A translational systems biology approach in both animals and humans identifies a functionally related module of accumbal genes involved in the regulation of reward processing and binge drinking in males

Stacey, David; Lourdusamy, Anbarasu; Ruggeri, Barbara; Maroteaux, Matthieu; Jia, Tianye; Cattrell, Anna; Nymberg, Charlotte; Banaschewski, Tobias; Bhattacharyya, Sohinee; Band, Hamid; Barker, Gareth; Bokde, Arun; Büchel, Christian; Carvalho, Fabiana; Conrod, Patricia; Desrivières, Sylvane; Easton, Alanna C.; Fauth-Buehler, Mira; Fernández Medarde, Alberto; Flor, Herta; Frouin, Vincent; Gallinat, Jurgen; Garavanh, Hugh; Heinz, Andreas; Ittermann, Bernd; Lathrop, Mark; Lawrence, Claire; Loth, Eva; Mann, Karl; Martinot, Jean-Luc; Nees, Frauke; Paus, Tomas; Pausova, Zdenka; Rietschel, Marcella; Rotter, Andrea; Santos de Dios, Eugenio Miguel; Smolka, Michael; Sommer, Wolfgang; Mameli, Manuel; Spanagel, Rainer; Girault, Jean-Antoine; Mueller, Christian; Schumann, Gunter

A translational systems biology approach in both animals and humans identifies a functionally related module of accumbal genes involved in the regulation of reward processing and binge drinking in males

[ES]Nuestros hallazgos indican que el módulo accumbal M5, inicialmente identificado como desregulado en ratones macho Rasgrf2–/–, también es relevante para los fenotipos humanos relacionados con el alcohol, potencialmente a través de la modulación de los mecanismos de refuerzo en el NAcc. Por lo tan...

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Autores:	Stacey, David, Lourdusamy, Anbarasu, Ruggeri, Barbara, Maroteaux, Matthieu, Jia, Tianye, Cattrell, Anna, Nymberg, Charlotte, Banaschewski, Tobias, Bhattacharyya, Sohinee, Band, Hamid, Barker, Gareth, Bokde, Arun, Büchel, Christian, Carvalho, Fabiana, Conrod, Patricia, Desrivières, Sylvane, Easton, Alanna C., Fauth-Buehler, Mira, Fernández Medarde, Alberto, Flor, Herta, Frouin, Vincent, Gallinat, Jurgen, Garavanh, Hugh, Heinz, Andreas, Ittermann, Bernd, Lathrop, Mark, Lawrence, Claire, Loth, Eva, Mann, Karl, Martinot, Jean-Luc, Nees, Frauke, Paus, Tomas, Pausova, Zdenka, Rietschel, Marcella, Rotter, Andrea, Santos de Dios, Eugenio Miguel, Smolka, Michael, Sommer, Wolfgang, Mameli, Manuel, Spanagel, Rainer, Girault, Jean-Antoine, Mueller, Christian, Schumann, Gunter
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2016
País:	España
Institución:	Universidad de Salamanca (USAL)
Repositorio:	GREDOS. Repositorio Institucional de la Universidad de Salamanca
OAI Identifier:	oai:gredos.usal.es:10366/156471
Acceso en línea:	http://hdl.handle.net/10366/156471
Access Level:	acceso abierto
Palabra clave:	Rasgrf2 Mesolimbic dopamine system Dopaminergic neurons Binge drinking Alcoholism alcoholismo

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network_acronym_str	ES
network_name_str	España
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spelling	A translational systems biology approach in both animals and humans identifies a functionally related module of accumbal genes involved in the regulation of reward processing and binge drinking in malesStacey, DavidLourdusamy, AnbarasuRuggeri, BarbaraMaroteaux, MatthieuJia, TianyeCattrell, AnnaNymberg, CharlotteBanaschewski, TobiasBhattacharyya, SohineeBand, HamidBarker, GarethBokde, ArunBüchel, ChristianCarvalho, FabianaConrod, PatriciaDesrivières, SylvaneEaston, Alanna C.Fauth-Buehler, MiraFernández Medarde, AlbertoFlor, HertaFrouin, VincentGallinat, JurgenGaravanh, HughHeinz, AndreasIttermann, BerndLathrop, MarkLawrence, ClaireLoth, EvaMann, KarlMartinot, Jean-LucNees, FraukePaus, TomasPausova, ZdenkaRietschel, MarcellaRotter, AndreaSantos de Dios, Eugenio MiguelSmolka, MichaelSommer, WolfgangMameli, ManuelSpanagel, RainerGirault, Jean-AntoineMueller, ChristianSchumann, GunterRasgrf2Mesolimbic dopamine systemDopaminergic neuronsBinge drinkingAlcoholismalcoholismo[ES]Nuestros hallazgos indican que el módulo accumbal M5, inicialmente identificado como desregulado en ratones macho Rasgrf2–/–, también es relevante para los fenotipos humanos relacionados con el alcohol, potencialmente a través de la modulación de los mecanismos de refuerzo en el NAcc. Por lo tanto, proponemos que los genes que comprenden este módulo representan candidatos importantes para una mayor aclaración en el contexto de los fenotipos relacionados con el alcohol.MINECO PS09/01979 y RD06/0020/0000Canadian Medical Association202420242016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10366/156471reponame:GREDOS. Repositorio Institucional de la Universidad de Salamancainstname:Universidad de Salamanca (USAL)InglésPS09/01979info:eu-repo/semantics/openAccessoai:gredos.usal.es:10366/1564712026-06-07T06:28:51Z
dc.title.none.fl_str_mv	A translational systems biology approach in both animals and humans identifies a functionally related module of accumbal genes involved in the regulation of reward processing and binge drinking in males
title	A translational systems biology approach in both animals and humans identifies a functionally related module of accumbal genes involved in the regulation of reward processing and binge drinking in males
spellingShingle	A translational systems biology approach in both animals and humans identifies a functionally related module of accumbal genes involved in the regulation of reward processing and binge drinking in males Stacey, David Rasgrf2 Mesolimbic dopamine system Dopaminergic neurons Binge drinking Alcoholism alcoholismo
title_short	A translational systems biology approach in both animals and humans identifies a functionally related module of accumbal genes involved in the regulation of reward processing and binge drinking in males
title_full	A translational systems biology approach in both animals and humans identifies a functionally related module of accumbal genes involved in the regulation of reward processing and binge drinking in males
title_fullStr	A translational systems biology approach in both animals and humans identifies a functionally related module of accumbal genes involved in the regulation of reward processing and binge drinking in males
title_full_unstemmed	A translational systems biology approach in both animals and humans identifies a functionally related module of accumbal genes involved in the regulation of reward processing and binge drinking in males
title_sort	A translational systems biology approach in both animals and humans identifies a functionally related module of accumbal genes involved in the regulation of reward processing and binge drinking in males
dc.creator.none.fl_str_mv	Stacey, David Lourdusamy, Anbarasu Ruggeri, Barbara Maroteaux, Matthieu Jia, Tianye Cattrell, Anna Nymberg, Charlotte Banaschewski, Tobias Bhattacharyya, Sohinee Band, Hamid Barker, Gareth Bokde, Arun Büchel, Christian Carvalho, Fabiana Conrod, Patricia Desrivières, Sylvane Easton, Alanna C. Fauth-Buehler, Mira Fernández Medarde, Alberto Flor, Herta Frouin, Vincent Gallinat, Jurgen Garavanh, Hugh Heinz, Andreas Ittermann, Bernd Lathrop, Mark Lawrence, Claire Loth, Eva Mann, Karl Martinot, Jean-Luc Nees, Frauke Paus, Tomas Pausova, Zdenka Rietschel, Marcella Rotter, Andrea Santos de Dios, Eugenio Miguel Smolka, Michael Sommer, Wolfgang Mameli, Manuel Spanagel, Rainer Girault, Jean-Antoine Mueller, Christian Schumann, Gunter
author	Stacey, David
author_facet	Stacey, David Lourdusamy, Anbarasu Ruggeri, Barbara Maroteaux, Matthieu Jia, Tianye Cattrell, Anna Nymberg, Charlotte Banaschewski, Tobias Bhattacharyya, Sohinee Band, Hamid Barker, Gareth Bokde, Arun Büchel, Christian Carvalho, Fabiana Conrod, Patricia Desrivières, Sylvane Easton, Alanna C. Fauth-Buehler, Mira Fernández Medarde, Alberto Flor, Herta Frouin, Vincent Gallinat, Jurgen Garavanh, Hugh Heinz, Andreas Ittermann, Bernd Lathrop, Mark Lawrence, Claire Loth, Eva Mann, Karl Martinot, Jean-Luc Nees, Frauke Paus, Tomas Pausova, Zdenka Rietschel, Marcella Rotter, Andrea Santos de Dios, Eugenio Miguel Smolka, Michael Sommer, Wolfgang Mameli, Manuel Spanagel, Rainer Girault, Jean-Antoine Mueller, Christian Schumann, Gunter
author_role	author
author2	Lourdusamy, Anbarasu Ruggeri, Barbara Maroteaux, Matthieu Jia, Tianye Cattrell, Anna Nymberg, Charlotte Banaschewski, Tobias Bhattacharyya, Sohinee Band, Hamid Barker, Gareth Bokde, Arun Büchel, Christian Carvalho, Fabiana Conrod, Patricia Desrivières, Sylvane Easton, Alanna C. Fauth-Buehler, Mira Fernández Medarde, Alberto Flor, Herta Frouin, Vincent Gallinat, Jurgen Garavanh, Hugh Heinz, Andreas Ittermann, Bernd Lathrop, Mark Lawrence, Claire Loth, Eva Mann, Karl Martinot, Jean-Luc Nees, Frauke Paus, Tomas Pausova, Zdenka Rietschel, Marcella Rotter, Andrea Santos de Dios, Eugenio Miguel Smolka, Michael Sommer, Wolfgang Mameli, Manuel Spanagel, Rainer Girault, Jean-Antoine Mueller, Christian Schumann, Gunter
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Rasgrf2 Mesolimbic dopamine system Dopaminergic neurons Binge drinking Alcoholism alcoholismo
topic	Rasgrf2 Mesolimbic dopamine system Dopaminergic neurons Binge drinking Alcoholism alcoholismo
description	[ES]Nuestros hallazgos indican que el módulo accumbal M5, inicialmente identificado como desregulado en ratones macho Rasgrf2–/–, también es relevante para los fenotipos humanos relacionados con el alcohol, potencialmente a través de la modulación de los mecanismos de refuerzo en el NAcc. Por lo tanto, proponemos que los genes que comprenden este módulo representan candidatos importantes para una mayor aclaración en el contexto de los fenotipos relacionados con el alcohol.
publishDate	2016
dc.date.none.fl_str_mv	2016 2024 2024
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	http://hdl.handle.net/10366/156471
url	http://hdl.handle.net/10366/156471
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	PS09/01979
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Canadian Medical Association
publisher.none.fl_str_mv	Canadian Medical Association
dc.source.none.fl_str_mv	reponame:GREDOS. Repositorio Institucional de la Universidad de Salamanca instname:Universidad de Salamanca (USAL)
instname_str	Universidad de Salamanca (USAL)
reponame_str	GREDOS. Repositorio Institucional de la Universidad de Salamanca
collection	GREDOS. Repositorio Institucional de la Universidad de Salamanca
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15.300719

A translational systems biology approach in both animals and humans identifies a functionally related module of accumbal genes involved in the regulation of reward processing and binge drinking in males

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