Neuroprotective Effect of 3′,4′-Dihydroxyphenylglycol in Type-1-like Diabetic Rats—Influence of the Hydroxytyrosol/3′,4′-dihydroxyphenylglycol Ratio

13 Páginas.-- 3 Figuras.-- 3 Tablas

Detalles Bibliográficos
Autores: Rodríguez-Pérez, María Dolores, de Algaba, I.P., Martín-Aurioles, Esther, Arrebola, María Monsalud, Ortega-Hombrados, Laura, Verdugo, Cristina, Fernández-Prior, África, Bermúdez-Oria, Alejandra, Cruz, José Pedro de la, González-Correa, José Antonio
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/287343
Acceso en línea:http://hdl.handle.net/10261/287343
Access Level:acceso abierto
Palabra clave:Hydroxytyrosol
3′,4′-dihydroxyphenylglycol
Extra virgin olive oil
Diabetic neuropathy
Diabetes mellitus
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spelling Neuroprotective Effect of 3′,4′-Dihydroxyphenylglycol in Type-1-like Diabetic Rats—Influence of the Hydroxytyrosol/3′,4′-dihydroxyphenylglycol RatioRodríguez-Pérez, María Doloresde Algaba, I.P.Martín-Aurioles, EstherArrebola, María MonsaludOrtega-Hombrados, LauraVerdugo, CristinaFernández-Prior, ÁfricaBermúdez-Oria, AlejandraCruz, José Pedro de laGonzález-Correa, José AntonioHydroxytyrosol3′,4′-dihydroxyphenylglycolExtra virgin olive oilDiabetic neuropathyDiabetes mellitus13 Páginas.-- 3 Figuras.-- 3 TablasThe aim of this study was to assess the possible neuroprotective effect of 3,4-dihydroxyphe-nylglycol (DHPG), a polyphenol from extra virgin olive oil (EVOO), in an experimental model of diabetes and whether this effect is modified by the presence of another EVOO polyphenol, hydroxy-tyrosol (HT). The neuroprotective effect was assessed in a hypoxia–reoxygenation model in brain slices and by quantifying retinal nerve cells. The animals were distributed as follows: (1) normo-glycemic rats (NDR), (2) diabetic rats (DR), (3) DR treated with HT (5 mg/kg/day p.o.), (4) DR treated with DHPG (0.5 mg/kg/day), or (5) with 1 mg/kg/day, (6) DR treated with HT plus DHPG 0.5 mg/kg/day, or (7) HT plus 1 mg/kg/day p.o. DHPG. Diabetic animals presented higher levels of oxidative stress variables and lower numbers of neuronal cells in retinal tissue. The administration of DHPG or HT reduced most of the oxidative stress variables and brain lactate dehydrogenase efflux (LDH) as an indirect index of cellular death and also reduced the loss of retinal cells. The association of DHPG+HT in the same proportions, as found in EVOO, improved the neuroprotective and antioxidant effects of both polyphenols.This study was supported, in part, by the Consejería de Salud. Junta de Andalucía (Spain), Proyectos de Investigación en Salud [Regional Ministry of Health. Junta de Andalucía (Spain), Health Research Projects] (PI-0129-2017).Multidisciplinary Digital Publishing InstituteJunta de AndalucíaConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2023202320222023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/287343reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.3390/nu14061146Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2873432026-05-22T06:33:51Z
dc.title.none.fl_str_mv Neuroprotective Effect of 3′,4′-Dihydroxyphenylglycol in Type-1-like Diabetic Rats—Influence of the Hydroxytyrosol/3′,4′-dihydroxyphenylglycol Ratio
title Neuroprotective Effect of 3′,4′-Dihydroxyphenylglycol in Type-1-like Diabetic Rats—Influence of the Hydroxytyrosol/3′,4′-dihydroxyphenylglycol Ratio
spellingShingle Neuroprotective Effect of 3′,4′-Dihydroxyphenylglycol in Type-1-like Diabetic Rats—Influence of the Hydroxytyrosol/3′,4′-dihydroxyphenylglycol Ratio
Rodríguez-Pérez, María Dolores
Hydroxytyrosol
3′,4′-dihydroxyphenylglycol
Extra virgin olive oil
Diabetic neuropathy
Diabetes mellitus
title_short Neuroprotective Effect of 3′,4′-Dihydroxyphenylglycol in Type-1-like Diabetic Rats—Influence of the Hydroxytyrosol/3′,4′-dihydroxyphenylglycol Ratio
title_full Neuroprotective Effect of 3′,4′-Dihydroxyphenylglycol in Type-1-like Diabetic Rats—Influence of the Hydroxytyrosol/3′,4′-dihydroxyphenylglycol Ratio
title_fullStr Neuroprotective Effect of 3′,4′-Dihydroxyphenylglycol in Type-1-like Diabetic Rats—Influence of the Hydroxytyrosol/3′,4′-dihydroxyphenylglycol Ratio
title_full_unstemmed Neuroprotective Effect of 3′,4′-Dihydroxyphenylglycol in Type-1-like Diabetic Rats—Influence of the Hydroxytyrosol/3′,4′-dihydroxyphenylglycol Ratio
title_sort Neuroprotective Effect of 3′,4′-Dihydroxyphenylglycol in Type-1-like Diabetic Rats—Influence of the Hydroxytyrosol/3′,4′-dihydroxyphenylglycol Ratio
dc.creator.none.fl_str_mv Rodríguez-Pérez, María Dolores
de Algaba, I.P.
Martín-Aurioles, Esther
Arrebola, María Monsalud
Ortega-Hombrados, Laura
Verdugo, Cristina
Fernández-Prior, África
Bermúdez-Oria, Alejandra
Cruz, José Pedro de la
González-Correa, José Antonio
author Rodríguez-Pérez, María Dolores
author_facet Rodríguez-Pérez, María Dolores
de Algaba, I.P.
Martín-Aurioles, Esther
Arrebola, María Monsalud
Ortega-Hombrados, Laura
Verdugo, Cristina
Fernández-Prior, África
Bermúdez-Oria, Alejandra
Cruz, José Pedro de la
González-Correa, José Antonio
author_role author
author2 de Algaba, I.P.
Martín-Aurioles, Esther
Arrebola, María Monsalud
Ortega-Hombrados, Laura
Verdugo, Cristina
Fernández-Prior, África
Bermúdez-Oria, Alejandra
Cruz, José Pedro de la
González-Correa, José Antonio
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Junta de Andalucía
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Hydroxytyrosol
3′,4′-dihydroxyphenylglycol
Extra virgin olive oil
Diabetic neuropathy
Diabetes mellitus
topic Hydroxytyrosol
3′,4′-dihydroxyphenylglycol
Extra virgin olive oil
Diabetic neuropathy
Diabetes mellitus
description 13 Páginas.-- 3 Figuras.-- 3 Tablas
publishDate 2022
dc.date.none.fl_str_mv 2022
2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/287343
url http://hdl.handle.net/10261/287343
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.3390/nu14061146
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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