In Vitro Digestibility and Bioaccessibility of Nutrients and Non-Nutrients Composing Extruded Brewers’ Spent Grain

This is a reprint of the Special Issue, published open access by the journal Nutrients (ISSN 2072-6643), freely accessible at: https://www.mdpi.com/journal/nutrients/special issues/bioactive oxidative.

Detalles Bibliográficos
Autores: Gutiérrez-Barrutia, María Belén, Cozzano Ferreira, Sonia, Arcia, Patricia, Castillo, M. Dolores del
Tipo de recurso: otro
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/423832
Acceso en línea:http://hdl.handle.net/10261/423832
Access Level:acceso abierto
Palabra clave:Amino acids
Anti-inflammatory
Antioxidant
Bioaccessibility
Brewers’ spent grain
Bioactive compounds
Diabetes
Extrusion
Glucose transporters
Short-chain fatty acids
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spelling In Vitro Digestibility and Bioaccessibility of Nutrients and Non-Nutrients Composing Extruded Brewers’ Spent GrainGutiérrez-Barrutia, María BelénCozzano Ferreira, SoniaArcia, PatriciaCastillo, M. Dolores delAmino acidsAnti-inflammatoryAntioxidantBioaccessibilityBrewers’ spent grainBioactive compoundsDiabetesExtrusionGlucose transportersShort-chain fatty acidsThis is a reprint of the Special Issue, published open access by the journal Nutrients (ISSN 2072-6643), freely accessible at: https://www.mdpi.com/journal/nutrients/special issues/bioactive oxidative.This study aimed to evaluate the effect of the extrusion process on the bioaccessibility of brewers’ spent grain (BSG) nutrients (carbohydrates and proteins) and non-nutrients (bioactive compounds). BSG and extruded BSG (EBSG) were digested in vitro simulating human oral-gastrointestinal digestion and colonic fermentation. The duodenal bioaccessibility of glucose, amino acids and phenolic compounds was analyzed. The fermentability of the dietary fiber was assessed by analysis of short-chain fatty acids. Additionally, assessment of the bioaccessibility of phenolic compounds after colonic fermentation was undertaken. The antioxidant, anti-inflammatory and antidiabetic properties of the bioaccessible compounds were studied. Extrusion caused no change in the digestibility of gluten and glucose bioaccessibility (p > 0.05). Moreover, the bioaccessibility of amino acids and phenolic compounds significantly increased (p < 0.05) due to extrusion. However, higher short-chain fatty acid content was formed in colonic fermentation of BSG (p < 0.05) compared to EBSG. The latter inhibited intracellular ROS formation in IEC-6 cells and showed anti-inflammatory properties in RAW264.7 cells. With respect to antidiabetic properties, glucose absorption was lower, and the inhibition of carbohydrases higher (p < 0.05), in the presence of EBSG compared to BSG. The effects of EBSG and BSG digests on glucose transporters were not significantly different (p > 0.05). In conclusion, extrusion positively affected the nutritional value and health-promoting properties of BSG.This research was funded by Agencia Nacional de Investigación e Innovación from Uruguay (POS_EXT_2018_1_154447) and by Ministerio de Ciencia e Innovación of Spain (PID2019-111510RB-I00).Peer reviewedMultidisciplinary Digital Publishing InstituteAgencia Estatal de Investigación (España)Ministerio de Ciencia, Innovación y Universidades (España)Agencia Nacional de Investigación e Innovación (Uruguay)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202620262025info:eu-repo/semantics/otherhttp://purl.org/coar/resource_type/c_3248Publisher's versioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bookPartapplication/pdfhttp://hdl.handle.net/10261/423832reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-111510Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/4238322026-05-22T06:33:51Z
dc.title.none.fl_str_mv In Vitro Digestibility and Bioaccessibility of Nutrients and Non-Nutrients Composing Extruded Brewers’ Spent Grain
title In Vitro Digestibility and Bioaccessibility of Nutrients and Non-Nutrients Composing Extruded Brewers’ Spent Grain
spellingShingle In Vitro Digestibility and Bioaccessibility of Nutrients and Non-Nutrients Composing Extruded Brewers’ Spent Grain
Gutiérrez-Barrutia, María Belén
Amino acids
Anti-inflammatory
Antioxidant
Bioaccessibility
Brewers’ spent grain
Bioactive compounds
Diabetes
Extrusion
Glucose transporters
Short-chain fatty acids
title_short In Vitro Digestibility and Bioaccessibility of Nutrients and Non-Nutrients Composing Extruded Brewers’ Spent Grain
title_full In Vitro Digestibility and Bioaccessibility of Nutrients and Non-Nutrients Composing Extruded Brewers’ Spent Grain
title_fullStr In Vitro Digestibility and Bioaccessibility of Nutrients and Non-Nutrients Composing Extruded Brewers’ Spent Grain
title_full_unstemmed In Vitro Digestibility and Bioaccessibility of Nutrients and Non-Nutrients Composing Extruded Brewers’ Spent Grain
title_sort In Vitro Digestibility and Bioaccessibility of Nutrients and Non-Nutrients Composing Extruded Brewers’ Spent Grain
dc.creator.none.fl_str_mv Gutiérrez-Barrutia, María Belén
Cozzano Ferreira, Sonia
Arcia, Patricia
Castillo, M. Dolores del
author Gutiérrez-Barrutia, María Belén
author_facet Gutiérrez-Barrutia, María Belén
Cozzano Ferreira, Sonia
Arcia, Patricia
Castillo, M. Dolores del
author_role author
author2 Cozzano Ferreira, Sonia
Arcia, Patricia
Castillo, M. Dolores del
author2_role author
author
author
dc.contributor.none.fl_str_mv Agencia Estatal de Investigación (España)
Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Nacional de Investigación e Innovación (Uruguay)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Amino acids
Anti-inflammatory
Antioxidant
Bioaccessibility
Brewers’ spent grain
Bioactive compounds
Diabetes
Extrusion
Glucose transporters
Short-chain fatty acids
topic Amino acids
Anti-inflammatory
Antioxidant
Bioaccessibility
Brewers’ spent grain
Bioactive compounds
Diabetes
Extrusion
Glucose transporters
Short-chain fatty acids
description This is a reprint of the Special Issue, published open access by the journal Nutrients (ISSN 2072-6643), freely accessible at: https://www.mdpi.com/journal/nutrients/special issues/bioactive oxidative.
publishDate 2025
dc.date.none.fl_str_mv 2025
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/other
http://purl.org/coar/resource_type/c_3248
Publisher's version
info:eu-repo/semantics/publishedVersion
dc.type.openaire.fl_str_mv info:eu-repo/semantics/bookPart
format other
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/423832
url http://hdl.handle.net/10261/423832
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-111510
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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