Incidence and Prognosis of Colorectal Cancer After Heart Transplantation: Data From the Spanish Post-Heart Transplant Tumor Registry

In this observational and multicenter study, that included all patients who underwent a heart transplantation (HT) in Spain from 1984 to 2018, we analyzed the incidence, management, and prognosis of colorectal cancer (CRC) after HT. Of 6,244 patients with a HT and a median follow-up of 8.8 years sin...

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Detalles Bibliográficos
Autores: Sagastagoitia Fornie, Marta, Morán-Fernández, L., Blázquez-Bermejo, Z., Díaz-Molina, B., Gómez-Bueno, M., Almenar-Bonet, L., López-Granados, A., González-Vílchez, F., Mirabet-Pérez, S., García-Romero, E., Jose M, S.-M., Rábago Juan-Aracil, G., Castel-Lavilla, M.A., Blasco-Peiro, T., Garrido-Bravo, I., De La Fuente-Galán, L., Muñiz García, Javier, Crespo Leiro, Marisa
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Servizo Galego de Saúde (SERGAS)
Repositorio:RUNA. Repositorio da Consellería de Sanidade e Sergas
OAI Identifier:oai:runa.sergas.gal:20.500.11940/21626
Acceso en línea:https://portalcientifico.sergas.gal//documentos/648fd78ef1a6cb24f859be65
http://hdl.handle.net/20.500.11940/21626
Access Level:acceso abierto
Palabra clave:Humans
Incidence
Heart Transplantation
Prognosis
Colorectal Neoplasms
Registries
Retrospective Studies
AS Ferrol
CHUF
AS A Coruña
INIBIC
CHUAC
Descripción
Sumario:In this observational and multicenter study, that included all patients who underwent a heart transplantation (HT) in Spain from 1984 to 2018, we analyzed the incidence, management, and prognosis of colorectal cancer (CRC) after HT. Of 6,244 patients with a HT and a median follow-up of 8.8 years since the procedure, 116 CRC cases (11.5% of noncutaneous solid cancers other than lymphoma registered) were diagnosed, mainly adenocarcinomas, after a mean of 9.3 years post-HT. The incidence of CRC increased with age at HT from 56.6 per 100,000 person-years among under 45 year olds to 436.4 per 100,000 person-years among over 64 year olds. The incidence rates for age-at-diagnosis groups were significantly greater than those estimated for the general Spanish population. Curative surgery, performed for 62 of 74 operable tumors, increased the probability of patient survival since a diagnosis of CRC, from 31.6% to 75.7% at 2 years, and from 15.8% to 48.6% at 5 years, compared to patients with inoperable tumors. Our results suggest that the incidence of CRC among HT patients is greater than in the general population, increasing with age at HT.

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