Recent Progress in Enzymatic Release of Peptides in Foods of Animal Origin and Assessment of Bioactivity

This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Agricultural and Food Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://do...

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Detalhes bibliográficos
Autores: Toldrá Vilardell, Fidel, Gallego, Marta, Reig, Milagro, Aristoy, María Concepción, Mora, Leticia
Tipo de documento: artigo
Estado:Versión aceptada para publicación
Data de publicação:2020
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositório:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/226196
Acesso em linha:http://hdl.handle.net/10261/226196
Access Level:Acceso aberto
Palavra-chave:Proteolysis
Bioactive peptides
Proteomics
Mass spectrometry
Enzyme hydrolysis
Peptidases
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spelling Recent Progress in Enzymatic Release of Peptides in Foods of Animal Origin and Assessment of BioactivityToldrá Vilardell, FidelGallego, MartaReig, MilagroAristoy, María ConcepciónMora, LeticiaProteolysisBioactive peptidesProteomicsMass spectrometryEnzyme hydrolysisPeptidasesThis document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Agricultural and Food Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.jafc.9b08297There is a wide variety of peptides released from food proteins that are able to exert a relevant benefit for human health, such as angiotensin-converting enzyme inhibition, antioxidant, anti-inflammatory, hypoglucemic, or antithrombotic activity, among others. This manuscript is reviewing the recent advances on enzymatic mechanisms for the hydrolysis of proteins from foods of animal origin, including the types of enzymes and mechanisms of action involved, the strategies followed for the isolation and identification of bioactive peptides through advanced proteomic tools, and the assessment of bioactivity and its beneficial effects. Specific applications in fermented and/or ripened foods where a significant number of bioactive peptides have been reported with relevant in vivo physiological effects on laboratory rats and humans as well as the hydrolysis of animal food proteins for the production of bioactive peptides are also reviewed.The research leading to these results received funding from Grant AGL2017-89381-R from the Spanish Ministry of Economy, Industry and Competitivity and FEDER funds. Ramón y Cajal postdoctoral contract to Leticia Mora is also acknowledged.Peer reviewedAmerican Chemical SocietyMinisterio de Economía, Industria y Competitividad (España)European CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202120212020info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/226196reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2017-89381-Rhttps://doi.org/10.1021/acs.jafc.9b08297Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2261962026-05-22T06:33:51Z
dc.title.none.fl_str_mv Recent Progress in Enzymatic Release of Peptides in Foods of Animal Origin and Assessment of Bioactivity
title Recent Progress in Enzymatic Release of Peptides in Foods of Animal Origin and Assessment of Bioactivity
spellingShingle Recent Progress in Enzymatic Release of Peptides in Foods of Animal Origin and Assessment of Bioactivity
Toldrá Vilardell, Fidel
Proteolysis
Bioactive peptides
Proteomics
Mass spectrometry
Enzyme hydrolysis
Peptidases
title_short Recent Progress in Enzymatic Release of Peptides in Foods of Animal Origin and Assessment of Bioactivity
title_full Recent Progress in Enzymatic Release of Peptides in Foods of Animal Origin and Assessment of Bioactivity
title_fullStr Recent Progress in Enzymatic Release of Peptides in Foods of Animal Origin and Assessment of Bioactivity
title_full_unstemmed Recent Progress in Enzymatic Release of Peptides in Foods of Animal Origin and Assessment of Bioactivity
title_sort Recent Progress in Enzymatic Release of Peptides in Foods of Animal Origin and Assessment of Bioactivity
dc.creator.none.fl_str_mv Toldrá Vilardell, Fidel
Gallego, Marta
Reig, Milagro
Aristoy, María Concepción
Mora, Leticia
author Toldrá Vilardell, Fidel
author_facet Toldrá Vilardell, Fidel
Gallego, Marta
Reig, Milagro
Aristoy, María Concepción
Mora, Leticia
author_role author
author2 Gallego, Marta
Reig, Milagro
Aristoy, María Concepción
Mora, Leticia
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía, Industria y Competitividad (España)
European Commission
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Proteolysis
Bioactive peptides
Proteomics
Mass spectrometry
Enzyme hydrolysis
Peptidases
topic Proteolysis
Bioactive peptides
Proteomics
Mass spectrometry
Enzyme hydrolysis
Peptidases
description This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Agricultural and Food Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.jafc.9b08297
publishDate 2020
dc.date.none.fl_str_mv 2020
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/226196
url http://hdl.handle.net/10261/226196
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2017-89381-R
https://doi.org/10.1021/acs.jafc.9b08297
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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