M.A., Blasco-Peiro T., Garrido-Bravo I., De La Fuente-Galán L., Muniz, J, Crespo-Leiro M.G.
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Recursos:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p16293
Acesso em linha:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=16293
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85160984904&doi=10.3389%2fti.2023.11042&partnerID=40&md5=a1d3e234e1b65aeea83d78c9ecc94436
Access Level:acceso abierto
Palavra-chave:heart transplantation
prognosis
incidence
colorectal cancer
management
Descrição
Resumo:In this observational and multicenter study, that included all patients who underwent a heart transplantation (HT) in Spain from 1984 to 2018, we analyzed the incidence, management, and prognosis of colorectal cancer (CRC) after HT. Of 6,244 patients with a HT and a median follow-up of 8.8 years since the procedure, 116 CRC cases (11.5% of noncutaneous solid cancers other than lymphoma registered) were diagnosed, mainly adenocarcinomas, after a mean of 9.3 years post-HT. The incidence of CRC increased with age at HT from 56.6 per 100,000 person-years among under 45 year olds to 436.4 per 100,000 person-years among over 64 year olds. The incidence rates for age-at-diagnosis groups were significantly greater than those estimated for the general Spanish population. Curative surgery, performed for 62 of 74 operable tumors, increased the probability of patient survival since a diagnosis of CRC, from 31.6% to 75.7% at 2 years, and from 15.8% to 48.6% at 5 years, compared to patients with inoperable tumors. Our results suggest that the incidence of CRC among HT patients is greater than in the general population, increasing with age at HT.

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